Extracellular Matrix News

🥼 Science News by @STEMCELLTech can help you stay on top of the latest cell biology research! 💌 Our website and newsletters keep scientists current with the latest peer-reviewed research, as well as industry and policy news. Learn more 👉 //bit.ly/3Xn6mwV

📊 Investigators investigated the translational potential of IL-11–regulated microRNAs as circulating biomarkers of cardiac fibrosis in patients with aortic stenosis. @CircRes | bit.ly/478OfzH

This review combines ECM diagnostics, therapeutic targeting strategies, regenerative approaches, and computational models from a single precision medicine viewpoint. 🔗 bit.ly/4sfVyhv

🧫 Scientists investigated how cell sheet layering and coculture with human bone marrow-derived mesenchymal stromal cells might restore the chondrogenic capacity of high-passage juvenile cartilage-derived chondrocyte sheets. 🔗 bit.ly/3N6nJjR

🔬 Check out this ultrasound-driven strategy that simultaneously induces mitochondrial apoptosis via ROS, overcoming the depth limitations of conventional light-based therapies and presenting a potent approach for TNBC treatment. 🔗 bit.ly/3PovJNE

🧫 Scientists investigated whether the actin-related protein 2/3 complex, a key actin nucleator, is essential for PDAC cells to overcome extracellular matrix stiffness and facilitate migration. @IntJCanc | bit.ly/4bKinDd

🧫 Researchers combined the bioactivity of dECM with the stability of norbornene hyaluronic acid granular hydrogels to create a system that promotes cell adhesion and allows for ECM release. 👉 bit.ly/4uqnzEH

🧪 Researchers successfully created a microfluidic chip that recreates an inflammation event and directly isolates neutrophils from a small volume of whole blood using a 3D extracellular matrix. 👉 rsc.li/4deM4hR

💉 This study supports the hypothesis that mechanical loading is essential for effective cartilage regeneration in tissue-engineered meniscus with Kartogenin and human synovium-derived stem cells. 🔗 bit.ly/4sGy7xO

🧪 Scientists propose an ECM-biomimetic microenvironment-regulating coating, where a polyethylene glycol linker with antifouling effects is used to graft tailored recombinant humanized collagen type I possessing high cell-adhesive activity. @acsnano | bit.ly/4lhA01f

🧫 Using a hyaluronic acid-based hydrogel platform to model normal and fibrotic lung mechanics, scientists examine the roles of Piezo1 and cadherin-11 in interleukin-6-mediated fibroblast activation. 👉 rsc.li/4sv5jIC

💡 Researchers show that ECM1 is an early regulator of kidney remodelling. Global Ecm1 knockout mice develop spontaneous fibrosis and early death, whereas ECM1 levels markedly increase in biofluids during chronic kidney disease. @NatMetabolism | go.nature.com/4uayGRS

🧪 Investigators report gemcitabine-loaded collagenase-conjugated liposomes that enzymatically remodel the collagen-rich ECM while delivering a cytotoxic payload. @acsnano | bit.ly/4bnfFV0

🧪 Scientists highlight an environmentally friendly and scalable biomacromolecule-engineering approach to integrate biopolymer-based polymers with MPN-mediated nano-reinforcement, enabling sustainable and multifunctional wound-management materials. 👉 bit.ly/4rM52kg

💡 Researchers investigated cell adhesion molecule 1 (CADM1) function in connective tissue mast cells using a monoclonal antibody against the extracellular domain of CADM1, termed 3E1. @SciReports | go.nature.com/40DJo5M

💊 Researchers evaluated the effect of a modified version of a soluble FGFR3 decoy receptor that specifically sequesters pro-fibrotic FGFR3 ligands, FGF1, FGF2, and FGF9 as a potential anti-fibrotic drug. @AJRCMB | bit.ly/4tRmF3T

🌱 Scientists investigated the therapeutic potential of Plant-Derived Exosome-like Nanoparticles, particularly those from Poria cocos-Derived Exosome-like Nanoparticles, in treating lymphedema. @JNanobiotech | bit.ly/4asFZwv

🫁 The authors examine how immunological, mechanical, and metabolic regulators influence fibroblast function in fibrosing interstitial lung diseases. @NatRevImmunol | go.nature.com/4aXJ6vE

🥼 PCOS is characterized by hyperandrogenism and, here, researchers from @imperialcollege investigate the impact of androgens on fibrosis, cell-ECM interactions, and mechanosensing. @SciReports | go.nature.com/4tQI64U

This recent study demonstrates that Poria cocos-derived exosome-like nanoparticles represent a novel and effective nanotherapeutic strategy for lymphedema by orchestrating metabolic reprogramming and inhibiting #fibrosis. 👉 bit.ly/4asFZwv

Researchers identified a Piezo1/YAP1/GLS1 axis linking mechanical stress to metabolic reprogramming and #fibroblast activation in bladder outlet obstruction. ✅ Check out the study: bit.ly/3MB5MJW