Bode Group

@matthias_muhar @jakobfarnung @RaHofmann Thanks to amazing collaborators in the Schulman, @MartinJinek , and Jessberger labs. And most of all to Jeff Bode's lab, who has been with this every step of the way. @RapeLab wrote a News and Views that explains our work far better than I ever could. nature.com/articles/d4158…

Very excited to highlight @jcornlab's beautiful work on the E3 ligase SCF-FBXO31, which recognizes chemically damaged proteins. Mutations in FBXO31 cause disease by substrate-rewiring, really cool. Congratulations to all authors! rdcu.be/d7WGc

It's been a lot of fun to learn so much about machine learning from our fellow students and colleagues in @ETH_DCHAB . Thanks to @jlngtz and @CoperetGroup for getting this started, already more than 2 years ago!

Job Offer: two open positions @ETH_DCHAB Starting date: immediately or upon mutual agreement More info: ethz.ch/en/the-eth-zur… #scs #ETH #job #organic #analytical #chemistry #professor #Switzerland

Chemical Synthesis of Secretoglobin 3A2 Covalent Homodimer and Photocaged Monomeric Variants (Jeffrey W. Bode and co-workers) @bode_lab onlinelibrary.wiley.com/doi/10.1002/an…

Predicting Three-Component Reaction Outcomes from 40k Miniaturized Reactant Combinations | ChemRxiv - go.shr.lc/3WF8Eb4

Sure glad all *we* did was make 40,000 molecules. The project below sounds like much less fun! Researcher steps on deadly vipers 40,000 times to better predict snakebites | Science | AAAS science.org/content/articl…

10/10 See all of this (and more!) in our preprint @ChemRxiv #MachineLearning #Automation #chemistry Predicting Three-Component Reaction Outcomes from 40k Miniaturized Reactant Combinations | ChemRxiv - go.shr.lc/3WF8Eb4

9/10 Taken together, these results show 1) it’s possible to do 50,000 reactions during a PhD and 2) large (but not unreasonably large) training set sizes are highly beneficial for reaction prediction.

Would you like a data set of 40,000 reactions for evaluating your reactivity prediction models? We made it, so you don’t have to. 1/10

After too many delays, we are delighted to be hosting the 9th Chemical Protein Synthesis meeting in Nagoya, Japan from 2-5 June 2024! Join us there for amazing advances in the synthesis of proteins! #protein #peptides ninthcpsnagoya.ethz.ch

@YamauchiLab @ETH_DCHAB @FMIscience See also this outstanding related work on Ub chain synthesis using a photo protecting group by the Okamoto group at @UTokyo_News_en published recently in @J_A_C_S. pubs.acs.org/doi/10.1021/ja…

This works comes from a fantastic collaboration with @YamauchiLab at @ETH_DCHAB and Patrick Matthias at @FMIscience on understanding the role of branched Ub chains in viral infections. For this we need homogenous Ub chains to reconstitute the machinery that uncoats viral capsids.

Need small, polar protecting groups that can be orthogonally removed from folded proteins? Our Ub chain team came up with two, and used them to chemoenzymatically assemble branched and heterotypic Ub chains. Just published in @ACSCentSci! pubs.acs.org/doi/10.1021/ac…