Marcelo Freire #drInflammation

Hundreds of scans hint at how substances such as psilocybin, LSD and ayahuasca alter connections between key areas of the brain go.nature.com/4tzwLVX

Huge congrats to Claire Houcheon receiving the 2026 IADR STAR Fellowship! 🏆We will host her in my laboratory @JCVI to dive into #SpatialTranscriptomics . It’s an honor to support the next generation🫶 🧬@IADR #IADR #DentalResearch #JCVI #ScienceMentorship #Research

I've been sick with ME/CFS & related comorbidities for 20 years and noticed it's really hard to find any reliable info on treatment beyond pacing recommendations So I built a treatment database for our community, covering ME, LC, POTS, MCAS, FM, SFN thespooniverse.org/treatments

We didn't find this exact pattern in the ileum tissue, indicating that these results are specific to the colon of LC. Spike-positive rna and prn regions also showed in healthy controls but did not show these gene abnormalities in the transcripts of immune pathways seeing in LC.

In colon tissue of #Long Covid subjects, Spike positive regions revealed significant changes in the transcriptome. Similar to tumor signaling and Crohn's disease gene expressions. Overall, chronic inflammation transcripts dominated these spike positive regions in LC samples.

@lxub84387 Needs to happen soon

@drmfreire 估计什么时候能生产出来解药，已经等5年了！

What is persistent #SARS-CoV-2 Spike doing in gut tissue in situ? In our new preprint, we used spatial transcriptomics, RNAscope, GeoMx DSP, and multiplex IF to investigate biopsies from #LongCOVID The immune dysfunction happen on spike + regions of LC. biorxiv.org/content/10.648…

We found that Spike⁺ regions show: • immune cell remodeling • suppressed chemokine signalling • epithelial stress programs In LC tissue, these regions display transcriptional signatures resembling tumorigenesis, Crohn’s disease–associated pathways, and #chronic #inflammation

In this collaborative study funded by @polybioRF, we have detected gene signatures specific of Long covid tissue regions. Persistent SARS-CoV-2 antigen is not biologically inert in tissue, in fact super active with both immune suppression and activation. @PutrinoLab @AmyProal

We have sequenced the microbiome of six Brazilian biomes: #Amazon, #AtlanticForest, #Cerrado, #Caatinga, #Pampa, and #Pantanal. This massive effort, led by my colleagues @Embrapa and my lab at @JCVenterInst had the goal to develop a deeper understanding of the foundation of our ecosystems. Our hope? To use this knowledge to help preserve & regenerate ecological systems that are failing. Read the @biorxivpreprint here: 🔻 biorxiv.org/content/10.110…

Summer Internships ✨ This summer at #JCVI, students in #STEM are exploring science in the areas of human biology, infectious diseases, oceanography and synthetic biology. My laboratory has 7 interns and the projects range from #inflammation, #LongCovid, #tissuepathogenesis. We are lively lab that is not going to back down from what the government is doing. This is only possible due to funding from @prebysfound and @polybioRF empowering the opportunities of these young scientists and the experiments they are doing! #JCVI #UCSD #FutureScientists

🦠 #Biofilms in the Mouth impacting the whole body? In our lab, we focus on oral pathogens with systemic implications, specially inducing chronic #inflammation. One such microbe is Aggregatibacter actinomycetemcomitans (Aa)—a key player in periodontal disease and, as our work showed, a significant colonizer of biomaterials like #titanium implants. 🔍 In our earlier study (pmc.ncbi.nlm.nih.gov/articles/PMC34…), we developed a model demonstrating Aa's strong preference for rough titanium oxide surfaces. Building on that, we designed a therapeutic approach to control Aa locally and systemically (pmc.ncbi.nlm.nih.gov/articles/PMC50…). Biofilms can lead to microbial migration into blood vessels which can impact other tissues. Better therapeutics need to focus on tissue pathogenesis with biofilm derived microbes.

Check out this new paper by @microbeminded2 @MichaelPelusoMD and colleagues describing new insights and clinical trial recommendations for "Targeting the SARS-CoV-2 reservoir in long COVID" 👇 @polybioRF sciencedirect.com/science/articl…

Over 800 million adults are now living with diabetes worldwide with more than half not receiving treatment, global analysis suggests. On #WorldDiabetesDay, explore the data: hubs.li/Q02Yb3Fg0

Here's our statement on the results of the 2024 presidential election:

GLP-1 receptor agonists, which are effective for weight loss, can cause substantial muscle loss. A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.li/Q02WgC490

Get ready for our Fall 2024 Symposium—it’s less than a week away! It’s an excellent opportunity to learn about innovative studies our scientists are doing on #LongCovid #MECFS and #Lyme+. polybio.org/fall-2024-symp…

🎃Happy Halloween 🎃 From #JackSparrow. To me #Halloween is a day of fun, fantasy and creativity. Much love from the Pirates of the Caribbean 🏴‍☠️🎈🖤

@ImmunologyAAI @VirusesImmunity My favorite association ✨I remember the first day I went to the basic immunology course. And now I have a mucosal immunology lab 🧫

Travel award applications for IMMUNOLOGY2025™️ now open! Don’t miss this opportunity to boost your professional development. Apply by November 19 at ow.ly/eZL050TLE7A. #AAI2025 #IMMUNOLOGY2025

A discovery of a bacterial derived enzyme that could change the face of many autoimmune diseases that involve IgG auto-antibodies cell.com/cell/fulltext/… @CellCellPress @EmoryUniversity @RockefellerUniv