Amy Proal, PhD

It was great to do this podcast. Persistent #viruses - and many bacteria, fungi and even parasite pathogens - directly hijack our #mitochondria. They can hack and distort human gene signaling that controls senescence & inflammaging. This knowledge is huge for longevity treatments

@femalelongevity It’s great if you are testing for persistent infection several times a year as part of optimizing your fitness. I’d love to come on your podcast to discuss! Thanks for DMing me about it

@microbeminded2 Agreed, I talk often about this as I test for them multiple times per year, want to come on my podcast and talk about it?

It's madness that most people in the healthspan-extension space do little to control the activity of #viral, bacterial, #parasite and other pathogens that can hack their bodies over time. Come listen to me talk at the Liberty Hotel next Thurs where I will discuss how to change this by optimizing anti-pathogen treatment approaches! eventbrite.com/e/health-innov…

@_bjv__ We are funding a $1M ME/CFS program at UCSF that includes a large gut tissue analysis project designed to determine if we can replicate John Chia’s findings. We even worked with John on the design of the program: polybio.org/1m-polybio-don…

@microbeminded2 Wasnt that the same idea in Dr Chia studies on enteroviruses that no one decided to follow up. Coxsacke and Echovirus persisting in gut and CNS tissue at low levels causing immune dysregulation But instead we get Ldn studies

Check out these talk summaries from our recent PolyBio Symposium👇 Highlights include that four groups — Tim Henrich (UCSF), Marcus Buggert (Karolinska), Nicolas Huot (Institut Pasteur), and Esen Sefik (Yale) — presented different lines of evidence (human gut biopsies, non-human primate models, humanized mice) all pointing to the same conclusion: SARS-CoV-2 persists in #LongCovid gut tissue and adjacent lymphoid structures, and that persistence drives ongoing immune dysregulation.

7/ Additional work is investigating whether SARS-CoV-2 persists within vascular tissue itself, potentially sustaining chronic inflammation and cardiovascular risk.

6/ Researchers reported increased fibrin-amyloid microclots, elevated neutrophil activation and NET formation, platelet-monocyte aggregates, altered platelet serotonin, SARS-CoV-2 RNA detected in platelets, and evidence that Spike immune complexes can directly drive vascular injury.

@brailemom @polybioRF We will also be posting written summaries soon

@polybioRF Other than the tweets on it is there a written summary?

We’re happy to share that PolyBio’s Spring 2026 symposium that took place last Friday is now available in a recording! Listen to PolyBio-supported project updates at your own pace, or share your favourite research with friends. Presentations by researcher: polybio.org/spring-2026-sy… Full recording: youtu.be/tD5gWVEjudQ?si…

Hey! If you’re in Boston check out my talk this Tues at @LongevityGL Aging Code Summit I’ll overview mechanisms by which persistent infections can accelerate human aging processes. This includes how viruses, parasites & other pathogens directly hijack our mitochondrial activity

Follow along with the #polybiospringsymposium2026 in this thread👇🏻 11:00 am ET—Dr. Amy Proal kicked off this Spring symposium with an overview of PolyBio’s new commercialization network that will help translate Long COVID biomarkers from the lab & therapies from coordinated clinical trials into useful tools in the clinic. She also discussed how this commercialization infrastructure can be applied to other IACIs.

Yes I am excited! Some of the updates on our Long COVID and related chronic illness projects will be truly interesting. See you tomorrow! PS: There is a Q&A at the end of each hour so get your questions ready

So let's go! We've put out a lot of papers and changed the field, but people are still sick. Let's get all of these scientific advances out of academic labs and into patients' lives.

12/ This is the systems-level approach that transformed HIV from fatal to manageable - and it's now being built for Long COVID

This is an incredible $10M donation to our PolyBio Long COVID Cure Initiative (LCCI) Program. Funds are from the Park-Pagliuca Fund: a philanthropic collaboration between the families of Todd Park & Steve Pagliuca, each of whom have family members impacted by Long COVID