Chappell Lab

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Chappell Lab

Chappell Lab

@ChappellLab

RNA synthetic biology lab, Rice University

Inscrit le Aralık 2020
655 Abonnements877 Abonnés
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Chappell Lab
Chappell Lab@ChappellLab·
New paper out! Introducing SynORI: synthetic, modular origins of replication engineered from one origin to enable tunable copy number and compatibility. We co-transform 6 SynORI at once, build signal-driven copy control for multiplexed reporting, and more! nature.com/articles/s4146…
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Chappell Lab
Chappell Lab@ChappellLab·
Honored to have RNA-addressable modification(RAM) featured on the front cover of Nature Biotech. RAM is a new reporter to measure DNA uptake in complex microbial communities using a synthetic barcoding ribozyme! Awesome collaborative project with @lauren_stadler and @JoffSilberg
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Lauren Stadler
Lauren Stadler@lauren_stadler·
The Stadler and Chappell labs (@ChappellLab) are hiring a joint postdoc to join an NSF-funded project on isolating and engineering environmental plasmids for microbiome engineering applications! Email jc125@rice.edu and ls58@rice.edu to apply.
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Tom Ellis
Tom Ellis@ProfTomEllis·
Online now @ Cell is the yeast multicellular engineering paper from @DrFankangMeng - the fruits of his productive PhD. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - adhesion, juxtacrine signalling and more. cell.com/cell/fulltext/…
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Michael Koeris
Michael Koeris@mkoeris·
📢 ALERT ALERT 📢 #BTO's monthly newsletter has dropped! Check it out for the latest and greatest opportunities over here at #BTO! Visit the @DARPA webpage for more info: buff.ly/5piNgIf 🫡
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Ophelia Venturelli
Ophelia Venturelli@oventurelli2·
Excited to share our latest work on unraveling the role of a key metabolic pathway in human gut microbiome assembly and health-relevant metabolites—powered by machine learning! Led by the talented Yiyi Liu sciencedirect.com/science/articl…
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Aditya Kunjapur
Aditya Kunjapur@kunjapur·
It seems there are no free-living organisms known to rely exclusively on one other organism for their survival. Until perhaps now. Check out our latest publication in @NatureMicrobiol to see how we designed an exclusive microbial reliance using GCE. rdcu.be/ekepI 1/2
Aditya Kunjapur@kunjapur

Genetic code expansion - meet synthetic ecology We designed an exclusive reliance of one engineered bacterial strain on another mediated by a non-standard AA Exclusive reliances btwn free-living organisms aren't known in nature Work led by NSF GRFP recipient Mandy Forti

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Romero lab
Romero lab@romerolab1·
Happy Sunday to all! This morning, we are excited to share Chase’s work developing a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! (Small 🧵 below)
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August Staubus
August Staubus@AOStaubus·
Happy to announce the our paper describing a new tool for tracking horizontal gene transfer using a splicing ribozyme has been published in Nature Biotechnology! Thanks to everyone on the team for their hard work nature.com/articles/s4158…
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Lauren Stadler
Lauren Stadler@lauren_stadler·
Fresh in @NatureBiotech! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with @ChappellLab & @JoffSilberg and incredible students. nature.com/articles/s4158…
Lauren Stadler@lauren_stadler

Thrilled to share our new preprint on using a new type of microbial memory to track horizontal gene transfer in environmental microbial communities. Amazing collaboration with @ChappellLab and @JoffSilberg labs. biorxiv.org/content/10.110… (1/n)

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Chappell Lab
Chappell Lab@ChappellLab·
Pre-print alert: Introducing SynORI: Synthetic origins of replication for customizable and controllable plasmids! Lots of cool applications like co-maintaining six orthogonal plasmids in E. coli for a week and copy-control biosensors! biorxiv.org/content/10.110…
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@lauren_stadler @JoffSilberg @DrFankangMeng @DARPA @kunjapur @NatureMicrobiol @LucksLab @NUSynBio