Francesca Khani, MD

577 posts

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Francesca Khani, MD

Francesca Khani, MD

@FKhaniPath

Associate Professor of Pathology, Weill Cornell Medicine. Specializing in Urologic pathology. #gupath Opinions/views are my own.

New York, NY Inscrit le Mart 2014
582 Abonnements1.6K Abonnés
Francesca Khani, MD
Francesca Khani, MD@FKhaniPath·
@HimanshuNagarMD @seanmmcbride @rovingatuscap Simple question- difficult answer! Definition of “cribriform” and thresholds for mentioning it in pathology reports are quite variable among pathologists, (including among GU experts,) and between institutions.
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Sean McBride
Sean McBride@seanmmcbride·
Very compelling data: cribiform pos vs not to help triage men who are otherwise considering AS. Nice to see! How about a C-index head-to-head for MFS prognostic models? CAPRA + DECIPHER v CAPRA + Cribiform vs CAPRA + DECIPHER + Cribiform (or insert your next gen biomarker du jure). Obviously they're collinear, but does DECIPHER (or ARTERA) capture additional prognostic data above and beyond the presence or absence of cribiform pattern? These data already out there? #pcsm #radonc
Nikita Sushentsev@NikiSushentsev

1/2 Just published in @JAMAOnc: 15-year outcomes of Active Monitoring, Surgery, and Radiotherapy for cribriform-positive and cribriform-negative prostate cancer in the ProtecT trial. Secondary analysis based on centralised biopsy review🔬 Article: jamanetwork.com/journals/jamao…

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Francesca Khani, MD retweeté
American Academy of Pediatrics
American Academy of Pediatrics@AmerAcadPeds·
Pediatricians do not profit off vaccines. In fact, most pediatricians either break even or even lose money when they offer vaccines. Misleading parents about doctors' motivations puts children's health at risk and sows distrust in lifesaving vaccinations. nyti.ms/4lwVbM4
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Francesca Khani, MD
Francesca Khani, MD@FKhaniPath·
@SalamonSMD @jjfitzgeraldMD Pathologist here- confirming that no extra stains/markers needed, as endometrial glands and stroma are easily seen on routine H&E preparation. If we see endometrial tissue in a location outside the uterus, it is endometriosis.
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Spela Salamon, MD, Ph.D.
Spela Salamon, MD, Ph.D.@SalamonSMD·
@jjfitzgeraldMD I could look into that for you, but my area of expertise is mainly medical imaging. However, histo diagnosis should not be very problematic provided a representative biopsy sample. Endometrial tissue has a very characteristic look under the microscope.
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Jocelyn J. Fitzgerald MD
Jocelyn J. Fitzgerald MD@jjfitzgeraldMD·
Hello! Severe menstrual pain is endometriosis until absolutely proven otherwise by an expert surgeon. Never normalize this.
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Ashley Winter MD || Urologist
Ashley Winter MD || Urologist@AshleyGWinter·
My kid loves daycare she runs right in in the morning and starts playing and literally doesn't look back 🤷‍♀️
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Francesca Khani, MD
Francesca Khani, MD@FKhaniPath·
@clhubes Also with an infant and toddler here, and I tell myself I’m going to do this every night but still haven’t yet. So… I think maybe it’s not possible.
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Francesca Khani, MD
Francesca Khani, MD@FKhaniPath·
@Gleason4plus5 @rovingatuscap I only apply the “significant cytologic atypia” criterion for when the architecture of the intraductal proliferation is micropapillary (as opposed to dense cribriform), and if there isn’t necrosis. Marked cytologic atypia is what would distinguish IDC from micropapillary PIN.
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Matthew Wasco
Matthew Wasco@Gleason4plus5·
@rovingatuscap I have never understood the requirement for "significant cytologic atypia" for calling something IDC. The atypia is almost always the same level of atypia as the invasive neoplasm, it's not going to likely be higher. For calling an isolated focus, maybe then be stricter.
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Samson W. Fine, MD
Samson W. Fine, MD@rovingatuscap·
Takeaways #2 from poll below: - majority would report as Intraductal Carcinoma - 🤔A: historical "cribriform PIN" = AIP/IDC-P in contemporary reporting - 🤔B: though some will also require cytologic atypia, IMO, this degree of dense cribriforming=IDC-P #gupath #ProstateCancer
Samson W. Fine, MD tweet media
Samson W. Fine, MD@rovingatuscap

#PathTwitter #gupath folks - in the following scenario: - intraductal proliferation (basal cell marker #IHC +) - dense cribriform architecture - background HG #prostatecancer (GS459/GrdGrp 5) 2 questions: polls in Tweets/posts below 👇🏻👇🏻👇🏻

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Francesca Khani, MD
Francesca Khani, MD@FKhaniPath·
@anusubram It is outrageous that insurance companies are dragging their feet with this…don’t they realize it would be better to pay the few hundred dollars for a vaccine/monoclonal antibody vs paying multiple thousands of dollars for potential inpatient/ICU admission due to RSV?
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Anu Subramony
Anu Subramony@anusubram·
This is such an example of how doing what is right for children is determined by finance considerations. We will lose if we don't stand up for doing what's best. New RSV protections for infants hit cost, insurance hurdles in U.S. rollout cnb.cx/48SWYoN
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Francesca Khani, MD retweeté
Pashtoon Kasi MD, MS
Pashtoon Kasi MD, MS@pashtoonkasi·
🗞️@Forbes Published today! Are we on the verge of a new drug combo for colorectal cancer? Read more about our work on this immunotherapy called the BOT (Botensilimab). We describe this “inside-out”🌊 wave of regression by immune cells. @TheAlexKnapp forbes.com/sites/alexknap…
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Francesca Khani, MD
Francesca Khani, MD@FKhaniPath·
This was a great team effort with amazing leadership from @mishabeltran and @notSoJunkDNA. And big thanks to all collaborators for their various contributions!
Nicolas Robine@notSoJunkDNA

We (@nygenome cancer compbio group) are very fortunate to work closely with @WCMEnglanderIPM and have several papers in preparation. Here is one focused on brain metastases in prostate cancer with @FKhaniPath @willbfx @mishabeltran nature.com/articles/s4169…

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@HimanshuNagarMD @seanmmcbride @rovingatuscap @HubJHU @SalamonSMD @jjfitzgeraldMD @AshleyGWinter @amac25