COMBINE Lab@UCL

Just in time for AAIC: Our work on investigating the regional spread of amyloid and tau is now available in @Brain1878 With: @NeilOxtoby @WijDr @ilopesalves @LECollij @_JakeVogel_ @FBarkhof @fishpiechicken doi.org/10.1093/brain/…

Join us tomorrow for "The Basics of GWAS in Alzheimer's Disease". Sign up here alz-org.zoom.us/webinar/regist…

4 yr fully-funded PhD* to understand how dementia causes 'brainsight' loss in the largest imaging-genetics study (UK Biobank) & posterior cortical atrophy (visual variant Alzheimer's): tinyurl.com/te9snjdx * @EPSRC * @BrainAppeal @drcionucl @RareDementia @UCLIoN @CombineLab

Latest paper out of the @EDADS_jpnd project led by us at @CMICUCL is about Alzheimer's disease-sensitive harmonisation, improving on Combat and Neuroharmony (which can erase disease signal). doi.org/10.1148/ryai.2… FAO: Quantitative Neuroradiology enthusiasts

@wandedob This is wild!

What is this??? sciencedirect.com/science/articl…

HOW DOES YOUR GENETIC CODE affect your brain? 💡A new genetic roadmap of the brain (in today's Nature Genetics) reports: 💡100s of genomic loci affect deep brain structures 💡Genetic variants driving brain volume overlap with risk loci for Parkinson's, ADHD, many brain diseases ⚡️Studied N=74,898 people scanned with MRI + GWAS ! ⚡️⚡️Polygenic scores now account for up to 10% of the regional brain volume variation in held-out, independent samples not used for discovery; modeling this variance should help future studies 👉👉PDF: nature.com/articles/s4158… 🎈Kudos to Luis García-Marín*, Adrian Campos* + @sudha_md @Frutiloopz @WiroNiessen @jsteinlab @njahanshad @lishenlc @amarquand @mallarchkrvrty1 @StefanEhrlich3 @Roshchupkin @ASaykin @_MariekeKlein_ @AvramHolmes @BFranke_lab @lianne_schmaal @jorsmo @lemaitreh_alien @vdcalhoun + 189 researchers worldwide collaborating for 7 years to do this ! @enigmabrains @chargetiger @uk_biobank ABCD + many more ... 🎈 *co-1st authors

In this week’s podcast episode, Stanford neurologist Michael Greicius discusses the promising future for Alzheimer’s therapies despite skepticism toward the effectiveness of new treatments that target amyloid plaques. #alzheimers #neuroscience 🔗neuroscience.stanford.edu/news/why-new-a…

Come on in and join us ! @KonradWagstyl and I have a fully-funded 4 yr PhD-ship open thru the super NIMH-UCL (D.C/London) graduate program partnership (shorturl.at/Qr5uq). Bridge Macro<-> views of 🧠 wt neuroimaging & omics (e.g. shorturl.at/W2cgo). Pls DM/apply ! 😃

🔥Two Lecturer posts available in our Department 🔥 Interested in leading research that combines engineering/physics/robotics/AI with medicine? This is the place! Closing Date: 4th Oct 2024. DM me if you have any questions.

Disentangling genetic risks for development and progression of Alzheimer’s disease New scientific commentary by Niklas Mattsson-Carlgren tinyurl.com/4p5shuwp

Earlier this month @TheLancet Commission led by Prof @Gill_Livingston (@UCLPsychiatry) found that nearly half of #dementia cases could be prevented or delayed by tackling 14 modifiable health & lifestyle factors through our lives: bit.ly/4fkUwuy

AI’s promise in ophthalmology is immense, from handling patient backlogs to improving care. But success hinges on creating the right ecosystem. Professor @pearsekeane, @UCLeye shares his perspective in @OphthoMag. bit.ly/3yayBWn

The figure we all have to learn by heart: The updated Lancet Commission on potentially modifiable risk factors for dementia. #AAIC24

More than 100 neuroimaging researchers, including @furranko, @demwassermann, @memartone, have signed a statement for the leadership of @uk_biobank —in protest of a switch from a data-download to cloud-only access model. By @callimcflurry bit.ly/4d24501

Estarellas et al. report that an adapted Subtype and Stage Inference algorithm accommodates missing data in multimodal #Alzheimersdisease studies. @mar_estarellas @UCLMIGPOND @NeilOxtoby @jmschott @fishpiechicken @YoungAlexL edin.ac/3SjesUI

So thrilled to see our Imaging-genetics paper finally out in A&D!! And even more that this is happening during an amazing AAIC, were we first presented these results last year. ... 🎈 alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

A few more days left to apply for this PhD opporunity (deadline has been extended to the 21st July)

🚨I'm delighted to share a new publication from the #BettencourtLab team by @megha7murthy et al. on a cross-comparative investigation of #brain #DNAmethylation patterns in #MSA, #PD, #PSP. doi.org/10.1007/s00401…. Thank you to all involved🙏! @UCLIoN @MSAtrust #epigenetics

Delighted to introduce Professor Sir John Hardy as Vice President of ⁦@AlzResearchUK⁩ John is a shining light in our field & long time supporter. Do join me in welcoming him by reading my blog #ForACure alzheimersresearchuk.org/news/introduci…

UCL Medical Image Computing Summer School 2024

or actually... visual-led dementia not 'demention'. 'Covfefe' anyone?

Fantastic opportunity to work on imaging and genetic data in visual-led demention 👇👇👇