Jason Stein

New preprint from our lab led by an amazing team, @ckvuong and Alexis Weber, were we employ single-cell multi-omics in the developing brain to uncover mechanisms of Down syndrome. #brain #singlecell #multiomics #DownSyndrome biorxiv.org/content/10.110…

Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors @jsteinlab @NanaMatoba @jmvalone4 @BrandonDLe nature.com/articles/s4159…

It’s been a long journey🚢, with about 1 & 1/2 year since posting on bioRxiv and of course even longer since the project started, but our paper has finally been published in @NatureNeuro 🌠 Congrats @BrandonDLe @jmvalone4 @jsteinlab and all co-authors ! nature.com/articles/s4159…

📢New from @jsteinlab! 📰 #Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis cell.com/ajhg/abstract/…

Dr. Jason Stein's lab (@jsteinlab) at @UNC determined the cross-site reproducibility of human cortical #organoid 🧫 (hCO) differentiation using three independent research groups to assay hCOs in multiple differentiation replicates. @stemcellreports | bit.ly/4dDxaiJ

The authors of @AJHGNews' latest article identify cell-type-specific genetic regulation of RNA editing and alternative polyadenylation in human neurons and neural progenitor cells. Read the full article here: cell.com/ajhg/abstract/… #ASHG @jsteinlab

I am beyond excited to share our new paper on massively parallel reporter assays on schizophrenia-associated variants. This is in collaboration with @jsteinlab, @srikosuri, @mikelove, @_josedavila, @brad_ruzicka, @AP_Boyle. 🧵 follows.

We @jsteinlab are delighted to present our recent preprint investigating the impact of genetic variants on cell-type-specific post-transcriptional regulation in human brain biorxiv.org/content/10.110…

Neocortical Neurogenesis in Development and Evolution edited by WIELAND B. HUTTNER is out doi.org/10.1002/978111…. Superb resource to learn about cortical progenitors; lineages; specification; migration; patterning; cortical regionalisation; folding; disorders; evolution.

Excited to share a new preprint on the cross-site reproducibility of human cortical organoids co-led with Elisa Waxman & Deborah French at CHOP and Satoshi Yamashita & Kazue Hashimoto-Torii at Children's National and my PI @jsteinlab! biorxiv.org/content/10.110… 1/9

@njahanshad @JulioVillaln1 @lilOHBM I always wondered what happened to that poster

@JulioVillaln1 @lilOHBM One of those looks suspiciously familiar @jsteinlab

Little OHBM 2023 happening now. Can you find it? #lilOHBM2023 #OHBM2023 @lilOHBM

@mikelove @natstann @hyejung_won @dphansti @cohenlaboratory probably have some ideas

@natstann @jsteinlab @hyejung_won maybe members of Jenny Ting lab?

hi UNC colleagues - I am very interested in microglia and neuroimmunology these days. Will you please comment if you would be interested in a microglia /neuroimmunology focused journal club? :)

Learn how Felix Kyere, Ian Curtin, Jason Stein and colleagues of @UNC perform whole-brain single-cell imaging and analysis of mouse brains using MRI, tissue clearing, and light-sheet microscopy. Watch on JoVE: hubs.ly/Q01S6wjB0 @jsteinlab @FelixKyere @curtin_ian

Our recent work together with @jsteinlab and @mikelove is published in @GenomeBiology, to understand cell-type specific causal gene regulatory networks via mediation analysis. To access the full article please click genomebiology.biomedcentral.com/articles/10.11…

@TheHectorFranco Congrats Associate Professor Franco! Let's party! 🥳

Its official! I have been promoted to Associate Professor with Tenure at UNC. What a journey! I have learned how to be creative when resources were low, persistent when facing challenges, and fearless when setting goals. All the way from a small town in Puerto Rico! 🇵🇷 💪😀

@jameemaemusic That's a pretty cool paper I hear

Light reading 😆🧠🧬@jsteinlab

Super excited to host @BrandonDLe from @jsteinlab next Tuesday at 3pm for the #neurogenomics seminars. Bran will present the lab's excellent recent work linking wnt pathway activation with context specific regulatory QTLs. DM/email for the zoom link

@RRSharp122 @sean_johnsen I hope this helps explain our lab's goals and also clears up any incorrect perceptions. You are welcome to join our lab meetings or journal clubs to come and learn more about what we do and discuss further.

@RRSharp122 @sean_johnsen Enrichment of educational attainment GWAS within regulatory elements active in the brain and developing brain, and colocalization of brain e/caQTLs with educational attainment GWAS