David F. Meaney Lab

@neubadah We’re looking to hire a tech and a post-doc interested in (1) how the brain protects itself against concussion and (2) how we can use exosomes to understand the brain’s injury response & treat concussion. Learn more at seas.upenn.edu/~molneuro/inde…!

Head impacts do more than damage brain tissue – they may disrupt how blood flow and neural activity work together, with consequences that current injury models often miss. Researchers probed this issue by integrating biomechanical and neurodynamic modeling approaches to assess how head impacts alter large-scale brain activity via structural damage and shifts in local tissue oxygenation. Using a network model informed by structural and vascular dynamics, they simulated 53 real-world head impacts and tracked changes in brain activity across different vascular anatomies. The model showed strong discrimination between concussion and non-concussion cases while revealing distinct patterns of network disruption across injury types. It also showed that vascular differences can influence how resilient the brain is to these effects. Understanding how vascular dynamics shape brain response to impact could enable more personalized injury prediction, protection strategies, and recovery pathways. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10.100… 𝗦𝘁𝘂𝗱𝘆: A Proposed Novel Neurovascular Mechanism for Brain Network Dysfunction After Traumatic Injury 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: @taotaowu09, @realmitchberger, @rayfield_a, Keith A. Kroma-Wiley, @DaniSBassett, and @DFMeaneyLab @Penn @PennEngineers @pennbioeng @ESEatPenn @PennMedicine @PennNSG 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10439

🎧 🎤 Our 2nd episode of the Innovation & Impact podcast, "RNA: Past, Present and Future" is now available, featuring @DFMeaneyLab, @MJMitchell_Lab and @noor_M0MIN. Hear how RNA has impacted the health care and biomedical engineering technologies. bit.ly/45cHzwN

Exciting News! Taotao's New Lab Opening! Don't Miss Out!👨‍🔬👩‍🔬 #PhDposition

The Meaney Lab is at @Neurotrauma 2023! Come see Adam’s (@rayfield_a) poster P04.067 today at 5pm on the functional outcomes of targeted in silico and in vivo brain lesions

Thank you to our alumni judges for an amazing Senior Design Expo! Enjoying drinks after an amazing day with the instructors, Sevile, @eerinberr and @DFMeaneyLab. @Penn @PennEngineers #PennEngineering #BioMakerSpace #MakerSpace #Bioengineering #BioMedicalEngineering

Our Fall 2022 Senior Design "Minimum Viable Product" demos! Stop by tomorrow to see their final products! Learn more: belabs.seas.upenn.edu/seniordesign/2… @Penn @PennEngineers #PennEngineering #BioMakerSpace #MakerSpace #Bioengineering #BioMedicalEngineering

We're looking for a Research Associate in Computational Biomechanics! uva.wd1.myworkdayjobs.com/UVAJobs/job/Ch…

#Flashback to BE 3090 - Bioengineering Modeling, Analysis, & Design with David Meaney of @DFMeaneyLab and Michael Patterson! @Penn @PennEngineers #PennEngineering #BioMakerSpace #MakerSpace #Bioengineering #BioMedicalEngineering

Daves discussing. @DavidIssadore @DFMeaneyLab @Penn @PennEngineers #PennEngineering #BioMakerSpace #MakerSpace #Bioengineering #BioMedicalEngineering

Hear what @PennEngineers Senior Associate Dean Dave Meaney of @DFMeaneyLab has to say about our Bio-MakerSpace. @Penn #PennEngineering #BioMakerSpace #MakerSpace #Bioengineering #BioMedicalEngineering

What a treat to show off the @PennBElabs to President Liz Magill. What’s a visit to the BE Labs without a cockroach demo? 🪳 #PennBioengineering

Concussion Prone Scenarios: A Multi-Dimensional Exploration in Impact Directions, Brain Morphology, and Network Architectures Using Computational Models @pennbioeng @uvamae @UVABME @UVAEngineers @DFMeaneyLab @taotaowu09 @BMESociety @SpringerNature Link: rdcu.be/cZsXU

Bioengineering Modeling, Analysis, & Design (#BEMAD) with Dr. David Meaney of @DFMeaneyLab. @Penn @PennEngineers #PennEngineering #BioMakerSpace #MakerSpace #Bioengineering #BioMedicalEngineering

Ready to give a talk at #IMECE 2022 on resource constrained TBI mechanism. If you are also here, please come and join the conversation. Location: A216; Time: 11:30 @rkraftComputes

Engrams, data science, and machine learning - Exciting work in BE 3090 - Bioengineering Modeling, Analysis, & Design (#BEMAD) with @DFMeaneyLab and Michael Patterson. @Penn @PennEngineers #PennEngineering #BioMakerSpace #MakerSpace #Bioengineering #BioMedicalEngineering

Brianna Wronko, BE 2017 and founder & CEO of @groupkdx, speaking to our Senior Design class (with @eerinberr and @DFMeaneyLab). And she brought her baby! @Penn @PennEngineers #PennEngineering #BioMakerSpace #MakerSpace #Bioengineering #BioMedicalEngineering

Exciting new work from postdoc Taotao Wu on features affecting brain injury risk!

twitter.com/realmitchberge… Awesome job, Jared! You are the creative genius this world needs. (tweet definitely not written by Jared)

I'm also continuing @pennbioeng as a lecturer for senior design (with @DFMeaneyLab and Sevile in @PennBElabs) and my beloved Python programming class! I am beyond excited about the science and education I get to be a part of, with incredible students, mentors, collaborators!