Mukta Deobagkar

Check out our new @SciImmunology paper about the role of DOCK8 in the survival and differentiation of B cells activated by low amounts of antigen: doi.org/10.1126/sciimm… A big shoutout to @CornallLab & @BetterKidneys Thank you @MRC_TIDU @HumanGeneticsOx @NDMOxford @CAMS_COI_Ox

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25

Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs dlvr.it/THPSV5

New Garvan research reveals how hepatitis C triggers autoimmunity through B cell mutations – not molecular mimicry as previously thought. Published in @ImmunityCP, this could transform treatment approaches for a range of autoimmune diseases. ow.ly/uY1V50UHikb

The molecular reach of antibodies crucially underpins their viral neutralization capacity nature.com/articles/s4146… @NatureComms @Dushek @annagesine

Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut @NatureMicrobiol @GutBugs2 @MattagenOlmics nature.com/articles/s4156…

Cao, Burrows, @nkg2d1 @theonlylabever et al. show that Tritrichomonas musculis-driven IgA modifies the commensal bacterial microbiota and improves the generation & dissemination of IgA-secreting plasma cells reactive against orally ingested food antigens. hubs.la/Q02Y4GM00

New research from @YaleIBIO reveals that natural antibodies secreted by a subset of #Bcells prevent reactivation of endogenous #retroviruses in mice. @VirusesImmunity @YYexin Read more in Science #Immunology: bit.ly/3Z7Rd2L

Integrin-αV restricts tissue-resident airway B cell responses by reducing persistence of germinal center reactions locally in the lungs, limiting lung-resident IgA+ memory B cells that are cross-reactive to antigenic variants biorxiv.org/content/10.110…

A must read! The renaissance of oral tolerance: merging tradition and new insights | Nature Reviews Immunology nature.com/articles/s4157…

If one believes in #TCR #crossreactivity, read this #1000times or even more. T Cell Receptor Cross-Reactivity between Similar Foreign and Self Pept... sciencedirect.com/science/articl…

A two-shot #vaccine regimen, delivered a week apart in increasing doses, prolongs antigen capture and boosts T cell priming and #Bcell responses in mice. Read more in Science #Immunology: scim.ag/8ni

Monumental paper by Helen C. Su and collaborators, with profound biochemical, immunological, and clinical implications: Germline mutations in a G protein identify signaling cross-talk in T cells | Science science.org/doi/10.1126/sc…

Vaccine delivery in two doses, synchronized to germinal center dynamics and T cell priming, enhances humoral immunity @SciImmunology #Chakraborty #Irvine @sachinbhag science.org/doi/10.1126/sc…

Trained immunity-based vaccines for infections and allergic diseases @jacionline @Palomares_Lab jacionline.org/article/S0091-…

I'm excited to share the final piece of my doctoral research published today wherein we demonstrate that a two-dose priming vaccine regimen amplifies humoral responses by synchronizing delivery with germinal center dynamics science.org/doi/10.1126/sc…

Incredibly excited that our work is now out in @ImmunityCP! Here we reveal the mechanistic principles of antibody (Ab)-mediated B cell response regulation, ultimately highlighting the utility of Abs to enhance both protein- and mRNA-based vaccines cell.com/immunity/fullt…

Mechanistic framework of how antibodies can optimize protective immunity, regulating B cell response participation and duration in a way that can be harnessed for vaccine design @ImmunityCP @isaak_quast cell.com/immunity/fullt…

Changes in transcript isoforms can alter the function of interferon stimulated genes in human B cells @CellGenomics cell.com/cell-genomics/…

Towards a unifying model for B-cell receptor triggering dlvr.it/TD46qq

Preprint alert 🚨 . Another great collaboration with Aysegul Sapmaz and Paul Geurink in Leiden. This time we identified and characterised USP24 as a deISGylating enzyme with roles in IFN-I production and potential use as an antiviral target. #ubiquitomics