Immunity

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Online now: Antigen-restricted Candida albicans Th17 cells link oral-gut immunity and adopt pathogenic features during intestinal inflammation dlvr.it/TTXG09

Online now: MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion dlvr.it/TTWYRh

Online now: Nasal immunity in respiratory viral infection, transmission, and protection dlvr.it/TTWTp8

Online now: Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity dlvr.it/TTWKwp

Online now: CRISPR-mediated precise large fragment insertion in zygotes enables rapid generation of humanized immunoglobulin heavy-chain mice dlvr.it/TTRBdN

Online now: Transcription factor BHLHE40 expression in group 3 innate lymphoid cells and RORγt⁺ antigen-presenting cells coordinates intestinal immunity dlvr.it/TTPKWf

Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience @ImmunityCP cell.com/immunity/fullt… 🇨🇳

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing: @ImmunityCP cell.com/immunity/fullt…

Great work from @asierra93 and the @RiceLaboratory at @RockefellerUniv in our new paper "Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing" in @ImmunityCP doi.org/10.1016/j.immu…, where we saw inter-organ antiviral crosstalk protected against severe encephalitis, caused by a range of neurotropic viruses across Orthoflaviviridae, Togaviridae, and Orthoherpesviridae

Cross-organ immune circuit where viral pattern sensing in skin potently counteracts viral encephalitis during WNV or neurotropic arbovirus infection via systemic type I IFN signaling in brain endothelial cells cell.com/immunity/fullt… @ImmunityCP @RiceLaboratory @RockefellerUniv

Online now: Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience dlvr.it/TTLKL1

Online now: Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing dlvr.it/TTKcV6

Online now: Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors dlvr.it/TTKXVC

Online now: B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection dlvr.it/TTKNkc

A key question in autoimmunity is what keeps some immune cells helpful while others turn destructive. Two new studies reveal that Th17 cells can self-regulate using built-in steroid signaling, but inflammatory cues like IL-23 can shut this system down, pushing them toward disease-driving behavior and steroid resistance. Read more, both published in @ImmunityCP: mgriblog.org/science-insigh… @AnaAndersonlab

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion @ImmunityCP cell.com/immunity/abstr…

Online now: Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion dlvr.it/TTHSK0

Online now: Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling dlvr.it/TTCjBj

Online now: Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition dlvr.it/TTCXCj

Online now: Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection dlvr.it/TTBw0s