ChemBio@Modification

ADCs specifically kill disease cells but are complex molecules with synthetic challenges. Zhang et al conjugate antibodies with two cytotoxic drugs through different functional groups sequentially to produce "dual" payload ADCs for breast cancer treatment go.acs.org/1IH

Happy to share our newly accepted manuscript in @ChemCommun: "Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy" doi.org/10.1039/D2CC02… pubs.rsc.org/en/content/art…

We're delighted to share our most recent work in antibody conjugation, featuring all-in-one disulfide bridging using TetraDVP reagents. Now in @ChemicalScience, check it out! doi.org/10.1039/d2sc02… @ChemCambridge

Nice one

Nice one

Tyrosines are not only useful in #silk crosslinking but in immobilising molecules on preformed silk #biomaterials too. Check out our latest paper led by @FatemehhhKarimi published in @ACS_AMI 👇 @ASBTE1 @MatrixBioANZ @UNSW #BioMedEng @TyreeIHealthE pubs.acs.org/doi/10.1021/ac…

Happy to share our latest review, by @weizhi_yu, on the latest advances in using photoaffinity labeling for probing lipid-protein interactions, in Curr Opin Chem Biol. Many thanks to @TsukijiLab & Neal Devaraj for the invitation! doi.org/10.1016/j.cbpa…

New team paper led by @DustinTKing, SFU's soon to be newest faculty starting on July 18. Big shout out to the entire team on this long haul project. Looking forward to more fun with gases. nature.com/articles/s4158…

We keep on asking, #enzymes keep on giving! we asked an acylase to recognize 3 different amines on insulin and today we can share new strategy for enzymatic functionalization of native proteins #directedevolution #bioconjugation #merckchemistry science.org/doi/10.1126/sc…

Interesting paper by the groups of @Yang_J_lab and Ping Xu in @JProteomeRes. They directly compared five different cleavable biotin tags and 3 different workflows to characterize their performance in residue-specific chemoproteomics. doi.org/10.1021/acs.jp…

Check out this Communication Article by Injae Shin & first authors Hui Li & Chang-Hee Lee 'A thiol-activated fluorogenic probe for detection of a target protein' Linked below ⬇ rsc.li/3sXwjUO

More than 15 years ago we embarked on a project to combine nucleic acid and boronic acid chemistries. This Personal Account describes our contribution to the field ! onlinelibrary.wiley.com/doi/full/10.10… Thank you The Chemical Record for the invitation ! @ChemBioNAC @umontpellier #OpenAccess

Interesting paper by the group of @ChuWangPKU in @J_A_C_S. An aldehyde probe for site-specific quantification of protein lipoylation in human and bacterial proteomes. The probe forms thioacetals with lipoylated proteins after reduction of the disulfide. doi.org/10.1021/jacs.2…

Nice one. Utilisation of formaldehyde and guanidine moiety for modification of Lysine by cyclisation method.

The group's latest work on peptide macrocyclizations, led by PhD student Hayden Bell @HaydenBChem @ARC_CIPPS @ANUChemistry is out today in @OrgBiomolChem! Congrats, Hayden! Check it out here: pubs.rsc.org/en/content/art…

Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides by ⁦@FujimoriLabUCSF⁩ in @ChemicalScience pubs.rsc.org/en/content/art…

Review: Click Bioconjugation: Modifying Proteins Using Click-Like Chemistry (Stump) @LonzaGroup onlinelibrary.wiley.com/doi/10.1002/cb…

Here is a review about Degrader-ADCs written by Peter Dragovich @genentech. This review is an excellent read based on the significant hands-on experience of the author. And he does a superb job in explaining ADC basics to the lay reader @rsc_medchem #TPD pubs.rsc.org/en/content/art…

Degrader-antibody conjugates pubs.rsc.org/en/content/art…

Alkyne-Tagged Raman Probes for Local Environmental Sensing by Hydrogen–Deuterium Exchange @CaltechCCE @Caltech #Raman #Probes #Environment #Sensing #Deuterium #Exchange pubs.acs.org/doi/10.1021/ja…