Gong Chen

66 posts

Gong Chen

Gong Chen

@GongChenLab

C-H bonds, peptides, carbohydrates

Katılım Nisan 2018
749 Takip Edilen1.5K Takipçiler
Gong Chen
Gong Chen@GongChenLab·
We’ve been dreaming of this type of conjugation chemistry for years—and finally, a simple fix to a stubborn problem, all thanks to just a tiny drop of CS₂. Minimalist chemistry is the new gold. ✨
Gong Chen tweet media
Angewandte Chemie@angew_chem

@gongchenlab have been hunting for ways to crosslink two different amines for conjugation: turns out that just a drop of CS₂ in air delivers great results! Read on in their Research Article: • onlinelibrary.wiley.com/doi/10.1002/an…

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Gong Chen
Gong Chen@GongChenLab·
A huge thank you to our amazing guest editors, Masayuki Inoue, Lara Malins @Malins_lab, and Hans Renata @hanzyduzit, for organizing this OL special issue on radical-mediated reactions! Special thanks to Steve Ritter and Matt Saucier for your invaluable support.
J Org Chem/Org Lett@JOC_OL

Special Issue alert! 🚨 This one is truly •radical• pubs.acs.org/page/orlef7/vs… This VSI highlights the state of the art in radical reaction development and the strategic incorporation of radical reactions in the construction and modification of important molecules.

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Gong Chen
Gong Chen@GongChenLab·
HFIP's magic shines again, enabling peptide stapling with alpha-ketoaldehydes through unique imidazolium linkers, outperforming natural “glycation” processes. We proposed HFIP aggregates act as a proton shuttle for efficient deacylative C--C cleavage.
Gong Chen tweet media
Angewandte Chemie@angew_chem

Peptide Stapling by Crosslinking Two Amines with alpha-Ketoaldehydes through Diverse Modified Glyoxal-Lysine Dimer Linkers (Gong Chen and co-workers) @NKU1919 onlinelibrary.wiley.com/doi/10.1002/an…

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Gong Chen
Gong Chen@GongChenLab·
N-glycoside synthesis, a tough nut to crack, is now approachable with our new light/Cu catalysis method, allowing N-glycosidic bond formation under mild conditions with exceptional water tolerance and unique chemoselectivity. Another fruitful collaboration with MJ Koh @MJKoh87.
Nature Synthesis@NatureSynthesis

Now online: Article by @MJKoh87 @GongChenLab and co-workers @NKU1919 @ChemNUS N-glycoside synthesis through combined copper- and photoredox-catalysed N-glycosylation of N-nucleophiles nature.com/articles/s4416… ($)

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Gong Chen
Gong Chen@GongChenLab·
Two simple reagents, HCHO and hexafluoroisopropanol (HFIP), unleash new chemical magic! HCHO effectively “sucks” the alpha C-H bond from common alkyl amines in HFIP solvent, enabling hydride liberation without metals or light. It works for complex systems, too.
Top Science@isciverse

Formaldehyde-Mediated Hydride Liberation of Alkylamines for Intermolecular Reactions in Hexafluoroisopropanol @J_A_C_S #Chemistry #Chemed #Science pubs.acs.org/doi/10.1021/ja…

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Joseph Moran
Joseph Moran@MoranLabChem·
@GongChenLab Great work! Nice to see there are still important new directions with HFIP.
Strasbourg, France 🇫🇷 English
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Gong Chen
Gong Chen@GongChenLab·
@NitscheLab thank you for the very kind support of our meeting, look forward to seeing you again in Brisbane in a couple of months🤝
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Christoph Nitsche
Christoph Nitsche@NitscheLab·
Big thank you to @GongChenLab and team for their hospitality and the opportunity to present a keynote lecture at the CPS 2023 in Tianjin in June.
Christoph Nitsche tweet mediaChristoph Nitsche tweet media
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NgaiLab
NgaiLab@NgaiLab·
The beginning of a new journey! 😬
NgaiLab tweet mediaNgaiLab tweet mediaNgaiLab tweet media
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Gong Chen
Gong Chen@GongChenLab·
I am deeply humbled and honored to be part of the editor team of Organic Letters. I very much look forward to serving the journal and our organic community☺️
J Org Chem/Org Lett@JOC_OL

We are thrilled to announce that Prof. Gong Chen of Nankai University will be joining #OrgLett as an Associate Editor on December 1. Known for his work on metal-catalyzed C-H functionalization and on peptides and oligosaccharides, Gong may soon be handling your manuscript!

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Squire J. Booker
Squire J. Booker@BookerMan_PSU·
@GongChenLab Nice, Gong!! We'll have to set up a meeting to chat about this interesting work!!
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Gong Chen
Gong Chen@GongChenLab·
Our lucky streak continued! Formaldehyde can glue amine and guanidine together like a charm :) Thank Xiaosong Xue at Nankai and SIOC for the computational collaboration! pubs.acs.org/doi/10.1021/ja…
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junwu
junwu@junwu54104779·
@GongChenLab Congrats to profs Chen and your team members, such an impressive peptide stitching strategy!
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