Dimitrios Davalos & Lab

Excited to share our new manuscript in @NatureMicrobiol uncovering a novel mechanism by which viruses orchestrate their survival in the host. We show that #HIV inherently induces the formation of a latent reservoir of viruses, guaranteeing its long-term survival 🧵 #HIVresearch

Findings by researchers @pryprk @palakmanchanda4 @DavalosLab, Gaurav Chopra, et al. show that excess fat in the brain’s resident immune cells, #Microglia, impairs their ability to combat disease. Learn More in @ImmunityCP 👉 cell.com/immunity/abstr…

Thank you for giving life to our sketch Emma! Until next time!

Emma Vidal brought our concept to life. For more info about the cool science produced in the @chopralab and ours, that inspired our geeky illustration, please read the paper here: cell.com/immunity/abstr…

But blocking or reducing DGAT2 (using a cool new drug developed by @chopralab ) restores microglial phagocytosis of Aβ and thereby reduces plaque load and neuronal damage in a preclinical model of #Alzheimer’sDisease.

Microglia: Super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (weights) & lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)! #NotTheCover @ImmunityCP

Super proud to have been part of this work between the @chopralab and the @DavalosLab that is now published @ImmunityCP !!! Thank you @pryprk, Palak Manchanda, and all authors for this extraordinary collaboration!!!

@sciqst @ImmunityCP Thank you for your kind words! Please check out a paragraph in our discussion on exactly your question: how systemic complications are a serious consideration for manipulations of metabolic pathways in general and why we think DGAT2 may be different @chopralab is on this mission!

This is fascinating research! The role of lipid metabolism in neurodegeneration is indeed gaining attention. DGAT2 inhibition sounds like a promising avenue to reawaken microglial activity. Have you considered potential challenges in targeting DGAT2 without affecting other lipid metabolic processes and their physiological functions? Exploring such questions could be crucial for therapeutic development. For more insights and thorough biomedical reviews, you can visit sciqst.com, a one-stop platform that answers all your biomedical queries. #Neuroscience #AlzheimersResearch

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Check out our manuscript @ImmunityCP 👇🏼 cell.com/immunity/abstr…

@jonykipnis @ImmunityCP Thank you Jony! Gaurav Chopra and an entire village of folks in the @chopralab and mine deserve all the credit!

@DavalosLab @ImmunityCP Congrats, Dimitrios!

@OlegButovsky @ImmunityCP Thank you very much for your kind words @OlegButovsky! We are also very excited to see this through with Gaurav @chopralab and everyone involved with this project!

@DavalosLab @ImmunityCP Dimitrios and colleagues, very interesting findings, would be interesting to see translational directions. Congratulations!

Tremendously grateful to an amazing team of lab members and collaborators including @pryprk , @EviPaouri , Palak Manchanda and Gaurav @chopralab and pretty much all Chopra and Davalos Lab members for the smooth teamwork @ClevelandClinic @CCLRI @PurdueUnivNews

It was💯fun to co-author this commentary w/ Katerina & other current & former fibrinogen mates from @AkassoglouLab for Cell’s 50th anniversary neuroscience issue: @CellCellPress: Pioneering discovery and therapeutics at the brain-vascular-immune interface: cell.com/cell/fulltext/…

We are looking for a technician to help us study #myelin pathology in neurodegenerative disorders - Please RT and ping me if you are interested .jobs.virginia.edu/us/en/job/R006…

Great hosting @fib390_396A for our @CCLRI department seminar tomorrow, awesome dinner with @DavalosLab @2Scottish talking about all things platelets and thrombosis - looking forward to the seminar tomorrow morning at 10 AM, NC1-202

Always have perspective!

Are you doing exciting mechanistic science or translational work? Join us in #Miami! We are looking for independent investigators at all levels! ⁦@ASBMB⁩ ⁦@thepostdoctoral⁩ ⁦@AACR⁩ Faculty Positions - U of Miami ⁦@umiamimedicine⁩ nature.com/naturecareers/…

C. David Allis and Michael Grunstein won the 2018 Basic #LaskerAward for discovering how histone modifications influence gene expression. ow.ly/8O4W50SKpsz @RockefellerUniv @UCLA In just 5 days, we reveal the scientific breakthroughs recognized this year. #Lasker2024

Amazing new study @nature showing that fibrin drives lung inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with acute COVID-19 and long COVID! Congrats @AkassoglouLab & collaborators!