Magali IRLA Lab

🎉🎉🎉 Very happy to see my review out in @AnnualReviews on thymic T cell selection ! If you like T cells check it out !🎉🎉🎉 annualreviews.org/doi/abs/10.114…

@JrmyCSantamaria @CIML_Immunology

Thrilled to share that our review in @ScienceAdvances is out!🧬We highlight how age-related thymic involution alters T-cell immunity and discuss therapeutic strategies to rejuvenate thymic function and promote healthier aging. #immunology #Aging #thymus science.org/doi/10.1126/sc…

Having a great time with the team ! #immunology #CIML

@IrlaLab and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in @ScienceTM. science.org/doi/10.1126/sc…

New work connects #immunosenescence and the decline of the #thymus during aging with a drop in the ligand #RANKL—and shows RANKL treatment restores T cell production and rejuvenates immune responses in aged mice. @IrlaLab @JrmyCSantamaria @CIML_Immunology scim.ag/3ZAqihe

We provide the proof-of-concept that RANKL stimulates human endothelial and epithelial cells using thymic organo-cultures, providing an exciting new therapeutic approach in the arsenal of regenerative medicine to rejuvenate the immune system.

This increased production leads to peripheral T-cell renewal and improves T-cell-mediated anti-tumor and vaccine responses in aged mice.

Thrilled to share our latest research in @ScienceTM ! We show that RANKL administration reverses age-dependent thymic involution and rejuvenates T cell immunity. @CIML_Immunology #aging #thymus #Tcells #Immunology #Involution #Rejuvenation science.org/doi/10.1126/sc…

One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. science.org/doi/10.1126/sc… @ScienceTM

I remember being blown away when @IrlaLab showed me these data @CIML_Immunology 🤯 - Exogenous RANKL substantially reverts thymic involution and improves T cell function in aged mice @ScienceTM science.org/doi/10.1126/sc…

A new study on @ScienceTM finds RANKL treatment can restore thymic function in aged mice and improve their T cell-mediated immune responses. #aging @JrmyCSantamaria, Dr.Magali Irla @IrlaLab, Antoine Toubert of @univ_paris_cite, et al. science.org/doi/10.1126/sc…

@OstuniLab @CIML_Immunology @ScienceTM Thank you Renato 😉

Congrats to @AlexiaBorelli for successfully defending her PhD thesis at @CIML_Immunology ! Her work has advanced our understanding of Foxp3+ Treg development and thymic recirculation, with 2 first-author papers in @NatureComms and Cell Mol Life Sci. #Treg #Thymus #Immuno #CIML

Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk A recent study has found that vitamin D deficiency during childhood accelerates the aging of the thymus, an organ essential for developing a healthy immune system. The thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders, but when it ages prematurely due to a lack of vitamin D, it becomes less effective. This increases the risk of autoimmune diseases like type 1 diabetes, as the immune system may mistakenly attack healthy tissues. The research underscores the importance of adequate vitamin D intake, particularly during "vitamin D winter" when sunlight is insufficient for natural production. Ensuring children receive proper vitamin D supplementation during these months could help prevent autoimmune disorders.

Sex-biased human thymic architecture guides T cell development through spatially defined niches: Developmental Cell cell.com/developmental-…

Review by Pala et al. highlights how novel cutting-edge technologies, incl. high-resolution imaging, single-cell omics & organoid cultures, have improved our understanding of human #thymus biology hubs.la/Q02TfwHP0 📘In our #Autoimmunity collection: hubs.la/Q02TfzFt0

New issue online! This beautiful cover depicts work from @maxim_artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog cell.com/immunity/issue…