OrrLab

Congratulations to the 10 Goodes Prize winners who along with the ADDF have shaped the last decade of #Alzheimers research around the #biologyofaging, moving the field closer to treating the disease with #precisionmedicine. Hope is here. bit.ly/3B9HPTG

NanoString is excited to announce it will be acquired by Bruker Corporation in a $392.6 million agreement. We are grateful for our dedicated employees and customers! #futurelooksbright! bit.ly/3vMCkbz

Thank you @TheADDF for bringing together at#ADPD2024 this impactful roundtable on Novel Approches in AD Research guided by the Biology of Aging with @MiiaKivipelto @jacques_touchon @a_hfillit Miranda Orr @WakeForest @DrJeffCummings

TO ALL #spatial #genomics CEOs! Please read our Comment ⁦⁦@GENbio⁩ “Sounding an Alarm over Spatial Biology” Scientists’ call for action. We are all part one community and have to act accordingly. Don’t let financial interests ruin innovation. genengnews.com/topics/biopers…

.⁦@nanostringtech⁩ is here to stay! Joe Beechem speaks up ⁦@GENbio⁩: “We are not going anywhere”. Only #diversity will drive #innovation in Spatial Genomics! #youarenotalone genengnews.com/topics/omics/n…

I'm curio-s, it may be time to parse on 10x?

It has been fun working with @RCFNeuro, @alzassociation, @CurePSP and other organizers to develop the scientific program for #Tau2024! My lab will be there - will yours? March 25-26, 2024 in Washington, DC. Register now: alz.org/Tau

Thrilled to help @jme_walker and her team explore differences in NFTs between #PART and #AD using GeoMx DSP! Awesome work! #nanostrung

Happy to share our latest publication - we used spatial proteomics to compare #PART and #AD looking at differences between NFTs, normal neurons and their microenvironments in the CA1 and CA2 subregions of the #hippocampus, as well as the entorhinal cortex. doi.org/10.1002/alz.13…

🧟 The @Orr_Lab is researching senescent cells and their impact on memory problems. Could targeting "zombie" cells be a breakthrough in #Alzheimers treatments? Learn more: brnw.ch/21wD7Hq

ADDF-funded @Orr_Lab's #CombinationTherapy clinical trial on senescent cells supports the ADDF's core belief that the next generation of #Alzheimers drugs will be guided by #novel targets based on the #BiologyOfAging. More on the trial in @mcknightsltcn: bit.ly/3rgc2Mq

Last week's 9th Annual Melvin R. Goodes Prize Luncheon & symposium reflected on recent breakthroughs in #Alzheimers research. This year, the ADDF honored DxA-funded scientist, Dr. Rhoda Au for her work with #DigitalBiomarkers and #diagnostics for early Alzheimer's detection.

First feasibility study of orally-delivered #senolytic therapy in #Alzheimersdisease reports favorable safety data and penetrance of #dasatinib into the brain with a modest impact on Alzheimer’s and aging biomarkers @wakeforestmed @MitziMGonzales @Orr_Lab nature.com/articles/s4159…

Research from @Orr_Lab shows that treatment to clear #senescent cells in #Alzheimer’s disease is safe in Phase I clinical trial. Learn more about the study, which appears in @NatureMedicine. @TheADDF @nanostringtech  brnw.ch/21wCn5E

Results from a new study led by ADDF-funded @Orr_Lab further validate that novel approaches to #Alzheimers centered around the biology of aging will guide the next generation of therapeutics. Read our statement on the senescent cell treatment study here: bit.ly/3RdEQjd

Exciting news! Led by @MitziGonzales, our team’s Phase I trial testing #senolytics in #Alzheimer’s disease reports on brain penetrance, safety, and biomarkers! 🧠 Phase 2 trial supported by @TheADDF is underway! #JoinOurStudy #SToMP-AD #Senescence #Aging nature.com/articles/s4159…

@The_CCAD alumni @SusanneVanVeluw @FannyElahi @bucklr01 & mentors Randy Nixon & Alison Goate with @Orr_Lab #AAIC23 #CCAD

A fun day 1 at #AAIC23 with @theREALaivisaur @bbonakda @MaggieFlanagan @Orr_Lab @JohnCraryMDPHD ☺️🧠🍨

@AdamsBioAging @americanaging @WakeForest Thanks so much for including me in your session, Peter! Looking forward to keeping in touch and sharing experiences with CosMx.

@americanaging @Orr_Lab @WakeForest Beautiful work, Miranda @Orr_Lab. Let’s keep in touch over CosMx.

Now speaking is Dr. Miranda Orr (@Orr_Lab) from @WakeForest on the molecular landscape of cellular #senescence in the brain. #AGE2023

Thank you to all who joined the NSC Directors Symposium at #AGE2023! The session featured presentations from pilot grantees George Sutphin @senmorteco, Miranda Orr @Orr_Lab, Andrey Parkhitko, Anna @ThalackerMercer, Danielle Bruns, @SimoneSidoli, @MariaMMihaylova, & @CristalM_Hill