Thyroid Journal

The March issue of @ThyroidJournal is now available online! ow.ly/fHpN50Yx0Vi #AmericanThyroidAssociation #ATAthyroid2026 #ThyroidJournal #endotwitter #medtwitter

How do BRAFV600E & TERT cooperate in aggressive thyroid cancer? A new @ThyroidJournal study identifies DDX21 as the molecular link—upregulated via MEK/ERK/GABP, interacting with TERT to drive rRNA transcription and tumor progression. ow.ly/e1M150Ys4Bi @AmThyroidAssn

How do patient beliefs shape experiences after radioiodine? A new @ThyroidJournal prospective study found poor recall of required precautions, frequent self-imposed restrictions & reported side effects—often linked to pre-treatment beliefs. ow.ly/CLjf50Ys4m2

Is AI transforming thyroid cancer diagnosis? 2026 update @ThyroidJournal reviews FDA-cleared tools for ultrasound, emerging platforms for lymph nodes & pathology & key considerations for implementation—IT, usability, effectiveness, vendor support & cost. ow.ly/Bjpm50Ys3PJ

How do patients decide on surgery for low-risk #thyroidcancer? A @ThyroidJournal study found shared decision-making hinges on tailored info, desire to limit surgery/avoid lifelong hormones & clinician recommendations- guiding better decision-support tools. ow.ly/TKaM50Ys3ht

What is the risk of hypothyroidism after hemithyroidectomy in children? What if you carry TPO antibodies? New study from @BostonChildrens who found ~28% develop persistent hypothyroidism with higher risk if TSH ≥2 and + TPO antibodies. ow.ly/gtUq50Y1TpW @AmThyroidAssn

Can unstimulated thyroglobulin predict recurrence after thyroidectomy without RAI? A team from Korea studied nearly 10,000 patients & found Tg cutoffs (≥0.2 and ≥5.0 ng/mL) and rising Tg over time strongly predicted structural recurrence ow.ly/WkZU50Y1TfP @AmThyroidAssn

Can #ALK inhibition improve outcomes in ANAPLASTIC thyroid cancer? New study from Germany using an ALK-driven, p53-loss ATC model showed ALK inhibitors suppressed signaling & markedly prolonged survival—supporting ALK as a therapeutic target in #ATC. ow.ly/ALov50Y1Tar

Does teprotumumab reduce the need for further treatment in TED? New @ThyroidJournal study found similar treatment rates vs IV steroids. IVMP led to more complex, multi-step care, while teprotumumab simplified treatment pathways ow.ly/fQaE50Y1SJ5 @AmThyroidAssn #medtwitter

Can subcutaneous levothyroxine help with severe oral malabsorption? New report from Singapore showed excellent absorption— approx 9× oral bioavailability—with rapid TSH normalization, supporting SC levothyroxine as effective alternative. ow.ly/BC3f50Y1SoQ @AmThyroidAssn

Does weight gain after treating hyperthyroidism affect quality of life? A new @ThyroidJournal study found post-treatment weight gain was linked to worse QoL, highlighting the need to address weight changes in care. ow.ly/p8MQ50Y1RV9 @AmThyroidAssn #medtwitter #endotwitter

Does hypothyroidism affect mortality risk? Does it matter if it is overt or subclinical? An association was found with both in a new large Chinese cohort study which investigates this association in @ThyroidJournal. ow.ly/boQ550XSIfe @AmThyroidAssn #medtwitter #endotwitter

Does thermal ablation improve quality of life for benign thyroid nodules? New meta-analysis by @UMmedschool in @ThyroidJournal suggests QOL often improves, results vary by domain & study heterogeneity limits comparability. ow.ly/c9L550XSEmv @AmThyroidAssn #medtwitter

What predicts survival in primary thyroid lymphoma? @ThyroidJournal study from Tokyo found mortality highest in 1st 6–24 months, with older age & DLBCL subtype linked to worse outcomes; selected Stage IE patients did well with local Rx, including surgery. ow.ly/jbkh50XGAws

What are normal free T4 levels across the lifespan? A new @ThyroidJournal study by @QuestDX established age-specific reference intervals from birth to 100 years using direct dialysis—helping clinicians interpret FT4 results accurately at all ages. ow.ly/oa5s50XGAjQ

What’s New in the 2025 ATA Differentiated Thyroid Cancer Guidelines? Don't Miss the 2025 ATA Guidelines for Adults with #DTC Webinar on Jan. 22. Reserve Your Spot Now: ow.ly/7uHH50XMMSO #ThyroidEducation #Thyroid #ThryoidCancer @thyroidjournal @clinicalthyroid

Telomere-regulating gene variants have been shown to increase thyroid cancer risk. However, @ThyroidJournal study in a Saudi population found no association in sporadic or familial cases, highlighting potential ethnic differences in TRG variant effects. ow.ly/6Wvf50XGAcq

Does the International Medullary Thyroid Carcinoma Grading System predict outcomes in metastatic MTC? A @ThyroidJournal study (France) validated IMTCGS—high-grade tumors (or Ki-67 ≥ 20%) had markedly shorter survival, confirming its prognostic value. ow.ly/VOsS50XGA66

What’s the global consensus on remote-access thyroid & parathyroid surgery? A new @ThyroidJournal statement from 6 major intl societies outlines patient selection, training, and approach-specific guidance—endorsing safety, efficacy & cosmetic outcomes. ow.ly/Qz1O50XGzXi

Do lymph node thresholds predict outcomes in medullary thyroid cancer? A new @ThyroidJournal from @DukeMedSchool study found ≥8 positive nodes or a lymph node ratio ≥14% significantly increased MTC-specific mortality—supporting nodal metrics in staging. ow.ly/iZfC50XsZr4