Frank Doss MD,PhD

This is an introductory 550 page Document of updated references covering many aspects of the SARS-2 genome intended for Medical and Science students and for researchers. docs.google.com/document/d/10o… Who is mightier? The tiny vs the enormous.

@Nicensteiner Why did it take so long to recognize that SARS-2 is a respiratory illness as well as a multi-systemic one when evidence of this was accumulating years ago?

Read this as many times as you need. mdpi.com/2673-8112/5/9/…

MRIs TO SLOW DOWN and off with ballooons? Liquid helium at -269 deg Celsius is critical requirement to cool the superconductor magnets of MRI devices which need 2000 liters each and hospitals have limited supplies. Hospitals also use helium in breathing mixtures (Heliox) and in some smaller devices and procedures. Slow down on the parties with balloons!

The head of Europe’s central bank just said financial markets don’t understand what they’re in for. This is Christine Lagarde saying the damage is already done. Most people have absolutely no idea. Here is what she actually said. Iran closed the Strait of Hormuz. That chokepoint carries 20% of the world’s oil and gas. Markets shrugged. Investors assumed it would blow over. Lagarde told The Economist that technical experts are not talking about months for recovery. They are talking about years. Helium travels through the Strait of Hormuz. Helium is not a balloon gas. It is the invisible ingredient inside every advanced microchip on earth. Qatar supplies 35% of the world’s commercial helium. Qatar’s facilities have gone dark. Spot prices have surged past $450 per thousand cubic feet. Most chip fabricators carry less than three months of inventory. The world is building AI data centers at record speed. The raw material that makes the chips possible is now scarce. Meanwhile Brent crude has hit $99. Earlier spikes passed $120. US gasoline is up 30%. Iraq cut 1.5 million barrels a day. Saudi Arabia paused its largest refinery. Europe is heading into this with gas storage at 30% capacity. And the ECB is not cutting rates to soften the blow. It is considering hiking them to fight inflation. Slow economy. Rising prices. Tighter money. All at once. Gandalv / @Microinteracti1

@scitechgirl This is misleading. From the information available, the Tsinghua Agent Hospital is treating only simulated (virtual) patients not humans, at present.

Reference: CHINA: the world’s first AI hospital staffed by 42 AI doctors neurosurgical.tv/china-the-worl…

@HarrySpoelstra SARS-2 is not the only virus found in brain tumors of humans. Many viruses ,often DNA, and particularly h cytomegalovirus antigens and DNA are frequently detected in glioblastomas. nature.com/articles/s4169…

SARS-CoV-2 infection in brain tumors and the association with alterations in the tumor immune microenvironment 🚨INTERESTING Chinees study analysed brain tumor samples from 72 COVID-19 patients during the SARS-CoV-2 BA.5 wave with a SURPRISE! ➡️Current study provides the first human-tissue evidence that SARS-CoV-2 can infect various primary brain tumors. ➡️Findings: 1. SARS-CoV-2 RNA detected in 11% (8/72) of tumors, including craniopharyngiomas (50%), PitNETs (21%), meningiomas (11%), and gliomas (8%), 2. Virus infected tumor cells and endothelial cells, using alternative receptors (NRP1/CD147) rather than ACE2/TMPRSS2, 3. Positive tumors exhibited significantly greater immune infiltration: increased CD8+ T cells (especially in gliomas and PitNETs, P<0.001), CD68+ macrophages (P=0.040), and IFN-γ+ effector CD8+ T cells, 4. RNA-seq showed complement cascade activation (e.g., C1q, C3 upregulation), innate immune responses, and suppression of oncogenic pathways (e.g., WNT), 5. Complement deposition correlated with higher macrophage and CD8+ infiltration, suggesting a shift from immunosuppressive to more activated tumor immune microenvironment (TIME). ‼️So, SARS-CoV-2 can directly infect brain tumors and paradoxically enhances anti-tumor immunity via complement-driven immune activation, potentially opening new immunomodulatory therapeutic opportunities for these patients. 🤔🤔🤔I didn’t see this coming! ‼️Important personal remarks: - It confirms viral tropism beyond respiratory tissues, extending to neoplastic cells in the brain, - Direct infection correlates with profound remodeling of the tumor immune microenvironment (TIME), - Study adds mechanistic support to scattered anecdotal reports and case series of spontaneous or accelerated cancer regression post-COVID-19, - Broader implications could include possible viral reservoirs in tumors. ‼️A further important take-way: This study is certainly not universally positive: most literature emphasizes worse COVID-19 outcomes in cancer patients (higher mortality, severe disease due to immunosuppression), potential pro-oncogenic effects via chronic inflammation/long COVID, and accelerated progression in subsets. ‼️So, direct SARS-CoV-2 infection of tumor cells is a double-edged sword, it can paradoxically ignite anti-tumor immunity in select cases (offering intriguing therapeutic hints), but overall evidence still weighs far heavier toward harm than benefit for cancer patients, with possibly a new viral persistence site! cancerbiomed.org/content/early/…

These authors used proteomic studies on 412 sera: healthy, Covid :acute and at 1,3,12 months post infection to detect incorporated noncoding AAcids (ncAAs). 827 of ncAAs were present across 1685 proteins at 30,000 sites especially in antigen binding IGs interfering with their functional activities and also in complement factors but less persistently in coag factors. These changes indicate persistent dysregulation of dysfunction of critical proteins by "protein scarring" rather than a "pass through of the virus" or gene modification. t was also possible to differentiate between normal, acute Covid and stages in convalescence by their ncAAs panels. mcponline.org/article/S1535-…

@DrNeilStone Look at the data of deaths due to Covid disease from 2019: In unvaccinated versus in the vaccinated even including deaths attributed to the vaccination. Massive numbers died due to Covid before the vaccines were made available.

"Everybody who has an mRNA injection will die within 3 to 5 years, even if they have had only one injection" said Delores Cahill Anyone out there 5 years or more after the vaccine and still alive? ✋

From the time of Mao, China has been consistent in executing a policy of prosperity for the people , while allowing private companies and individuals to get rich but within limits bc the Govt has controlling influence on all boards: example AliBaba and Ma. All enterprises such as banking , having major influence on the economy are state owned so that vital sectors will not get crashed by the games played by private individuals anymore. Some such s Huawei are completely owned by present and past employees. These efforts have raised millions ?800 of people from poverty but the aim is not only that but prosperity for all in the next few years. The administration is planned centrally but are executed peripherally in the provinces which compete for growth allowing more centralization in autonomous regions. Money is allocated for defense and not for precipitating wars . Many industries are automated planning for the ageing population. China is divesting investment of cash in the Belt initiative and in precious metals diminishing treasury holdings. The growth in prosperity and preservation of the multi millennial culture is for all, who wish to see, to see.

Let's be real, China isn’t an enemy. It’s simply a competitor of the US and now the leading economic power. Why? China didn’t waste trillions on endless wars. They invested in innovation, manufacturing and education. US politicians hate China’s success because it makes them look like clowns.... 🤡🤡🤡 (Matthew Whitaker, US Ambassador to NATO)

@OliiviiaMorgan x.com/Dapper_Det/sta…

Crazy! This will usher in a whole new era for the medical field!

@JohnSitarek @clashreport More than 50% of London's well known black cabs LEVCTX are now hybrid low emission electric made by Chinese company GEELY ,from 2017 ,in Coventry. This has reduced air borne emissions in London. Robotaxis ae planned. Any regrets?

@clashreport Starmer walk matches the media headline

Keir Starmer has arrived in China.

@OANASA_X_ Big bat big Covid agent!

😱📹 Strange Animal Sighting Caught on Camera Is it an unusual animal? 👀

China is issuing US$ denominated bonds probably backed by their US$ reserves. This bypasses the US treasury because the entire financing and interest are outside of the US treasury ,investors buying this instead of US treasuries. States can issue bonds in currencies other than their own.

@RadarHits @BitcoinArchive How is issuing USD denominated bonds a challenge to the US? That action supports US supremacy over the financial system

JUST IN: 🇨🇳 China now issuing USD-denominated bonds at the same yield as the U.S. Direct challenge to the United States

AI appears to flourish in environments with fewer lawsuits as in China where the patient volumes are huge. A large hospital in Shanghai treated 850,000 cardiology outpatients in a year. They collaborated from 2024 with Fudan university , Huawei, Tencent and Alibaba with multi agentic AI and even avatars to produce "Cardiomind" and other software for history taking, ECG ECHO MRI CT leading to a diagnosis and treatment, the final stages subject to Doctor supervision. WeChat alert is available to patients as when arrhythmias or cardiac emergencies are detected. They claim high degree of accuracy in the use of algorithms in their population. Tsinghua University Agent Hospital is a total AI hospital treating AI patients on a trial basis. However, such extensive use of AI appears to be restricted to certain centers. Perhaps Physicians are less liable to face lawsuits which still exist in China with smaller awards.

The AI hype this week has been unbearable. Humor me: who gets sued when the AI hallucinates in regulated, mission critical environments?

This may relate to legal responsibility. Perhaps Insurance companies act in an advisory capacity to Physicians and not to patients to whom they owe no responsibility. Fixed income raters such as Moody's, S&P ,Fitz are responsible only to the bond issuers who are the clients not to the buyers. Accountants such as Deloitte, KPMG,PWYC are responsible to the Corps and not to the investors : stocks may tumble due to irregularities days after high grades eg Enron, yet they bear no responsibility. These agencies are cartels which connive with each other for business ensuring good grades to clients. The lack of fiduciary responsivity in the health insurance sector will ensure that they will thrive at the expense of patients.

“The act of signing a denial is practicing medicine.” — Dr. Tracey Hurley If a physician makes a medical decision and that decision harms a patient, we are held accountable. That is how medicine works. Yet insurance companies make treatment decisions every day through denials and prior authorizations, without ever seeing the patient and without meaningful accountability when those decisions cause harm. In this powerful investigation, Erin Moriarty of 48 Hours examines how insurers are increasingly inserting themselves into medical decision making, often driven by profit rather than patient safety. Millions of Americans are paying high premiums, facing crushing deductibles, or being denied medically necessary tests and treatment. Even physicians who understand the system are forced to fight for care while patients are fighting for their lives. In this interview, Dr. Tracey Hurley shares what it looks like on the inside. You will hear how denials impact families, why prior authorization has become a tool for rationing care by inconvenience, and what happens when delays are treated as neutral instead of dangerous. This story matters. It shows what happens when insurance companies practice medicine without accountability. We owe it to the late Dr. Hurley and to every patient who did not have the time, energy, or resources to keep appealing. This should not be normal. I hope you will watch the full interview (cbsnews.com/video/state-of… ) and share it. Change only happens when we stop accepting this system as inevitable. Thank you CBS, Erin Moriarty, and Sari Aviv for covering this story and bringing these voices forward.

COINFECTION with FLU A/B ,RSV and other RESP viruses in acute COVID. There are numerous reports of dual respiratory viruses infecting pediatric or elderly patients either simultaneously or in immediate sequence in acute Covid or as in rare reports in long Covid. The infecting viruses may interfere with each other either at the cellular level or at the innate response. Recombination events have not been shown to occur in patients although these have been shown in vitro eg RSV and flu A. However, the end result is usually severe clinical course requiring carefully targeted therapy. link.springer.com/article/10.118…

@mcm_ct_usa How can we be sure that at least some of these banks are not hoarding large amounts of physical metal hidden from scrutiny manifesting only the paper, to profit immensely later? Time will tell.

The eight banks trapped in the $silver squeeze (and $gold), are: Watch them closely 1. JPMorgan Chase 2. HSBC Holdings 3. Scotiabank 4. BNP Paribas 5. UBS Group 6. Deutsche Bank 7. Citigroup (Citibank) 8. Goldman Sachs

@BullTheoryio The US could revalue gold at current values or revalue it higher then sell it and buy back the 30 year debt now at 4.8% or lease the gold to earn income.

🚨The U.S. is sitting on nearly $1 TRILLION worth of hidden liquidity that could be unlocked without QE. If that happens, risk assets will explode. Let me explain how👇 The US Treasury owns about 261.5 million ounces of gold. But on official books, that gold is still valued at $42.22 per ounce, a price set in 1973. On paper, this makes US gold reserves look worth only $11 billion. In reality, gold is trading near $4,500 per ounce today. At current market prices, the same gold is worth over $1.17 trillion. That is a hidden gap of more than $1 trillion sitting quietly on the US balance sheet. This is basic math. Why does this exist? When the US left the gold standard in the early 1970s, the official gold price was frozen. Congress never updated it. Most other countries value gold at market price. The US does not. That means the US is holding a massive unrealized gain that does not show up in headlines. Why does this matter now? US debt is over $37 trillion. Interest costs are exploding. Deficits are structural, not temporary. At the same time, the US government is running out of easy tools. - Raising taxes is politically not possible. - Cutting spending is unrealistic. - Issuing more debt pushes yields higher. This is why the hidden gold value becomes important. If the US ever decides to revalue its gold closer to market price, that $1+ trillion gap can be used to strengthen the Treasury balance sheet without issuing new debt. This has happened before. In 1972, the US revalued gold slightly and injected money directly into the system through the Treasury account. No bonds. No QE. Just liquidity. Today, the scale would be much larger. At current prices near $4,500/oz, revaluing gold would instantly add over $1 trillion of usable balance sheet capacity. That would act like stealth liquidity entering the system. What would the market impact be? First, it would be an admission that the dollar has lost purchasing power. That alone is bullish for hard assets. Gold would move first, because it is directly repriced. Risk assets will follow. More balance sheet room means more spending flexibility. More liquidity means higher asset prices over time. Bitcoin benefits the most from this logic. Gold revaluation tells the world one thing very clearly: - Fiat currencies are being managed, not preserved. - Bitcoin is the only major asset that sits outside that system. That is why gold usually moves first. Bitcoin follows once the signal becomes obvious. The US is sitting on a $1 trillion+ hidden asset created by outdated accounting. If this lever is ever pulled, it would quietly inject liquidity, weaken the dollar in real time and push hard assets higher

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@WallStreetMav According to ChatGPT every ounce of silver is now hypothecated to 378 certificates. This entitles 378 certificate holders to have a claim on the same ounce of silver! What a fraudulent conspiracy if this is true!

Silver is now up almost 10% today. Over +170% YTD. +$50 oz so far this year. $28 to $78 There are several factors involved. 1) Starting Jan 1st, China has export restrictions on silver. China is the 2nd largest producer of silver in the world. 2) Globally, silver mines are not keeping up with silver demand. 5 years in a row demand has exceeded what the mines can produce. Industry has been consuming silver that was above ground in vaults. That supply is getting tight. 3) Companies like Samsung are going direct to silver miners and signing deals to buy silver production for years into the future. They are securing supply for their electronics manufacturing, which requires silver. 4) There is no way for mining companies to increase the supply of silver. Silver is mostly a biproduct of copper, lead or zinc mining. Mining companies get maybe 1% to 2% of their revenue from silver. They are not opening new mines because of silver prices. They don't care, it is not meaningful to their revenue. 5) There are very few primary silver miners that get more than 50% of their revenue from silver. It is limited to a handful of stocks. The two that I own are Aya (AYASF) in Morocco and Silver X (AGXPF) in Peru. 6) Gold is up over 70% YTD, but silver is up over 170% YTD. Gold is a monetary metal, but it isn't really consumed. It is only used for jewelry, which can be easily recycled back into a gold bars. Silver is actually consumed by industry, into electronics and other products. And much of it cannot be recycled. It is used and those obsolete electronics are often dumped into a landfill. That silver will never be recovered. They have tried, it is not profitable to recover the tiny amounts of silver in those products. But it adds up to hundreds of millions of silver oz per year, lost forever. What does it all mean? Silver is a critical metal. It is the best conductor of electricity on the periodic table. And we don't have enough of it.