Stone Cold Pillar

“How to Hide a Pandemic”, by Rochelle Walensky Forward by Ashish K. Jha Updated with new chapter by amateur social media influencer Mandy K. Cohen! Funded by Delta Airlines, American Association of Commercial Real Estate, and the Koch Brothers

@martinfinne @sunsopeningband Do you have a link to a paper for the mast/il cell communication?

@sunsopeningband That someone is wrining on how mast/il-cells communicate systemic an even use fascia as both medium an regulator of activity. (Core fibromyalgia it seems.) Also, how microbiome regulates this activity level in mc. So they need to know this: nature.com/articles/s4200…

I have a webinar in a couple of days as a guest lecturer in a class of first year DPT students at another school. Topic is Long COVID. What would you want a bunch of bright young people to know at the very beginning of their journeys toward becoming clinicians?

"Immune Cell Tied to Long COVID Fatigue Found" 'Their large-scale data analysis pointed to a distinct molecular state in a type of white blood cell known as CD14+ monocytes, which play a key role in immune defense.' miragenews.com/immune-cell-ti…

@HarrySpoelstra @threadreaderapp unroll

Post-COVID-19 Cardiovascular Complications: An Updated Systematic Review 🚨GENERAL WARNING AGAIN! Long COVID is silently wrecking hearts, even after mild cases, years later! And the worst part, this isn't over. #LongCOVID #HeartHealth ➡️This Romanian systematic review synthesizes evidence from 10 high-quality studies (2020–2024) on cardiovascular complications in long COVID, drawing from diverse cohorts (mild to severe cases, including non-hospitalized patients). ➡️IMPORTANT FINDINGS: 1. Long COVID is linked to subclinical myocardial dysfunction, including reduced left ventricular ejection fraction (LVEF <50% in ~8% of cases) and impaired global longitudinal strain (GLS abnormalities in ~15%), 2. Increased arterial stiffness (e.g, pulse wave velocity +1.2 m/s, arterial stiffness index +18%) and endothelial injury persist, even in younger, previously healthy individuals, 3. Arrhythmias (new-onset in >8%, fragmented QRS, ECG changes in ~15%) and prothrombotic states are common, 4. New-onset hypertension affects ~32% at 1-year follow-up, associated with acute disease severity, steroid use, and age >60, 5. Elevated cardiac biomarkers (e.g., troponin in 7%) and symptoms like palpitations (10–15%), chest pain (~12–15%), and fatigue/dyspnea occur across severities, 6. Large-scale data show elevated risks vs. post-influenza (e.g, 1.6–2.3-fold higher for arrhythmias, heart failure, thromboembolic events in elderly), 7. Vaccination appears protective to some degree, reducing persistent symptoms and some complications, 8. Mechanisms involve myocardial inflammation, endothelial dysfunction, autonomic imbalance, RAAS dysregulation, and chronic inflammation. ➡️ Long COVID is a heterogeneous entity with substantial cardiovascular implications across all levels of acute disease severity. ➡️ Early detection through longitudinal monitoring, standardized definitions, and multidisciplinary care is essential to reduce long-term cardiovascular risk. ‼️So, AGAIN, Long COVID poses a substantial, underappreciated long-term threat to cardiovascular health, even in mild cases, demanding routine monitoring and intervention to avert future heart disease burdens. ‼️AND for all those still sleeping, my personal reminder: Reinfections aren't harmless, they stack the deck against your heart, turning one hit into compounding long-term cardiovascular threats. #Mitigation #CleanAir #AVOIDREINFECTIONS #AVOIDSARS2 mdpi.com/2673-527X/6/1/4

@ZdenekVrozina @threadreaderapp unroll

Pawłuszkiewicz at al., COVID-19 Impact on Lipid Profile and Metabolome in Patients with Type 2 Diabetes Mellitus: Mini-Review. eurekaselect.com/article/153034

This new study shows that SARS-CoV-2 can systematically reprogram cellular metabolism to support its own survival. This isn’t just tissue damage. It’s a redirection of the body’s energy systems🧵

@ZdenekVrozina @threadreaderapp unroll

ME/CFS is sometimes framed as a body locked in stress mode. The sympathetic nervous system permanently switched on. Fight-or-flight with no way out. It made sense. Almost too much sense🧵

@mecfsskeptic @threadreaderapp unroll

6) Link to the study: Gan et al. 2025. Age-specific alterations of the gut mycobiome in patients with myalgic encephalomyelitis/chronic fatigue syndrome and identification of potential diagnostic biomarkers. link.springer.com/article/10.118…

1) 🇨🇳 A Chinese study looked at the mycobiome, the fungi living in the human body, in 59 ME/CFS patients and 59 controls. Patients had, for example, more Aspergillus and less Candida.

@FullLaneFemme Maybe check in with RTHM Direct? rthm.com/resources/blog…

If someone wants to take 500mg of metformin to help avoid long COVID, what's the dosage and length of time they need to take it? 2x a day for two weeks? A month?

@mecfsskeptic @threadreaderapp unroll

9) Link to the paper: Heng et al. Mapping the complexity of ME/CFS: Evidence for abnormal energy metabolism, altered immune profile, and vascular dysfunction. cell.com/cell-reports-m…

1) 🇦🇺 This new study tested the kynurenine pathway in the plasma of 61 ME/CFS patients and 61 controls. There were no differences in tryptophan or kynurenine, but further downstream, patients had increased levels of 3HK and lower levels of picolinic acid and quinolinic acid.

@SGriffin_Lab 💯 #WearARespirator 🦠Pls share🧵👆🏼 #FFP2/3 #N95 #MedEd #MedTwitter #VetTwitter #Medstudent #NurseTwitter @scott_squires @doctor_oxford @catladyactivist @drcrystalheath @StoneColdPillar @calirunnerdoc @LauraMiers @keetmuise @lavika @dupuisj @CaliforniaCodes 🙏🏼@SGriffin_Lab

@fitterhappierAJ @UnrollHelper unroll

Also, all those claiming that the studies aren't consistent with their lived experience are no different than the anti-Vaxxer's anecdotes about how Timmy doesn’t have infections and has had no vaccines.

The claim Long Covid rates would reduce upon reinfections were made by Iwasaki, Zeynep, and others When I said I believed the opposite I was derided and mocked Three studies now show increasing rates of Long Covid on reinfection 🧵 twitter.com/fitterhappierA…

@Mike_Honey_ @threadreaderapp unroll

Here’s the paper: Persistent Attenuation of Lymphocyte Subsets After Mass SARS-CoV-2 Infection Jiang, Zhengqi et al. International Journal of Infectious Diseases, Volume 0, Issue 0, 108287 doi.org/10.1016/j.ijid… 🧵

A recent scientific paper explored the impact of mass SARS-CoV-2 infections on Lymphocytes (crucial to the body’s immune system). I noticed the authors had shared the data behind their charts in the Appendix Supplementary materials, so I built a quick dataviz project. 🧵

@JackHadfield14 @amaticahealth @UnrollHelper unroll

@amaticahealth Full article: healthrising.org/blog/2025/12/0…

New research shows major damage in the brain stress system of people with very severe ME/CFS. The key finding: a near-loss of the neurons that start the cortisol stress response. This helps explain low cortisol and many symptoms. Let’s break it down in simple language.

Google wants you to use their cloud storage to keep your sensitive data and photos, because they claim it's "secure" and "encrypted". Our pinned tweet says otherwise.

What takes years with HIV or CMV, SARS-CoV-2 can partially induce after only a few reinfections - because it targets the same regulatory and metabolic axes of immunity.

@JackHadfield14 @threadreaderapp unroll

Study link: onlinelibrary.wiley.com/doi/10.1002/ct…

New research has identified a potential biological cause for post-COVID fatigue/muscle fatigue. Scientists found that a molecule called soluble IL-2 receptor (sIL-2R), linked to immune activation, may directly harm mitochondria in muscle cells.

@ZdenekVrozina @threadreaderapp unroll

Gao at al., Alterations in the serum metabolome in patients with the COVID-19 Omicron variant and in recovered cases. journals.plos.org/plosone/articl…

Even though Omicron often causes milder illness, it leaves a clear metabolic footprint disrupting liver, immune, and energy metabolism. A new study shows that even 2-4 weeks after recovery, the body does not return to normal metabolic state🧵

🚀We (Clean Air Allies) are launching a Youth Video Contest about IAQ in schools starting Nov. 1.🚀 @cleanairschool 🙏We need your help to make it happen!🙏 Donate a few bucks💵 to help us build up our cash prizes. Details: givebutter.com/w2UrzY 🧵

Long COVID symptoms can last for weeks, months or even years. These symptoms can be mild or severe. Learn more about how to manage long COVID and how you can support someone living with long COVID: nyc.gov/longcovid

@CAPublicHealth @lapublichealth

It’s not his house. It’s your house. And he’s destroying it.