Tomas Barreto

Across basically all scaling early-stage startups I know (even now in the age of AI codegen) - there is always an unsung hero infra/security engineer who is a key part of fixing every severe outage. Early days @scale_AI it was Calvin Huang. Who are other good examples of this?

Excited to finally share more about KP’s first incubation since Glean: @RoadrunnerAI. Building this company with Ajay Natarajan, Eugene Shao, and our incredible team has brought me the most energy I’ve ever felt in my career. Grateful to @kleinerperkins and @mamoonha for backing this - and for letting us build upstairs in the SF office for the past several months 😬. Huge thank you to our design partners who took an early bet on us to codevelop a solution that finally fixes CPQ. We marked the moment by flipping the script on the @KPGrit podcast. Mamoon interviewed me about my story and how many unlikely turns ended up pointing toward Roadrunner. If you’re interested, reach out. I’ve never seen this level of pent-up customer demand, and I’ve never seen an engineering team ship with this level of velocity and craft.

Working with the next household name in this list (currently ~Series B stage), where a staggering ~1/3 of the team is former founders. They are hiring! Message me for details.

We're heading west to San Francisco! 🌉🇺🇸 When @thejamescad and I met in the hallways of @southpkcommons in New York City, we knew that whatever we decided to dedicate the next 10 years of our life would be built in NYC. In the past 14 months, we've grown @tryprofound from just two people with laptops into a thriving business with 82 teammates, serving 1,000+ enterprise customers across three offices. Now we're opening a new office in San Francisco dedicated to Tech & GTM.

🚀 Applications for KP Fellows 2026 are open! Spend your summer at a world-changing Bay Area startup. Apply here: jobs.ashbyhq.com/kleinerperkins… #KPFellows

We are doing the first incubation at @kleinerperkins since @glean and looking to bring on the initial technical team. The CEO is a partner at KP with the most clear unfair advantage I’ve seen in a long time. Please ping me if interested!

KP Fellows szn

want to be a @kleinerperkins fellow? come work @browserbase! excited to share we have TWO KP fellows on our team this summer: @endpoint and @kylejeong. well deserved!

We've raised a $64M Series A led by @kleinerperkins to build the platform for real-time voice AI. We'll use this funding to expand our team, and to build the next generation of models, infrastructure, and products for voice, starting with Sonic 2.0, available today. Link below to try it free 👇

KP Fellows 2025 applications are open for 2 more weeks! This program identifies the top technical university talent and connects them with internship opportunities in our portfolio. Accepted applicants will get access to exclusive events with industry leaders and join a community of ambitious and entrepreneurial rising stars in the bay area for the summer. Apply today! 🚀 (link in the comments)

The KP Fellows 2025 application is now open through January 31st! We are searching for the next generation of up and coming leaders to join this KP Fellows cohort. If you are an engineering student eager to work on meaningful problems, apply to the KP Fellows Program: ⭐️ Hands-on (paid) experience at a partner company ⭐️ Mentorship from founders / industry leaders ⭐️ Be part of a high performing tight knit group of peers ⭐️ Lifelong support for career and entrepreneurial endeavors ⭐️ 1,000+ alumni community Apply today! 🚀 (link in the comments)

I met @_dan_lee_ at @scale_AI years ago. Dan always impressed me with his ability to focus on the customer. That focus led him & the @JoinNooks team to bring AI to sales teams in a human-centric way. We’ve met countless customers who couldn’t go back to life without Nooks — the usage and results speak for themselves, and we’re excited @kleinerperkins to be part of the journey.

@Alan_Couzens Maybe another 50 at 50 goal? Sum of 6 skinfolds under 50mm.

"Hi Alan, What are the 6 locations used for the sum of 6 skinfolds? Thank you!" 1/ Triceps - midpoint back of arm - vertical 2/ Subscapular - below bottom of shoulderblade - diagonal 3/ Supraspinale (OUCH!) - just above the top corner of pelvis on a line from the armpit - diagonal 4/ Abdominal (Double OUCH! 😊) - 5 cm to the right of the belly button - vertical 5/ Front Thigh - midpoint - vertical 6/ Medial Calf - inside calf at largest circumference - vertical.

@Drlipid Thank you! Loved your masterclass series with @theproof. It's how I discovered @empowerDX and got motivated to start treating this early! 🙏

@tomasrb Yes, indeed. At that point, instead of pushing higher statin dose, one could try other apoB-lowering medications that do not affect brain cholesterol synthesis: ezetimibe, bempedoic acid, PCSK9i

Better to ignore the colors and the "Normalized Value" (Sterol/TC in molar concentration). What matters most in an INDIVIDUAL patient is the absolute concentrations. In this case lathosterol is 45th %tile, desmosterol 20th %tile, sitosterol 55th %tile & campesterol 35th %tile. So, there is NORMAL synthesis & absorption. Only issue is if one is on a statin & an E4 allele is present - not wise to let desmosterol (a biomarker of brain cholesterol synthesis which correlates with cognition and AD) drop < 20th percentile. To reduce apoB a low dose statin + ezetimibe would be appropriate and if needed (depends on desirable goal) ultimately a PCSK9i

@Springandashura @Drlipid Definitely, here it is: ncbi.nlm.nih.gov/pmc/articles/P… and a follow up from Sato in 2015: ncbi.nlm.nih.gov/pmc/articles/P…

@tomasrb @Drlipid Care to share the paper?

@Drlipid @BostonHeartDX @empowerDX @society_eas @docsanz Thanks for the great post! My ApoB is 134 and it looks like I’m both a hypo-synthesizer and hypo-absorber (no treatment yet). Does this indicate that liver clearance/ldl receptors are the primary issue and PCSK9 inhibitors would be a promising intervention?

"Hyper-response" to statins typically occurs in those who are hyper-synthesizers of cholesterol (check lathosterol & desmosterol levels before Rx) or those with hypo-absorption (sito- / campesterol). Tests are available @BostonHeartDX or DTC at @empowerDX @society_eas @docsanz

@BobTroia @Alan_Couzens This or grip strength of > 50kg using a hand dynamometer? pubmed.ncbi.nlm.nih.gov/35445560/

@Alan_Couzens What about adding grip strength ("50 second hang")?

A strong case has been made for the addition of a strength/muscle-based event to our "Old man Olympics", so I propose we add... 50 consecutive push-ups. Going by ACSM's norms, this is actually tougher than the VO2max standard, with >39 consecutive push ups being a 95th percentile performance for a 50+ yo male, but our dude looks pretty buff. I don't think he'll have a problem with it 😊

@feelthebyrn1 Really helpful post! Where is your LT1 on each of the 5 tests? (on the 8/2023 test would it be ~210W, ~225W or somewhere else?)

Building Metabolic Fitness Metabolic fitness is the foundation of your Endurance Journey How do you get this done? Track your fitness with periodic lactate testing: ✅10 minute steps ✅Kick'r bike in erg mode Tips: 1⃣ Start too easy 2⃣ Size up the lancet (28 gauge for me) 3⃣ Spear the 3rd drop, don't touch skin THEN: 1⃣Find Your 1st Lactate Threshold (LT1) - the highest power/pace you can manage without lactate rising. One year ago, my lactate was rising immediately. My heart rate was ~60 beats below max. Now, it's rising ~40 beats below max. My easy zone covers 65% of my heart rate reserve. 2⃣ Train Easy - the humility to develop our low end is not helped by the constant discussion of which high intensity protocol to use. Focus on building General Capacity, first. 3⃣Whole Body Fitness - best in class metabolic fitness is whole body fitness. Flatten your lactate curve. Ideally by moving it down down, and to the right, in everything. 4⃣ Consistent Green Zone Volume - the faster we rack up 90+ minute sessions of easy volume, the faster our metabolic fitness will improve. Optimize for long-term volume with frequent 90+ minute sessions. The shift you see in the curve was achieved with ~14 hours per week of training. 700 annual hours is a ton compared to the average citizen. It's peanuts compared to an elite cyclist, swimmer or triathlete. Especially, if you adjust for the fact that my work rate is LOW. 5⃣ Eat Real Food - when we are focused on the low end of our curves, our heart rate is down and we can digest anything. There's no need to be pouring sugar into ourselves. Lollapalooza Effects All of the above, working together make the program less stressful on my body. As metabolic fitness improves, we have options: • Do More • Go Faster • Go Longer A year ago, everything made me tired. Today, I still get tired but it's from doing stuff I love: • My Wife's Birthday Swim (9400 LCM) • Mountain Rides • Big Day Training I haven't figured out the return to racing part, but it will come. Metabolic fitness expands our world and makes us feel better in our daily living. Best Part? It doesn't hurt. We simply have to allocate the time. +++ Each of the topics in this post have a section in my Endurance Book. You can access, and subscribe, from my profile. There's 100+ pieces of free content waiting for you.

We have been acquired by Stripe! techcrunch.com/2023/05/31/oka…