Arc Institute

We're grateful to @FoundationOAI for their investment in us and others in the Alzheimer's community. AI will be essential for understanding complex diseases and Arc is working to map the full network of causal factors to pinpoint nodes for intervention: arcinstitute.org/alzheimers-dis…

today we launched bioreason-pro, try using it: app.bioreason.net

Proteins can now talk. Introducing BioReason-Pro, the first reasoning model for protein function. A thread🧵

2026 may be the year AI starts to truly reason about biology. AlphaFold helped close the sequence → structure gap. The next frontier is sequence → functions. Today, together with @genophoria and the team at @arcinstitute , we’re releasing BioReason-Pro — the first multimodal reasoning model for protein function prediction.

BioReason-Pro, the second model in our BioReason series is here! Congratulations @adibvafa, @arman1sa, @Radii2323, and the entire BioReason team!

Learn more about BioReason-Pro from authors @adibvafa, @arman1sa, @Radii2323, @bowang87 @genophoria: arcinstitute.org/news/bioreason…

The model, now on @BioRxiv, was trained on 130K proteins using GPT-5 to generate expert-style reasoning traces. See the preprint: biorxiv.org/content/10.648…

Over 250 million protein sequences are known, but fewer than 0.1% have confirmed functions. Today, @genophoria, @BoWang87 & team introduce BioReason-Pro, a multimodal reasoning model that predicts protein function and explains its reasoning like an expert would.

Want to contribute to similar projects? See our jobs page for open roles (including directors in ML and computational biology, postdoctoral researchers, and scientists in genome editing and functional genomics): arcinstitute.org/jobs

It's been a busy start to 2026 at Arc. We celebrated one year of Evo 2, announced findings from the Jain Lab and Thaiss Lab, and released MULTI-evolve, a new AI framework for designing complex proteins.

Stay tuned for the recording. In the meantime, see the full program and speakers: conferences.ted.com/ted2026

Arc Co-Founder and Executive Director @SKonermann is speaking at TED2026 in Vancouver (April 13-17). She'll be sharing her vision for Arc's Virtual Cell Initiative, recently announced as part of @TheAudaciousPrj' s 2025 cohort, on one of the world's biggest stages.

The Goodarzi Lab is hiring a joint postdoctoral fellow. See Arc open roles: job-boards.greenhouse.io/arcinstitute?g…

In patient cohorts including METABRIC and TCGA, low RBMS3 expression tracks with higher tumor grade, later stage, and worse survival, suggesting that this mechanism holds in human breast cancer as well. See the full paper: science.org/doi/10.1126/sc…

A protein that stabilizes cancer-suppressing mRNAs turns out to be a key brake on breast cancer metastasis. A paper from Core Investigator @genophoria and lab in @ScienceAdvances traces the mechanism to RNA decay and an RNA-binding protein most studies have overlooked.