Brazza Bio

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@BiluHuang Yes, and in addition to the various quasi-scams he's engaged in for decades, you should never trust an "anti-aging researcher" that uses fillers to appear younger.

Feasibility Analysis of Anti-Aging Methods: 21. Resveratrol Tests on mice failed to extend lifespan. Dipak K. Das, an Indian researcher studying resveratrol at the University of Connecticut, published over 150 papers over seven years, mostly demonstrating its positive effects in animal models. In 2012, his papers were found to contain over 145 falsifications. In 2008, pharmaceutical giant GlaxoSmithKline acquired Sirtris for $720 million. This company, founded by Harvard Medical School professor David Sinclair, was developing the anti-aging drug resveratrol. However, in GlaxoSmithKline's clinical trials, resveratrol failed to achieve the expected results, with some patients even experiencing kidney failure. After several years of fruitless research, GlaxoSmithKline disbanded Sirtris, debunking the myth of resveratrol's anti-aging potential. #method-21" target="_blank" rel="nofollow noopener">aging.biluhuang.org/research/criti…

@bananomet @m_goes_distance No, the government only has to take control of the central bank and order it to create money. QE for the people rather than for bankers, for a change!

@BrazzaBio @m_goes_distance The government has to take that money from someone first, you know? Half of the money the gov steals from you gets pocketed by interest groups. It's more effective to simply cancel income tax and lower overall taxation burden.

>be me >read South Korea's birth rate is 0.72 >government paying people $360 to go on blind dates >nobody showed up >Seoul birth rate is literally 0.58 >could you imagine, 0.58 children per woman >the govt used $200b to bribe its citizens to reproduce >citizens said no thank you >I look into it further >Japan is worse >Italy is way worse >I check everywhere >same thing >I am now 3 months deep into civilizational collapse content >I have not reproduced either

@stoked_on_waves The value calculus had improved.

is $FNCH worth looking at now that its $FNCHQ? I remember glancing at this before and thinking the lease boned any plausible liquidation upside

@gtredoux It selects in the sense that if you aren't you get the Jim Watson treatment.

I admire Tony Edwards and find his work useful, but he really has stronger positions than he expresses in public. He is, even at his advanced age (pushing 100) still gun-shy. Academia selects for that. In Fisher's day you said what you thought.

@LocasaleLab We are all peasants differentiated only by income.

Kevin Hall made a big public show including a media tour through CNN and NY Times about resigning from the NIH. He greatly exaggerated and resorted to hyperbole about a purported loss of freedom under HHS. His freedom appears to have been on sale for the price of a pharma compensation package.

@AstralPreobraz1 @AndreasSteno @ChrisO_wiki The US would be great if it had freedom of association.

@AndreasSteno @ChrisO_wiki US model works great not only for the very top but also for the professional class, or upper middle class, whose family incomes are from $130k to $400k per year. They are about 30% of the US population now (they had once been 10%). It is a minority, but a rather large one.

Just to add some nuance to the propaganda here. If you look at the median rather than the mean, which is what actually reflects how most people live, the picture changes quite a bit. Once you also account for unavoidable out of pocket costs like healthcare and education, life in the US looks much more average, and often falls behind Northern European countries for the typical person. The US model clearly creates immense wealth at the very top, but for the vast majority of people, median living standards are what really matter. And by that measure, the story is far less impressive than it is often made out to be.

@Tom_Rowsell You split the "steppe herders", aka the A-word, into two.

Europeans are indigenous to Europe because they descend from four different populations of Hunter-Gatherers, all of which inhabited Europe during the stone age. 1. Western Hunter-Gatherers (WHG) - a genetic profile that emerged in Western Europe 15,000 years ago but which has its roots in Europe's earlier ice age populations, mainly the Epigravettian culture which emerged in South Eastern Europe 21,000 years ago, coming out of earlier Gravettian culture people which formed some 33,000 years ago. 2. Eastern Hunter-Gatherers (EHG) who formed a genetic cluster in Eastern Europe 13,000–15,000 years ago. They descended mainly from Ancient North Eurasians from Siberia who themselves descended from Upper Paleolithic Europeans of 40,000 years ago. 3. Anatolian Hunter Gatherers who learned to farm and began to colonise Europe 8000 years ago mixing with the WHG. 4. Caucasian Hunter Gatherers who first came down from the mountains to mix with EHG in South Russia some 8000 years ago, but did so again in the Eneolithic. With such astonishing continuity and undeniably deep roots, anyone denying our indigenous status is both morally and intellectually bankrupt and should be publicly shamed.

@LocasaleLab I've never heard of a single case of a PhD student living in a dorm, unless you mean living with roommates because they can't afford to rent a place of their own with their stipend.

PhD students now can barely show up, do little to no work, have no interest in their thesis research, take on side jobs or excessive extracurriculars, and still draw a full salary and benefits. They can leave as they choose with a diploma, or be “fired” by being granted a degree. Many stay because they’re effectively being paid to remain living a college student life minus the responsibility of grades and exams — they even go to frat parties, date undergrads and live in dorms as they approach their 30s.

@LocasaleLab Hard to believe that Some do minimal work and still complete a PhD in as little as three years..

It doesn’t stop at the undergraduate level. At the PhD level, standards have eroded as well. Candidacy and defense exams are largely ceremonial. Dismissing students for poor performance is extremely difficult, and in some cases faculty face consequences for trying to enforce standards. Students can quiet quit, continue receiving stipends, and coast until they choose to leave. Some do minimal work and still complete a PhD in as little as three years. Funding agencies such as NIH reinforce this by emphasizing throughput metrics like time to graduation as a condition of funding. The result is a lowering of standards at every stage.

@Noahpinion Wasn't that the plan?

The whole Anglosphere is rotting from the inside out.

@m_goes_distance BPC-157 messes with serotonin neurotransmission. It may cause depression in some people.

>be me >read that sperm counts dropped 50% in 40 years >panic >go down rabbit peptide rabbit holes at 2am >find an elite telegram group with 4.7K members >nobody has a medical degree >everyone has abs >order BPC-157 from a guy named Keith >Keith is based in Poland >Keith ships fast >Keith knows things my doctor doesn't >I am now Keith

@m_goes_distance Why is the biotech startup industry so dependent on venture capitalists? Why can't banks lend to it?

It's genuinely insane how much progress biotech has made in the last 90 days: - Two years ago I watched Lucy Therapeutics shut down after 7 years and $42M from Bill Gates, never reached human trials. Last month DeSci crowdfunded €2.5M in 72 hours for Dr Barbacid cancer trials and went straight to human trials. Zero VCs and zero committees in the middle. And it's not even about the money. The goodwill - Gene therapy cost $2-4M per treatment a year ago because manufacturing was artisanal and nobody was actually solving it. Now automation's dropping costs toward $200. Turns out it was an engineering problem all along. - Just a year ago, the FDA wouldn't touch longevity. In January 2026, first FDA-approved human trial reversing cellular age launched (ER-100). We're testing age reversal in humans right now. Not mice. - Psychedelics stuck in regulatory hell for 50 years. In February 2026, Compass crushed Phase III for psilocybin in treatment-resistant depression. - In 2023, AI drug discovery was hype. $17B got invested, zero approved drugs. Early 2026, Ginkgo x OpenAI ran over 200k autonomous experiments, 36K of those were unique. Protein costs dropped by 40% and they're already shipping commercially. Discovery timelines collapsed. - Just last year, FDA required full GMP pre-Phase 2, moved at 1950s speed. This quarter,we're fast-tracking frontier therapies, relaxing requirements, launching pilots. Something shifted and the regulatory wall is cracking. - In 2024, clinical trials had to run in US at 2x cost, half the speed. Right now in Singapore and China running trials 50% cheaper, 2x faster. Companies routing around FDA entirely. The US model is optional. I could keep going on with these, but you realize that the bottleneck was never the science. It was funding models, regulatory speed, manufacturing, geography etc And most of them are breaking since last October. Biotech has shed 30 years of broken infrastructure in 5 months and I can't be more bullish. bio/acc.

@BrianRoemmele I think in that case it's more about Germany's decision to shut down all nuclear plants and consequent energy crisis...

We have 5000 days until the end of work as we know it. Read more at: ReadMultiplex.com.

@C_S_Skeptic Because academia is completely different. Last authors are notorious for not following this pattern.

THIS is what Musk does, in six bulletproof points.

@runquasimodo @Scarlet_Sash @ClausCarlsen1 We don't ship outside North America because customs have shown a tendency to seize our product. Clearly Europe's borders are stricter for certain things more than for others.

@Scarlet_Sash @ClausCarlsen1 @BrazzaBio Yes 🙌 I’m not sure if they ship to Europe but it’s a developing sweetener to keep an eye on !

One of the cool things about stevia leaf is if you use too much it gets bitter fast

Scientists mass-produced sugar alcohols to replace sugar. While useful, they can cause osmotic diarrhea because they are non-absorbable solutes, leading to phenomena like the sugarless gummy bear challenge. I don't know why humanity does this to itself.

@BrandonLuuMD This is actually very useful, if it really works. Timed light pulses and melatonin intake before a trip can prevent jet lag.

Claude is actually nuts. I've wanted to build a science-based jet lag app for a while. It reviewed the circadian science, temperature minimums, and directional phase shifting, then built a web app that times light exposure and melatonin properly for a specific trip.

Already every value except for money has been destroyed. If the singularity truly were upon us, and money too were to go, what would happen to all those whose life-meaning comes from having "made it"? The singularity would be accompanied by mass suicides; a true apocalypse.

@WavyAVibes @BrianRoemmele Consciousness is a property of all matter. Self-awareness of course requires some recursivity in addition.

@BrazzaBio @BrianRoemmele Intelligence doesn’t need to be self aware concious to be intelligent

A Petri Dish Of HUMAN Brain Cells LEARN TO PLAY THE GAME DOOM! In a groundbreaking fusion of biology and silicon, scientists at Cortical Labs have taught a cluster of lab-grown human neurons to play the iconic video game Doom. Not your typical AI triumph, it’s a petri dish of actual human brain cells, reprogrammed from adult donor skin or blood samples, wired into a $35,000 biological computer called the CL1. Building on their earlier Pong demo, this new feat sees the neurons navigating hellish levels, dodging demons, and even firing shots with surprising efficiency. Programmer Sean Cole pulled it off in just a week using a Python API on GitHub, a stark contrast to the year-plus effort for Pong. Astonishingly, these organic gamers outperform GPT-4 in speed and latency, proving that even a tiny blob of human intelligence can adapt and learn in ways silicon struggles to match. The excitement is palpable: this isn’t just a gimmick; it’s a window into revolutionary medical advancements. Imagine using such bio-computers to model brain diseases, test drugs, or even restore neural functions in patients. With cloud access to CL1 rentals, developers worldwide can experiment, accelerating discoveries that could redefine neuroscience. We’re witnessing the dawn of hybrid intelligence, human biology augmented by tech, evolving beyond our wildest dreams. Yet, amid the thrill, a chill runs down my spine. What are we building here? These neurons aren’t conscious (we hope), but they’re derived from humans and exhibit learning behaviors that echo our own cognition. Echoes of The Matrix or dystopian sci-fi like the “torment nexus” from Doom novels loom large. Could this lead to ethical nightmares—exploiting bio-intelligence for warfare simulations, or worse, creating sentient systems trapped in digital hells? And the philosophical rabbit hole deepens: Is life merely nested Russian dolls (matryoshka, if you prefer) of biological smarts? We, as evolved intelligences, are now crafting our own mini-brains, layering complexity upon complexity. Are we “gods” in the making, or just the next doll in an infinite regress, destined to birth something that surpasses—and perhaps supplants, us? This experiment, detailed in HotHardware’s coverage, pushes boundaries we might not be ready to cross. It’s exhilarating proof of human ingenuity, but let’s proceed with caution lest we summon demons we can’t control and we wind up in the Petri dish?