Jinmiao Chen Lab

Very excited to share our recent paper titled 'Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes' published in @GenomeMedicine genomemedicine.biomedcentral.com/articles/10.11…

Happy to announce that our Nature Methods paper 'SpatialGlue' was recently featured in A*STAR Research: research.a-star.edu.sg/articles/highl…

We would like to announce that disco has moved to disco.bii.a-star.edu.sg. Thank you for your support ☺️

Congratulations to Azimuth 2. Delighted that Disco is contributing to this initiative 😊

Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)

Congratulations and very nice study @DGateLab 🙂

Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passive and actively immunized #Alzheimer’s disease patients @NUFeinbergMed nature.com/articles/s4159…

@RongFan8 @LongYahui Happy new year Dr Fan ☺️😋😇

@CJM_lab @LongYahui 😋😋😋 happy new year 🎊🎆

Lab Gathering Lunch and Chinese New Year celebration 🎉🎉🥳 Also all the best to @LongYahui and chengwei as they embark on their new journeys 😊

🎉 Congrats to the Singapore research team on ezSingleCell! 🎉 A game-changer for #singlecell & #spatialbiology, it simplifies data analysis from platforms like Chromium, Visium & Xenium without programming expertise! 🚀 Learn more: nature.com/articles/s4146…

🚀 DISCO December Update 🚀 📊 8,529,538 cells from 1,345 samples across 94 projects added in this month's update! 🎉 Dive in and explore the data that matters to you! 🧬 Check it out here: immunesinglecell.org #Bioinformatics #SingleCell #LLM #DISCO

🎉 Excited to share that our paper DISCO: a database of Deeply Integrated human Single-Cell Omics data has reached 100 citations! 🚀 Grateful for all the researchers utilizing and building upon DISCO. Here's to advancing single-cell biology together! 💡📊 #SingleCell #Bioinformatics scholar.google.com/citations?view…

@FEBSnews @FEBS_JS @FEBSOpenBio @FEBSJournal Our keynote of Career Day is a FEBS-powered breakout lecture by Dr. Jinmiao Chen (@CJM_lab)! 🌟 She introduces the fundamentals of spatial omics and shares her lab's cutting-edge AI-driven analysis method, STAMP (Zhong et al., 2024). 🚀

🚀 scEnrichment Update! The scEnrichment tool now features an updated reference geneset with 524 cell type 🧬 and phenotype 🔬-related genesets! 🎯 Input your geneset to uncover enriched phenotypes or cell types with ease. 🔗 Try it here immunesinglecell.org/tool/sc_enrich… #scRNAseq #Bioinformatics #Genomics 🧑‍🔬✨

Rediscovering publicly available single-cell data with the DISCO platform academic.oup.com/nar/article/do…

🚀 Exciting update! DISCO now supports batch downloads—access data from 113,277,088 cells across 18,402 samples with ease. Perfect for training your LLMs or fueling other applications! 🌐📊 #SingleCellData #Bioinformatics #AI @LLM immunesinglecell.org/download

Our data showed varied functions of myeloid cells in early life while identifying therapeutic targets. We are grateful to our collaborators @FGinhoux @HongyanWang9 @lai9uan @CJM_lab @Abhay_R_ and their teams for all their support, ideas, tools, and enthusiasm over the years!

Exiting new method, looking forward to trying it!

Congratulations to our bioinformatics collaborator @CJM_lab for yet another excellent method to decipher the #spatialtranscriptomics data. I look forward to the future of deeper understanding of #tumourmicroenvironment with our powerful partner!