

Yuseff Lab
177 posts

@LabYuseff
Where B Cell Biology meets Immunology 💥









We have written a spotlight on this fantastic paper as well @mattilalab @labyuseff @srishti_mandal check it out: rupress.org/jcb/article/22…

.@LabYuseff @uc_chile show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation hubs.la/Q03y2G-f0
















B cells form SNX5-rich protrusions at the plasma membrane which dissipate upon interaction with soluble antigens. SNX5 accumulates at the immune synapse regulating actin-dependent spreading responses. SNX5 regulates endo-lysosomal trafficking required to promote antigen extraction and presentation. @LabYuseff life-science-alliance.org/content/8/1/e2…











