Dr. Scott Wallace 🚨

Demis Hassabis just described the moment medicine stops treating disease and starts deleting it from the source code. For all of human history, doctors have fought symptoms. The tumor. The organ failure. The collapse. Always downstream. Always after the damage has already started. The cause sits upstream. Written into the DNA. Ninety-eight percent of the human genome sits in non-coding regions. For decades, science understood the genes but couldn’t read the vast dark territory between them. That’s where most disease hides. Hassabis: “It takes the big, long genetic sequences and then it tries to predict, if you made a mutation to this particular single letter, single position in the genetic sequence, will that be a harmful mutation that might cause disease, or is it benign?” AlphaGenome reads your entire genetic sequence and identifies the exact letter that’s corrupted. Not a region. Not a probability range. A single position in a three-billion-letter sequence. That alone would be a generational breakthrough. But most diseases aren’t that clean. Hassabis: “What if they’re multigenic diseases where there’s cascades of mutations causing the problem? Those are even harder to detect, but actually perfect for sort of AI.” One mutation is hard enough to find. A cascade of mutations interacting across the genome is a problem no human researcher can hold in their head at once. Three billion data points. Compounding errors across all of them. The human brain cannot solve that. AI doesn’t solve it either. It maps it. All of it. At once. The most devastating diseases on Earth. The ones medicine has called untreatable for generations. They are not mysteries to the algorithm. They’re compute problems. But finding the error was only ever half the equation. You also need the ability to fix it. That tool already exists. CRISPR is a molecular scalpel. It cuts DNA at exact positions. The limitation was never the editing. It was knowing exactly where to cut. Hassabis: “A kind of combination of things like AlphaGenome and CRISPR could be incredibly powerful.” AI reads the code. CRISPR rewrites it. One finds the mutation. The other corrects it at the source. Not managing symptoms. Not slowing progression. Deleting the error from the genome. The implications go beyond treatment. A disease corrected at the genetic level doesn’t just disappear from one patient. It disappears from their bloodline. The read access is here. The write access exists. The merge is inevitable. The era of accepting a broken genetic hand is ending. We stopped being passengers in our own biology.

Today, The Intercept reported that the federal government is ordering Reddit to appear before a grand jury in connection with the anonymous speech of a user who criticized the Trump administration's deportation efforts. Immigration and Customs Enforcement tried to identify a user based in the Pacific Northwest without success. They approached Reddit, demanding identifying information on the user and refusing to specify the posts that caught ICE’s attention. Reddit has not identified the user. Reddit’s own attorneys reviewed the user’s posts for any speech not protected by the First Amendment, and found none. Government critics are not suspects and free speech is not a crime. The First Amendment protects our right to criticize the government anonymously — an American tradition that dates back to the founding. So far, the government hasn’t been able to point to a single Reddit post that’s not protected by the First Amendment. Not one. By putting the administration’s feelings above the First Amendment, government agents are sending a deliberate message to each of us: Don’t criticize us — or else. How we respond to this chilling moment matters. Today, lawmakers from both parties are busy promoting age-verification laws that would force each of us to reveal our identity before we speak online. If lawmakers had their way, the Reddit user would already be standing in court just for expressing his or her beliefs. Who knows how many of us would be hauled up next?

according to court document, Mike Missanelli was arraigned this morning on simple assault and harassment charges:

If Trump announces a peace deal with Iran, the same people who tell you he’s going to nuke Iran are going to immediately switch their argument to the peace deal isn’t good enough.