Dr. Joseph Barsuglia

You’re hearing a lot about ibogaine lately. But ibogaine is just 1 of 30+ alkaloids in iboga. Nature doesn’t work through isolated fragments. The full plant matrix has guided healing for millennia—and will outlast single-molecule medicine. 🌿

We already had legal psilocybin in 1958. Sandoz Laboratories, the same company that invented LSD, sold pharmaceutical psilocybin legally throughout the 1960s. It even had a brand name: 𝘐𝘯𝘥𝘰𝘤𝘺𝘣𝘪𝘯 Doctors prescribed it openly for: depression, anxiety & alcoholism. 2mg pills. Sold all over the world. Zero reports of serious complications. 𝗘𝘃𝗲𝗿. It was removed from the market in 1965, not because of safety data, but because of politics. Now we're calling it a breakthrough drug. Same pills. Just 60 years later.

@RCarhartHarris Can’t wait to see the difference in the magnitude as a distinct predictor of therapeutic response compared to mystical-type experience, given the longstanding association and findings with MEQ, 5D-ASC, etc.

Off all the constructs/phenomena that predict therapeutic response with psychedelic therapy, the best is emotional breakthrough (EB). It's not "oceanic boundlessness", it's not "mystical-type experiences," it's EB. Expect more on this soon...

@PaulAustin3w I believe once COMP360 is approved, DEA is not compelled remove all psilocybin from Schedule I. FDA approval is product-specific, not substance-wide. Other psilocybin forms (natural) likely remain Schedule I. Reference Sativex/Cannabis. Illogical scheduling in the first place.

If synthetic psilocybin (aka COMP360) is approved for TRD by the end of 2026, most headlines will focus on clinics, psychiatrists, and stock prices. But this misses the most critical element, IMO. Approval wouldn’t just validate synthetic psilocybin as a treatment but, more importantly, force a rescheduling conversation at the executive level. Once the FDA approves psilocybin for TRD, the DEA is legally compelled to move it off Schedule I. That single step not only reboots U.S. drug policy bbut also: - Increases state autonomy - Collapses research costs - Loosens banking restrictions - Categories of work previously “underground” or legally ambiguous will surface Here’s why this matters if you’re considering investing or working in the psychedelic space: • Demand will outpace access. Even if COMP360 is approved, it’s far from guaranteed that insurance will cover six-hour psychedelic sessions at scale. Approval without accessibility will continue driving people outside traditional medical systems in search of preparation, integration, and ongoing support. • The work won’t end at symptom relief. Psilocybin opens a critical learning window. What happens in the 2–3 weeks after the experience — lifestyle changes, relational shifts, nervous system regulation, metabolic health — will largely determine whether outcomes last. Most medical practitioners are not trained in the overlap of physiological well-being and mental health. This is a HUGE gap. • New roles will emerge fast. Education, integration, coaching, facilitation, research, and community-based support aren’t “adjacent” to the clinical model, they’re essential complements to it. The ecosystem will need people who can bridge physiology, psychology, and lived context, not just administer a protocol. • This is bigger than individual healing. Psychedelics reorganize how people relate to their lives, their bodies, and one another. If we lose that relational and systemic lens, we’ll miss the real promise of this moment. COMP360 approval would be a medical milestone, one nearly 50 years in the making. But for those REALLY paying attention, it’s also a career signal. A signal that the next phase of this work will be built not only in clinics, but in the spaces that help people turn insight into lasting change.

Check out my latest article: Is Your “Clean” Nicotine Hardening Your Arteries? What the Vascular Data Actually Show linkedin.com/pulse/your-cle… via @LinkedIn

Science just did the unthinkable: Researchers genetically modified the world's deadliest virus to trace how psilocybin physically repairs the brain... 𝗱𝗼𝘄𝗻 𝘁𝗼 𝘁𝗵𝗲 𝙚𝙭𝙖𝙘𝙩 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻𝘃𝗼𝗹𝘃𝗲𝗱. We've finally figured out why one trip can change your entire life 🧵

I never expected watching 3 grandmas take mushrooms for the first time… would be this beautiful. Now I just wish my mom would watch this video.

This may be partially why psychedelic therapy demonstrates transdiagnostic efficacy.

That's the truth, in simplest terms.

Honored to be interviewed here by @abbierosner Rosner, who has a unique focus on psychedelics, aging, and elderhood. In Sickness and in Health – Ibogaine’s Promise for the Aging Brain open.substack.com/pub/abbierosne…

@Psyched_Alpha Wise and strategic pick!

Matt Zorn, the Government’s Former Adversary, Is Now Its Psychedelics Czar Matt Zorn made his name suing federal agencies over cannabis and psychedelics policy. Now, he’s inside the system as Deputy General Counsel at HHS, with a psychedelics mandate. psychedelicalpha.com/news/matt-zorn…

@LauraLoomer @RobertKennedyJr Why would you assume that Matt Zorn called himself that. A news article did. If you are going to be the troll queen at least dont make 1000 assumptions

Matt Zorn has been selected by @RobertKennedyJr to be his Deputy General Counsel at HHS. Zorn is telling drug websites dedicated to mainstreaming psychedelics that he is President Trump’s “psychedelic czar”. This appears to have been leaked to the press by Zorn without authorization. He even made up a fake title for himself. Highly doubt the admin would approve of Zorn calling himself “Psychedelics Czar”. Zorn is listed in the public Health and Human Services Directory as “Deputy General Counsel”. I guess he will get along with our new shroom eating Surgeon General who isn’t even a licensed doctor. psychedelicalpha.com/news/matt-zorn…

@danaparish @weldeiry FOXO4 works biorxiv.org/content/10.110…

WOW. Concerning new paper by @weldeiry & Zhang finds Covid's spike protein may worsen cancer by disrupting p53 (a tumor suppressor) & its regulator MDM2, impairing anti-cancer gene activation. This increases cancer cell survival against chemo & may hinder DNA repair. We need spike-clearance/ antiviral strategies to preserve p53’s role! "...important..not only in the context of viral infection and mRNA vaccines...but also for patients with cancer who may be receiving cytotoxic or other cancer treatments."

BREAKING: The FDA has announced that pharmaceutical company representatives will no longer be permitted to serve on its advisory committees.

“In this review, we consider 24 studies, which included 705 individuals receiving ibogaine or noribogaine. This review includes two randomized, double-blind, controlled clinical trials, one double-blind controlled clinical trial, 17 open-label studies or case series (including observational or retrospective studies), three case reports, and one retrospective survey.” sciencedirect.com/science/articl…

@DanWhipple_ @RobertKennedyJr @shellenberger We don’t have a lot of knowledge of the ibogaine treatment although we have heard good anecdotal reports. Any links are appreciated!

I am the recovery first candidate for Mayor of Seattle 2025. The current model of addiction treatment in Seattle is broken. We can dramatically improve, how and where we offer addiction treatment, and save the city in the process. @RobertKennedyJr @shellenberger

@AutismCapital Thousands of Veterans have been treated with ibogaine for PTSD in Mexico. There are multiple papers in the NIH / Pubmed documenting the efficacy of this protocol for PTSD pubmed.ncbi.nlm.nih.gov/38182784/ pubmed.ncbi.nlm.nih.gov/37734158/ pubmed.ncbi.nlm.nih.gov/38377244/ pubmed.ncbi.nlm.nih.gov/32704581/

In the newest Joe Rogan he speaks with Rick Perry and a guy named Bryan Hubbard about the horrible PTSD that vets go through when they come back and the role of psychs like Ibogaine in healing trauma and opiate addictions. Does anyone know of cases where this has worked?

@teslaownersSV @elonmusk To “preserve the light of consciousness” you would need InnerSpaceX. It’s the other direction.

“My plan is to use the money to get humanity to Mars and preserve the light of consciousness.” Elon Musk