
57.5% of patients with treatment-resistant depression hit full remission after a single day of treatment. The placebo group? 0%. JAMA Psychiatry just published these results from a randomized, placebo-controlled trial of synthetic 5-MeO-DMT. This trial didn't include any psychotherapy whatsoever. Without a container for preparation or integration, participants were administered the molecule under clinical supervision. (That’s all.) Patients received up to three escalating doses in a single sitting, only moving to the next one if they tolerated the last and hadn't yet reached a full psychoactive response. The entire experience lasted under an hour per patient. But the clinical benefits extended for months. At 6 months, 87% of initial remitters maintained remission with periodic re-dosing roughly every 6 weeks. This research presents something beyond myopic recommendations for either a daily pill or a single miracle session. These patients got something closer to a periodic and gradual reset. If you or someone you know has been through multiple antidepressants that didn't work… What would you actually want to know before trying something like this? The new study: jamanetwork.com/journals/jamap…









