Steven ten Holder

I think most people should consider becoming scientists. While there is a real risk AI will eliminate jobs, conversely the need for models to understand the world around us through more and better data will increase exponentially. AlphaFold, for example, would not have been possible if not for the work of thousands of grad students and postdocs painstakingly depositing well-curated datasets over decades of meticulous experimental work. We still only understand a fraction of the physical world and beyond, and we’ll only be able to do so if we collect more data and put it into context. Maybe this is a bit naive or utopian thinking, but humans are not designed to look through pages of receipts, read 100-page legal documents, or write reports and POCs no one will ever read. They are wired to explore, driven by curiosity, and have an innate desire to understand the world. Many who are bored or feel a lack of purpose -- with the overhanging (and maybe exaggerated) doom and gloom of AI replacement -- should think about this.

Extremely excited to announce LigandForge 🧬⚡ Generate high-quality peptides at over 10,000x - 1M the speed of state-of-the-art methods like Bindcraft and Boltzgen. Predict binding affinity with 83% correlation to experimental binding data. 150 protein targets benchmarked.

What’s a book you think everyone should read at least once in their lifetime?

claude is independently connected to a plate reader and writing a PyLabRobot interface to it

compbio is about to die. A popular general-purpose AI assistant is already able to write a whole analysis pipeline starting from a simple prompt and a link to the data. Surely, I can do it 10 times faster and using 10 times fewer lines of code, but still “if it works, it works”