Jake P. Taylor-King

My limited experience of blogging has revealed to me that I get more views when: (1) I have short titles; and (2) I'm being negative. I want to do more of (1) and less of (2), so been revamping a few of my posts at wildtypehuman.substack.com

🤝 We were honoured to host Dr Jake P. Taylor-King (@wildtypehuman; pictured), co-founder of London biotech firm Relation (📰 relationrx.com/news/gsk-puts-…) to discuss how Relation model their market analysis and product development. /more

Anyone who’s into the future of the UK should read Sam Kris’ latest piece open.substack.com/pub/samkriss/p…

"A teacher with one standard deviation higher mean grade inflation reduces the present discounted value of lifetime earnings of their students by $213,872 per year of teaching." econweb.umd.edu/~pope/Grade_In…

We should give MPs large caseworker teams (like 25 people each) who can be professional social workers for them and stop the MP themselves having to do it. It’s one of the only things I can imagine that would be popular *and* make it less bad to be an MP.

NHS hospital: I noticed the clock on the wall showed the wrong time. A nurse told me they knew, but they wouldn’t report it because replacing the battery through the NHS would cost £70. A £2 battery... £70. How? Why? That's when I began to dig further. 🧵

They will tell you that anyway Evo2 results are amazing. They always did so. Even if their model is inferior to the GC-content calculation

This is art

@DKThomp But we don’t use LLMs to discover new drugs. We use different models and different, highly proprietary training sets. LLMs are language models. Why would you expect them to be able to discover novel disease targets?

Students & parents should know the facts before they take out the debt. But the truth about graduate earnings has been hidden for years. Government has records tracking graduate earnings, but they refuse to publish them in full. It's time for the truth. Release the records.

Ending Europe's stagnation might be the most important thing in the world right now. Capitalism and liberal democracy have their deepest roots in Europe, but its economic sclerosis is making it irrelevant. • Five US companies spend more on R&D annually than the entire public sector of every European country combined. • Europe's AI sector is worth less than one hundredth of America's. • It is five times more expensive to fire someone in Germany or France than in America. Staff turnover in the US is ten times higher than it is in Germany. • There is no shortage of European entrepreneurs – the problem is that many of them are moving away to set up their businesses. One in ten US startups has a European co-founder. • EU countries shut down 80 gigawatts' worth of coal-fired power plants during the 2010s, with most of the shortfall being made up by expensive, unreliable wind and solar power. • The EU charges about six times more per ton of carbon than China does, and about 50 percent more than California. Most US states don't price carbon emissions at all. On the Works in Progress Podcast, I sat down with @pietergaricano and @Aria_Babu to talk about what's gone wrong and what Europeans can do to return to the growth and dynamism that once made Europe the world's preeminent civilization. Listen now! Spotify: open.spotify.com/episode/1rKwPY… Apple: podcasts.apple.com/gb/podcast/why… Youtube: youtube.com/watch?v=_JGhRC… Substck: worksinprogress.news/p/why-europe-h…

It's a sign of a diseased mind to read this story and try to put a negative spin on it. Not every single thing your enemies do has to be bad. They're not demons.

@webdevMason Much anti-aging research seems to come down to damping down the innate immune system. Live longer but influenza cripples you. It will be interesting to see where the tradeoff is here…? Maybe you don’t form an adaptive response properly?

I would LOVE to rid my family of both minor and serious infectious illness, but if the immune system already has a "just do what you do, but better" mode, the obvious question is why it hasn't been adaptive for that to be constantly activated by default

Sam Kris one-shots SF...

@Fremond_ Love a Sam Kris take down, the Kamala one is unparalleled samkriss.substack.com/p/i-told-you-so

This has genuinely been a fantastic read

Private Eye acknowledges the genius of our political commentariat.

Ed Miliband’s lack of basic understanding of energy taxation and economics was on full display here. And these numpties are in the government. It’s hardly a surprise that the country is in a total mess.

Isomorphic must be in a crazy bind right now. Given the hype about their models/frontier capabilities, I can't see how they could reveal their actual pipeline without it being a huge let down. Heading towards: "solved biomolecular design and all I got was a me-too TL1A mAb"

@rsasaki0109 It might just as well the agent writes the paper, makes rebuttals, polishes and makes final submission. Then the agent books air tickets and attends the conference and writes reports. The human author did nothing except paying for electricity bills

@teortaxesTex This is my big worry: low pay and substandard colleagues, why would anyone competant want to move into politics? But it's actually *the* most important thing that could happen right now in the UK.

Am I wrong or have none of these people had any experience in governance? Lawyers, investment bankers, think tankers, officials. Not one was, like, a mayor. I get that UK is not China, but is that their normal practice?

Or in other words: «the three last prime ministers of the Yookay all plunge to -50% net satisfaction, it just may take 16, 11 or 2 months» I think it's not about Sir Keir. The entire regime is losing legitimacy.

@owl_posting @HighResBio Expensive, but they're probably the market leader...!

@wildtypehuman @HighResBio no reason in particular, they just hadnt come up in my conversations!

Heuristics for lab robotics, and where its future may go (8.4k words, 38 minutes reading time) owlposting.com/p/heuristics-f… this is the longest article i have ever written. in it, i discuss the three ideologies of lab robotics progress, why they may all converge on the same business model, whether any of it will be actually helpful for the problems that plague drug discovery the most, and more this article involved discussions with sixteen people over the course of three weeks, and i am very grateful to them for answering the many questions i had about a field that i had long considered alien finally: this is a complicated field that is really still being birthed, so please let me know if i got anything wrong