Buck

741 posts

Buck

Buck

@2024Buckeye

Minnesota, USA Katılım Temmuz 2024
234 Takip Edilen26 Takipçiler
amit kumar
amit kumar@kumar_amit·
@underIineoasl Yes. Use brave browser... a lot of the times you just won’t see any ads and you can play picture in picture on the iPhone
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🌍
🌍@underIineoasl·
anyone noticed certain YouTube videos you can close the app and they continue to play even without premium
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Zee 🔥
Zee 🔥@Zeeeee_xx·
@MyronGainesX Abort and preach 😂😂😂😂 That’s way funnier than anus and reach
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Myron Gaines
Myron Gaines@MyronGainesX·
Imagine talking shit for 5 years about accountability and getting 2 girls pregnant? Abort N Preach are about to get COOKED! 👨🏾‍🍳🔥🍳🔥 It's TIME BOYZ! RIP Anus N Reach!
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verbinnen.eth💈
verbinnen.eth💈@VerbinnenAndrew·
We disrupted a $4 billion company with an AI chatbot and a thousand dollars. Here's how we did it. Veradermics ($MANE) raised $256M and trades at a ~$3.8B market cap on the premise of extended-release oral minoxidil. The idea makes sense. Oral minoxidil works, but standard oral minoxidil releases fast. You take the pill, the drug spikes quickly, and that spike is where a lot of the side effect concern comes from (heart rate, blood pressure, fluid retention, etc.). So the question is whether you can give patients more minoxidil but release it more slowly, getting stronger hair growth without the same side effect burden. That is what Veradermics is trying to prove with VDPHL01. The data so far is genuinely impressive. In Study 302, Veradermics tested 8.5mg once daily and 8.5mg twice daily in men with pattern hair loss. After 6 months: placebo gained +7.3 non-vellus hairs/cm², 8.5mg once daily gained +30.3, and 8.5mg twice daily gained +33.0. They also reported no treatment-related serious adverse events, no cardiac adverse events of special interest, and overall side effect rates similar to placebo. For context, finasteride 1mg has been reported around +12 to +16 hairs/cm² versus placebo. So yes, VDPHL01 looks very real. But here's what struck us. Minoxidil itself is not a new molecule. It is a well-understood drug, used for decades. Low-dose oral minoxidil is already commonly prescribed off-label for hair loss today. Veradermics is taking the traditional biotech route: large trials, FDA approval, patents, years of development, and eventually what will likely be premium drug pricing. That model can make sense, but we started asking a different question: if the active ingredient is already familiar, could we build a practical extended-release oral minoxidil option for patients sooner? Not Veradermics' drug. Not their gel matrix. Not their clinical dataset. But the same basic concept. So we started digging. We used ChatGPT over a couple of days to review the existing formulation literature and patent landscape, and landed on a different approach: a lipid matrix. Lipid matrices are commonly used in drug formulation to slow the release of active ingredients, but to our knowledge nobody had applied this approach to oral minoxidil for hair loss. We put together the formulation instructions and sent them to our compounding pharmacy. Our pharmacist made the tablets and shipped them back. Then we ran dissolution testing to see how they released compared to standard immediate-release oral minoxidil. The product we tested was MINX: a 5mg once-daily oral minoxidil tablet designed to release more gradually than a standard immediate-release tablet. The data surprised us. Standard oral minoxidil released almost the full dose in under 10 minutes. MINX released gradually over approximately 12 to 14 hours. We tested it in two environments. pH 1.2, which mimics the stomach, and pH 6.8, which mimics the small intestine. We got the same gradual release curve in both. Same drug, totally different release profile. To be very clear: this is dissolution data in beakers. It is not human clinical data. It does not prove better hair growth. It does not prove fewer side effects. And MINX has not gone through anything resembling Veradermics' clinical program. That is exactly why we are starting at 5mg, not 8.5mg twice daily. If the tablet ever released faster than intended, 5mg is still within the range already commonly used off-label for hair loss. The goal is not to overstate what we have. It's to build useful, patient-centered products faster. MINX exists because we think the drug development landscape is changing. A small team with scientific curiosity, AI tools, compounding and telehealth infrastructure, and fast lab validation can now move in weeks on ideas that used to take years just to begin testing. Veradermics deserves credit for pushing extended-release oral minoxidil into the mainstream. But patients should not have to wait years and pay premium pricing to access every practical improvement around a drug that clinicians already understand. MINX launches May 11th on Anagen. If you made it this far, drop a comment and I'll DM you the waitlist link.
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Patrick B
Patrick B@PatrickNSL_·
@DovySimuMMA Prates is so smart. Has a daughter in Australia more than 40 hours from Brazil. Dude is playing chess
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Dovy🔌
Dovy🔌@DovySimuMMA·
Carlos Prates daughter and mother watching him from cageside
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NRM84
NRM84@Mappy6984·
He sure does have a nice car with all his fraud money
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Buck
Buck@2024Buckeye·
@CheekyChic504 @LASHYBILLS It’s true. People think they being laced but that’s not true. It’s paranoia and psychosis from weed. That’s it.
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Theresa
Theresa@CheekyChic504·
@LASHYBILLS You not the only 1 I’m dealing with my son at this moment as I’m looking at this video. The doctor said new strains of weed have a lot of young boys doing exactly the same. It’s making them go into psychosis and schizophrenia. That shit was scary.
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LASHY BILLS
LASHY BILLS@LASHYBILLS·
A man shares his testimony after being laced while smoking with his friends and how God saved him.
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Buck retweetledi
Fight Back Podcast
Fight Back Podcast@ShieldsClips·
Our podcast just hacked the home camera of Andrew Wilson and this is crazy
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Buck
Buck@2024Buckeye·
@AntiMushy @andrsnoms @dailysneako So you’re uneducated because you don’t know English fully? Maybe this is why the Chinese make more money and more successful in your own country. Sad.
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Daily SNEAKO
Daily SNEAKO@dailysneako·
A fan in Malaysia just invited SNEAKO to his PRIVATE island 😳💀 “Really really private... one island with 10 jet skis. I’ll pay for everything. There are a lot of things you haven’t seen in Malaysia yet... I’ll show you.”
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Buck
Buck@2024Buckeye·
@schober222 Where can we buy it from, do u have a discount code and how do we know the product is pure and legit??
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ᴊ0ʜɴɴʏ
ᴊ0ʜɴɴʏ@jt0hny·
this creature has 22 different men to choose from… hoeflation is out of control
ᴊ0ʜɴɴʏ tweet mediaᴊ0ʜɴɴʏ tweet media
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Crypto Tea
Crypto Tea@Cryptotea·
Clavicular looksmaxxing Gorlock
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Rain Drops Media
Rain Drops Media@Raindropsmedia1·
Noah Lyles faces criticism for his reaction to seeing his bride Junelle Lyles’ dress & look. 👀👗
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Barragers
Barragers@barragers·
Clavicular announces 500 girl modeling competition where the winner gets pregnant by him
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܁
܁@drearyfying·
@bryan_m_b_u_3_m @barragers it’s reversible in most cases. 95% with basic medicine (like the HCG he mentionned), and 99% by all means
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Buck
Buck@2024Buckeye·
@BowTiedWaddle I hope you get in bro. Don’t give up. We can do it ❤️
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Penguin
Penguin@BowTiedWaddle·
Well I didn’t get into med school this cycle. Waitlisted, but odds of getting off are low. Not the outcome I wanted, but God’s never taken me down the wrong path before. No sense wasting time hum glum when He’s got my back. That being said, I’m not too sure what my next steps are. I know I’m going to re-apply, but I’m back on the job market. Shot in the dark, but if anyone in the healthcare/bio space is hiring, here’s a brief resume: - 6 years of experience in the ER - Masters in Biomedical Sciences - Research that is pending publication - strong desire to bring healthcare back to where it belongs - between patients and physicians - doing what I can to stay up to date with AI Can send a CV if anyone’s interested. While I don’t know where to go from here, I know God’s got me and I’m excited to see where he takes me
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Comtagain
Comtagain@comtagain·
Brazil with only white people would be the Garden of Eden
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Anderson
Anderson@andrsnoms·
@dailysneako There are a lot of things I haven’t seen in Malaysia even though I’m Malaysian. INVITE ME
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