3Brain AG

One Platform. 96 Wells of Possibility. In our last post, we saw how the HyperCAM Delta enables scalable, high‑resolution electrophysiology to today’s most complex in vitro models, but do you know about the plates which make simultaneous recording from every well and every electrode possible? Meet the CorePlate™ Multi-well series. With the world’s first 96‑well HD‑MEA - CorePlate™ 96W, and CorePlate™ 24W, the HyperCAM Delta supports seamless progression from focused functional studies to high‑throughput screening and drug discovery all on a single platform. Interested to know more about these plates? Send us a message: 3brain.com/contact?utm_so… Stay tuned, next up, a closer look at the cell models and applications driving this platform.

The Advances in Cell‑based Screening in Drug Discovery 2026 conference @ELRIG_SCIENCE is just around the corner, visit us at booth #4 to see how CorePlate™ can support your journey toward human‑relevant drug discovery. As the industry moves toward more predictive, cell‑based screening paradigms, functional data is becoming a critical decision‑making tool. Whether you are working with iPSC‑derived neuronal or cardiac models, complex 3D spheroids, or brain organoids, 3Brain’s CorePlate™ enabled multi‑well HD‑MEA technology delivers scalable, high‑resolution electrophysiology supporting both focused mechanistic studies and high‑throughput screening workflows. Visit our poster with Axol Bioscience “Electrophysiological Analysis of axoCells™ Atrial and Ventricular Cardiomyocytes With CorePlate™ Enabled HD-MEA" presented by Sercan Deniz @DenizPhd to learn how we’re helping bridge the gap between complex in vitro biology and robust functional insights. See you in Gothenburg! #3Brain #ELRIG #Electrophysiology #CellBasedScreening #DrugDiscovery #HDMEA #iPSC #3DBiology

One Platform. 96 Wells of Possibility. The HyperCAM Delta was engineered for high-throughput, high-precision functional screening of neuronal and cardiac cells. By capturing functional activity simultaneously across 24,576 electrodes, it eliminates the trade-off between detail and speed. Researchers can now maintain high-resolution insights while accelerating toward large-scale discovery. Keep an eye out for what’s coming next: a closer look at the plates that make this possible. Find out more on our website: 3brain.com/products/multi…

Translating Technology: Human Brain Slices as a New Screening Platform Testing neuromodulation technologies such as magnetoelectric nanoparticles (MENPs) in relevant models can be a challenge. Although various in vitro and ex vivo platforms such as cell cultures, rodent brain slices, and organoids offer alternatives for screening neural implants before in vivo studies, each still falls short of reproducing the full structural and functional complexity of human brain tissue. New research by Eggert et al., published in the Journal of Neural Engineering, is helping advance this field by establishing organotypic human brain slice cultures as a screening platform for neuromodulation techniques. Using CorePlate™, the team demonstrated spiking and field‑potential activity is present in fresh human brain slices treated with MENPs. Offering a high‑resolution, human‑relevant method which can help develop ideas from engineering concepts to clinical applications, providing an ethically preferable and early‑stage alternative to animal models for evaluating emerging neurotechnologies. Huge thanks to Franz A M Eggert, Berkhan Genc, Sena Nur Arduc, Anouk Wolters, Kim Rijkers, Kristen Kozielski, Yasin Temel and Ali Jahanshahi at Maastricht University Medical Center (MUMC+). Check out the paper here: iopscience.iop.org/article/10.108… #3Brain #HDMEA #electrophysiology #HumanBrain

The 10th annual Stanford Drug Discovery Symposium (SDDS 2026) starts soon! Come and meet the 3Brain team as we connect with the brightest minds in pharma, biotech, and academia to discuss how we can help you investigate in vitro neuronal and cardiac function. In the race to bring life-saving therapies to market, the quality of your functional data is everything. Whether you are screening compounds on iPSC-derived networks or complex 3D organoids, 3Brain provides CorePlate™ enabled HD-MEA technology in formats up to 96 well that delivers the high-throughput, high-resolution insights needed to advance your drug discovery needs. Stop by and meet Amber Jolly to find out how we are bridging the gap between advanced biological models and functional insights. See you at Stanford! #3Brain #SDDS2026 #DrugDiscovery #StanfordMedicine #HDMEA #BioTech #HighThroughputScreening

We are thrilled to be a sponsor of the upcoming NEURONUS IBRO-PERC Neuroscience Forum in the beautiful city of Kraków! As one of the premier neuroscience events in Central Europe, Neuronus is the perfect place to discuss investigating neuronal function. We’ll be showing how our CorePlate™ HD-MEA platforms, from single to 96-well bridge the gap between complex biological models and functional insights. Come and Elisa Monz & Albert Steiner at booth G4 to find out how 3Brain’s HD-MEA can help advance your electrophysiology workflow. #3Brain #Neuronus #Neuroscience #HDMEA #Electrophysiology

Mapping the Hidden Mosaic While the vertebrate retina is typically organized into distinct layers, displaced retinal ganglion cells (dRGCs) are different in that their cell bodies lay within the inner nuclear layer rather than the ganglion cell layer. The question as to the true role of these dRGCs, and if they are integrated members of the visual circuit has been a question in retinal neurobiology for quite some time. New research by Sabrina Duda et al., alongside Christian Puller & Martin Greschner published in Scientific Reports, is improving our knowledge of dRGCs by mapping the spatial distribution, function, and receptive fields of these unique cells, and finding out how they fit into the sustained ON alpha (sONɑ) RGC mosaic. Utilizing CorePlate™ enabled HD-MEAs with 4,096 simultaneously recording electrodes, the group was able to capture the electrical fingerprints of dRGCs alongside their regularly placed counterparts. By correlating their light-evoked responses, they demonstrated that displaced sONɑ RGC receptive fields fit into the gaps of the regular cell mosaic and serve the same functional role as others within the mosaic. This research reveals that cell body position can be surprisingly flexible and shows that even "displaced" neurons are essential components of the brain's complex sensory circuits. Huge thanks to Sabrina Duda, Martin Greschner, and the team for their contribution to the dRGC research field. Check out the paper here: nature.com/articles/s4159… #3Brain #HDMEA #Electrophysiology #Retina

We’re at the Membrane Physiology Symposium 2026! Meet Amber Jolly at the Meritage Resort & Spa in Napa Valley, where we’re joining leading researchers advancing the understanding of membrane physiology and how it affects neuronal and cardiac function. From excitability in iPSC‑derived neurons to the role of ion channel dynamics in cellular function, Amber will be happy to show how CorePlate™ enabled HD‑MEA platforms deliver high‑resolution, label‑free functional insights across a wide range of applications. We’re also excited to be presenting two posters at the symposium: • Studying Single‑Cell Behavior at Network Scale with HD‑MEA • Electrophysiological Analysis of axoCells™ Atrial and Ventricular Cardiomyocytes Using CorePlate™ Enabled HD‑MEA Stop by to learn how HD‑MEA technology can support your research, see you in Napa Valley! #3Brain #HDMEA #MembranePhysiology #IonChannels #Electrophysiology #Neuroscience

New Application Note Available! We’re excited to share our latest application note: Assessing Primary Cortical & Hippocampal Neurons with the HyperCAM Alpha & CorePlate™ 6W High‑density microelectrode arrays (HD‑MEAs) continue to reshape how researchers study neuronal function and network dynamics and this new application note demonstrates just that. Using CorePlate™ 6W together with the HyperCAM Alpha, we functionally screen primary cortical and hippocampal neurons, capturing their individual baseline firing properties and their distinct responses to Cyclothiazide (CTZ). This work highlights how 3Brain’s HD‑MEA platforms enable: •High‑resolution, individual neuronal and network‑level electrophysiology •Side‑by‑side characterization of primary cortical and hippocampal neurons • Scalable pharmacological screening workflows Whether you are investigating neuronal function, modelling disease, screening compounds or advancing drug discovery, this application note provides valuable insights into how CorePlate™ technology can help you functionally screen your neuronal cultures. Check out the application note here: resources.3brain.com/f1/downloads/C… #HDMEA #Neuroscience #DrugDiscovery #Electrophysiology #3Brain #InVitroModels

Excited to see this ALS research move from preprint to publication! The newly published work from Vegard Fiskum et al. in Network Neuroscience offers powerful new insight into how motor neurons are affected in ALS. By combining human‑derived cell models with advanced functional analysis from CorePlate™ enabled HD-MEAs, they found that ALS neurons were hyperactive with smaller spike amplitudes. Further to this, they found that the ALS neuronal network was affected, showing an increased reliability on a small group of highly interconnected neurons to maintain function (increased rich club effect). Studies like this bring us closer to understanding, and ultimately treating this complex disease. Congratulations to Vegard Fiskum, Nicolai Winter-Hjelm, Nicholas Christiansen, Axel Sandvig and Ioanna Sandvig from @NTNU for this new publication! Check out the paper here: direct.mit.edu/netn/article/d… #Neuroscience #ALS #Neurodegeneration #Electrophysiology #HDMEA #NetworkNeuroscience #StemCells #iPSC

We're Heading to the French Alps for the 9th Cerebellum Days to join world-leading researchers at the CNRS Paul Langevin Center in Aussois from March 26th – 29th. If you’re interested in exploring the functional activity of your cerebellar slices, be sure to connect with Sercan Deniz (@DenizPhd). He’ll be there showcasing our CorePlate™ enabled HD‑MEAs & platforms. Ask us why CorePlate™ 3D is the most effective approach for studying brain slices, we’d be happy to show you how it can help you capture high‑resolution functional activity and accelerate your cerebellar research. See you in Aussois! #3Brain #HDMEA #Electrophysiology #Neuroscience #Cerebellum #Aussois2026

The countdown to SOT 2026 is on! Visit the 3Brain team from March 22nd – 25th at the San Diego Convention Center. Organoid and spheroid research continues to redefine the boundaries of toxicology, offering unprecedented models for human development, disease and screening purposes. 3Brain is proud to be at the forefront of this shift, we'll be at @SOToxicology to showcase how our CorePlate™ powered HD-MEA platforms can turn complex biological models into actionable data. Whether you are working with neuronal or cardiac cultures, our range of solutions from the precision of the BioCAM Duplex, to the high-throughput capabilities of the 96-well HyperCAM Delta, our platforms are designed to provide functional insights for enhanced compound screening. Stop by to explore how our single and multi-well platforms can accelerate your drug screening and neuro/cardiotoxicology research. #3Brain #HDMEA #Toxicology #Organoids #Neurotoxicology #Electrophysiology #2026SOT #ToxExpo