Sercan Deniz

Fuel Your Neuroscience Idea with €15,000! We know how challenging research can be, that is why we are offering a €15,000 award to help you achieve your research goals. Applications for the Massimo Grattarola Award are still still open, but not for long! Deadline: 01/10/2025 Take the next step. Apply for free now and push your research forward! 3brain.com/the-3brain-mas… #Neuroscience #Organoids #Spheroids #ResearchFunding #3DCellCulture #ResearchSupport #3Brain #HDMEA

Funding alert! It's this time of the year: the 2025 Massimo Grattarola Award, named in memoriam of a pioneer in Bioelectronics whose work laid the foundations for what would later become 3Brain, is officially open! All the information about conditions on 3Brain's webpage!

Placing an organoid onto a high-density microelectrode array (HD-MEA) with precision is crucial for capturing high-resolution electrophysiological data. While our 3D electrodes are designed to maximize signal quality, proper organoid placement remains a delicate yet essential step. To make this process easier, we’ve created a step-by-step instructional video to show you through the best technique for placing organoids onto our 3D HD-MEA - CorePlate™ 1W-3D 38/60/90 and securing them with our 1W Sample Holder Set to ensuring optimal signal acquisition. Whether you're new to 3D HD-MEAs, exploring our sample holder, or simply refining your technique, this guide has you covered. Let us know your thoughts or questions in the comments! Watch it here: youtube.com/watch?v=0ohvNg… Learn more about CorePlate™ 1W-3D: 3brain.com/technology/cor… #3Brain #Electrophysiology #HDMEA #OrganoidResearch #CorePlate #VideoGuide

What an incredible experience at the 4th Next-Gen Organ-on-Chips & Organoids Conference! We were proud to sponsor such an event and connect with so many researchers that put their effort into pushing the boundaries of organoid-based research. Particularly intriguing were the advancements in personalized drug screening using patient-derived iPSCs, which hold great potential for tailored treatments and disease modeling. The discussions on Bioconvergence were equally fascinating, highlighting the importance of enhancing stability and diversity in organoid models to drive more reliable and representative research. A big thank you to everyone who stopped by our booth to meet our scientists Sercan, Diego and Adil to learn how CorePlate™ is revolutionizing organoid research with its cutting-edge 3D electrode technology. We are looking forward to continuing these discussions and exploring new collaborations!! But if you did not have a chance to connect with us at the event, feel free to reach out, we are always eager to discuss how our solutions can help drive your research forward. 3brain.com/contact?utm_so… #3Brain #HDMEA #Neuroscience #Organoids #Electrophysiology #Innovation #ResearchBreakthroughs #CSEM2025

Are we ready for in vitro cognition? Biological AI delves into the possibility of using biological models like neuronal cell cultures and organoids to emulate human cognition, potentially training machine learning models. But what if computers themselves were biological? Biological AI pushes the boundaries of traditional computing by exploring the possibility of using human-brain-based circuits as alternatives to silicon chips. @NeuChiP is a project that promotes human stem cell-derived biological artificial intelligence. This cross-disciplinary consortium explores biologically trained machine learning models, as well as engineered biocomputers. At 3Brain, our mission aligns with NEU-CHiP's ambitious vision of a future where electronics and life sciences work together. We're proud to be a sponsor and active participant in making this a reality. Join the discussion! Register for the NEU-CHiP FENS FORUM 2024 Satellite Event, where experts will gather to discuss the use of Cortical Neurons for Biological Computing. Register here: neuchip.eu/fens-biocomput… Dive deeper into NEU-CHiP's latest publications and witness the rapid progress of the field: neuchip.eu/publications-a…

Microglia regulate neuronal development and synaptic refinement through Trem2 Recent research highlights the #immunesystem's role in #CNS development and ageing. Trem2, expressed exclusively in the #brain by #microglia, modulates energy metabolism and enhances phagocytosis. Variants on Trem2 are linked to neurodegenerative diseases like Alzheimer's. However, its role during neurodevelopment remains unclear. In this study, @EricaTagliatti et al. demonstrate that Trem2 deficiency disturbs neuronal transcriptomic and energetic profile during development, causing altered connectivity and behavioral defects in adult mice brains. Tagliatti and colleagues exploit 3Brain’s CorePlate™, a microchip-based technology to record and analyze high-content functional activity. Analysis on hippocampal brain slices in Trem2-/-mice revealed synaptic and functional alterations in the CA1 region but not in CA3. These findings, along with others, strongly suggest that the synaptic deficit in adult Trem2-/- mice specifically occurs in the CA1 region. This study opens the door to explore whether reduced neuronal activity in aging and neurodegeneration correlates with Trem2 deficiency Congratulations to @EricaTagliatti and colleagues. Publication: doi.org/10.1016/j.immu… Schedule a talk with our neuroscientists to discover how our technology can help you assess functional performance in ex vivo slices:

Interested in neuronal network functional analysis? Join us after the @EMBO Workshop 2024 for a unique opportunity to explore electrical recordings at network and single-cell levels. Exclusive 3Brain Lab Visit For EMBO Workshop attendees we are offering an exclusive visit on May 22nd (16:00-19:00) to our discovery lab in Genova to gain hands-on experience with our technology. Gain expertise on how to perform recordings and analyze data with our software, followed by networking and refreshments. Transportation provided. Spots are limited! Our Talk Don’t miss our talk at EMBO Workshop on using CorePlate™ to study Microglia’s impact on neuronal networks. Join @AlejandraCarreira on May 22nd, 12:30-12:45. Visit our booth to meet the rest of the team!

Just wrapped up an insightful experience at @OrganoidSphero1 JumpStart Lectures! Here are our key takeaways: • Organoids and organs-on-a-chip are pushing personalized medicine to the brink of reality. • Mechanobiology is gaining significant traction in organoid research. • Organoid intelligence is a promising frontier for investigating cognitive processes in vitro, opening new possibilities for studying brain function and neurological disorders. • Microchip-based technologies are essential for conducting functional assays of organoids. Thank you to those who came to our booth, it was a great opportunity to build new connections and share insightful ideas. Lastly, many thanks to our dedicated team members, @DenizPhd and Matthew Mullins. Together, we are driving innovation and shaping the future of organoid research.

🗓️Ready for @SOToxicology in Salt Lake City? Evaluation of toxicological effects on neuronal networks at single-cell resolution. Wondering how to assess #toxicology at single-cell resolution? Come visit our team, Tanya Hahn and @Marco_Aquila_82, at booth #2415 to discover more about assessing toxicological effects in #brainorganoids, #brainslices, #neuronalnetworks and other electrogenic cells such as #retina and #cardiomyocytes.

Haaave you met Matt? To my UK contacts, please welcome my new @3Brain team member Matthew Mullins, representative for the UK/Ireland area. He will reach out to you soon 😊

🗓️Join us at @OrganoidSphero1 JumpStart Lectures to explore the significance of recording from inside #organoids and more. Creating 3D models with #brainorganoids is invaluable, yet they present challenges: - Long protocols for organoid creation, often with single-use testing. - Surface activity recordings offer limited insights. The Accura 3D HD-MEA overcomes these challenges. Its thin microelectrodes penetrate organoids, capturing deep dynamics and interactions to provide accurate information about density connections in a 3D environment. Additionally, these microelectrodes are non-destructive to organoid’s cytoarchitecture, allowing for prolonged use in long-term studies. Join @DenizPhd's talk on February 29th at 10.15 am and visit us at booth #9 to explore more about recording cell activity in brain organoids, #neurospheroids, and other 3D cultures. Book a one-on-one meeting during #WORD2024: labhoo.com/event-book-mee…

@DrOzdinler Curious to hear about it! Carry on with the great research!

Getting ready for my talk. Wish me good luck.

Join us at the 𝗫𝗫𝗜𝗩 #SIRC 𝟮𝟬𝟮𝟯 congress in Imola, Italy (18–20 of October). Our team will showcase the application of our advanced HD Microelectrode Arrays. Visit our #3Brain booth to learn more. #hiPSC #cardioids #SIRC #bioengineering #XXIVCongressoSIRC

Exciting Postdoctoral Opportunity at the Dept. of Brain and Behavioral Sciences of the University of Pavia! Contact Lisa Mapelli at lisa.mapelli@unipv.it to learn more. #neurophysiology #universityofpavia #universityofpadova #postdoctoral

@3Brain is thrilled to award Dr. @RKastli with the 2023 Massimo Grattarola Award, supporting her research into the impact of #autism spectrum disorder risk gene mutations on developing human circuits using brain #organoids. Read more: 3brain.com/the-3brain-mas…

Dats ma team !

New #naturecommunications article from @neurofishh (BadenLab, @SussexUni, @SussexNeuro) comparing the eye to brain communication strategy between birds and mammals, with @3Brain HD-MEA data. #retina #MEA #electrophysiology Read more: nature.com/articles/s4146…

Great trip to Genova to visit @3Brain for @NeuChiP Thanks for hosting us, and for this fantastic workshop!

Today at 11 please attend our talk presented by Dennis Röhrig. We will present the advantages of using our technology especially Accura 3D for recording from complex #brain tissue such as #cerebral #organoids. #neurotech #research #neuroscience #NGI2023 #NGIFreiburg2023

Come and discover how our label-free, high resolution functional imaging neurotech can be used to study the impact of glia cells on neuronal activity. Our team (Elisa Monz and Dennis Röhrig) are there to answer your questions. #neuron #glia #brain #neurotech