isInfinityLogical?

Open source will win Locally hosted will win Sovereign super intelligence will win Personal research labs will win Empowered individuals will win Corporate spying will lose Selling of data will lose Price gouging will lose The faster you accept these things, the quicker you'll be prepared for whats coming

BREAKING🚨: Breakthrough trial shows stem cell injections can regenerate inner-ear nerves and restore hearing.😮

A lot of software is about to get a lot better, right before it becomes unnecessary.

Fantastic article!

😅

I’m going to tell you how much worse it was at the start of the PC Revolution for white collar workers trying to adapt, vs today with AI Today, presumably every white collar worker has access to a smart phone and/or a PC/laptop. Back then, a PC cost $4,995 , an off brand was $3,995. 5k in 1984 is about $16k today. It was really expensive. The only reason I could learn how to code and support software is because my job let me take home a PC to learn. By reading the software manual. Literally. RTFM. Or pay to go to training. Classes that started at hundreds of dollars then. It was expensive. It absolutely limited who could get ahead. Today, ANYONE can go to their browser, to the AI LLM website of their choice, and type in the words “I’m a novice with zero computer background, teach me how to create an agent that reads my email and …” That concept applies to LEARNING ANYTHING Think about what this means. Any employee of any company can say “ I need to learn how to xyz for my job , which is to do the following: Tell me what more information do you need to help me be more efficient, productive and promotable”. Or “ what new skills can you teach me that will help me reduce my chances of getting laid off “. Or “what suggestions do you have for me to communicate to my boss, who I barely know, to help my chances of staying employed “ These aren’t great prompts. But they are a start that anyone can take. Think about how incredible that is. Back in the day was so much harder for white collar workers. It was harder for new grads because unless they took comp sci, they probably had never used a PC. Big Companies are going to cut jobs. No question about it. Small companies is are going to need more and more AI literate thinkers who can help them compete or get an edge What I tell every entrepreneur, and it’s more crucial today. “ when you run with the elephants there are the quick and the dead. Adopt tech quickly , you can out maneuver big companies. “

Scientists just made 50-year-old skin cells behave like they’re 20 again. Researchers at the Babraham Institute in Cambridge have developed a groundbreaking method to reverse the biological aging of human skin cells by approximately 30 years, all while keeping them as fully functional adult skin cells. The team used a carefully controlled, short-term version of the Nobel Prize-winning Yamanaka reprogramming technique. By exposing adult skin fibroblasts to a specific set of reprogramming factors (the Yamanaka factors) for just 13 days—and then stopping the process early—they successfully “reset” many molecular markers of aging without pushing the cells all the way back to a stem cell state. After this brief treatment, the rejuvenated cells displayed a dramatically younger profile: their epigenetic clock (a measure of chemical tags on DNA that tracks biological age) and their gene expression patterns (the transcriptome) closely resembled those of cells from much younger individuals. Even more impressively, the cells behaved younger too. The treated fibroblasts produced significantly higher levels of collagen—the protein essential for skin firmness, elasticity, and wound healing—and they migrated faster to close an artificial “wound” in laboratory dishes compared to untreated older cells. The researchers also observed reversal of age-related changes in genes associated with diseases such as Alzheimer’s and cataracts, suggesting the technique could have broader therapeutic implications. While this work is still in its early stages and the precise mechanisms remain under investigation, the findings open exciting possibilities: one day, scientists may be able to selectively rejuvenate aging cells in the body to enhance tissue repair, improve healing, and potentially slow or mitigate some effects of age-related diseases—without the risks associated with fully reprogramming cells into stem cells. [Gill, D., Parry, A., Santos, F., Okkenhaug, H., Seale, M., Dobbs, L. J., Reik, W., & Ocampo, A. (2022). Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. eLife, 11, e71624. DOI: 10.7554/eLife.71624]

For $25 and a single GPU, you can now run 100 experiments overnight without designing any of them. Karpathy open-sourced autoresearch. 42,000 GitHub stars in a week. Fortune called it "The Karpathy Loop." Every article about it focused on the ML angle. They all missed the bigger story. The pattern underneath works on anything you can score with a number. Ad copy, cold emails, video scripts, job posts, skill files. Three files. One the agent edits. One it can never touch. One instruction file from you. Each cycle takes 5 minutes. Score went up? Git commit. Score went down? Git reset. Twelve cycles per hour. A hundred overnight. Karpathy ran it on code he'd already optimized by hand for months. The agent found 20 improvements he'd missed. 11% faster. Tobi Lutke pointed it at Shopify's Liquid templating engine. 53% faster rendering from 93 automated commits. I spent two weeks pulling the system apart. Today's guide shows you how to use it on the things you actually make every day. Six use cases, the three-step setup, and the eval mistakes that kill runs before they start. Full guide: aibyaakash.com/p/autoresearch…

Chamath Palihapitiya: "In Silicon Valley, I think it's fair to say we have had a lost decade… In one example, you have Elon. He's created reusable rocketry… electric cars… [while] fighting the government… We've created AirPods and Instagram Reels."

Your brain is under attack by a trillion dollar adversary intent on destroying it. This is your David vs Goliath. Resist the algorithm.

But what is <<nothing>>, but a virtual supposition. As always there is something, even in "nothing"... (?)

🚨 Elon Musk just said we're in the Singularity and honestly look at what happened TODAY alone: > Yann LeCun raised $1 billion to build AI that understands reality > Meta bought a social network where humans can't even post > Nvidia published a blueprint showing they own every layer of AI > Claude launched agents that do your senior dev's job for $15 > Economists said 20% of jobs are about to disappear > British startups stopped hiring humans entirely > Indian IT stocks collapsed because AI writes code cheaper than outsourcing.. It's just our regular Tuesday. Ray Kurzweil predicted the Singularity would hit in 2045. Elon just said it's already here. And after watching what happened in the last 12 hours, I'm not sure he's wrong.

AND objectively good intentioned AIs will outperform objectively bad intentioned AIs

This week feels like AGI meets sci-fi. First: @CorticalLabs ships the CL1 — real human neurons grown on silicon, running DOOM. A biological computer you can buy. (x.com/mastronomers/s…) Second: Eon Systems uploads a fruit fly. They took FlyWire's complete connectome — 130,000 neurons, ~50M synapses — simulated it with a biologically realistic neuron model, and connected it to a MuJoCo body. The simulated fly avoids toxic compounds. Sensory input to physical behavior, loop closed. (x.com/michaelandregg…) Same week. Two completely different paths to the same place. Cortical Labs (bottom-up): plate real neurons on a multielectrode array, give them a closed-loop environment, apply the free energy principle. No backprop. No gradient descent. They learn. The CL1 has ~800K neurons. The human brain has 86 billion. But the same principles apply. (pubmed.ncbi.nlm.nih.gov/36228614/) Eon Systems (top-down): take the connectome — the wiring diagram — and run it as a simulation. No real cells. Just the map, instantiated in silicon, driven by spiking neuron dynamics from real electrophysiology. Wire the motor outputs to a physics engine. Watch it move. (FlyWire: doi.org/10.1038/s41586… | Shiu et al.: doi.org/10.1038/s41586…) One starts with biology and asks what it can compute. The other starts with the map and asks how to run it. Both are making the same bet: that the structure of biological circuits — not their wetware substrate — is where intelligence lives.

Socialism is the theory that if you abolish profit, bread will somehow bake itself out of moral superiority.

"Evil cannot create anything new, it can only corrupt and ruin what good forces have invented or made" —J.R.R. Tolkien

😆

@Jason m.youtube.com/watch?v=jIS2eB…

Who are the best experts on Iran?

Pondering

Drones are easy to make, hard to stop, and bring Mutually Assured Destruction to conventional warfare.