Alessandro Beneduce

#PCRLV 2024 is just around the corner! Be part of this year’s brand new simulation-based #learning program on #RedoTAVI Join us in London! 🇬🇧🤖❤️ @DrArifK @myriam_akodad Vinnie Bapat @David_Meier_ @ignamatsant @fra_giannini1 @nbuzzatti @dmylotte #TAVI #TAVR

Join #EAPCI in Milan at the #SimLabs of @MyUniSR for Level 2 of the EAPCI Educational Pathway: The Structural Course 🫀 🗓️April 29&30 2026 will be two days of intensive, expert-led training with simulation workshops and interactive case-based discussions 🧑‍⚕️👩‍⚕️ 🔗 Secure your spot now: esc365.escardio.org/event/2476 @escardio Endorsed by @sicigise #EAPCIfamily #EAPCIcommunity #EAPCIEducationalPathway

Among patients with atrial fibrillation at high risk for stroke and bleeding, left atrial appendage closure was not noninferior to medical therapy in reducing the risk of stroke, embolism, major bleeding, or death at 3 years. Full CLOSURE-AF trial results: nejm.org/doi/full/10.10… Editorial: Left Atrial Appendage Closure — Another Overused Method in Cardiology? nejm.org/doi/full/10.10…

All the explanations I’ve heard today for the negative CLOSURE-AF result—some so strained they’re almost impressive. 1) The devices were “outdated” and therefore responsible for excess complications (the usual argument that things only go wrong elsewhere). 2) DAPT was used after LAAO, which is now said to be obsolete because of bleeding concerns compared with DOAC-based strategies (a claim that is often repeated, less often demonstrated). 3) Stroke rates were similar, so the signal is attributed mainly to bleeding and procedural issues—as if that were a minor point. 4) The composite endpoint is criticized for mixing different mechanisms, although if anything it should have favored non-inferiority. 5) The early phase of enrollment is invoked to argue that complications are not representative of current practice (again, complications seem to belong to others). 6) And then there are the usual remarks about loss to follow-up, crossovers, and lack of blinding. What seems to be missed in this accumulation of arguments is straightforward: the burden of proof lies with LAAO, not with the control arm. The issue is the strength of the evidence supporting LAAO, not medical therapy, which remains the reference standard.

Extended-length sheaths for TF-TAVI in hostile aortic anatomy: feasible, safe, and may enhance procedural control without increasing complications. #TAVI #CardioTwitter eurointervention.pcronline.com/article/extend… @kobari0601 @lulic_d @DrArifK @YinghaoLim @YWillemen @GintautasBieli1

When your transseptal LV angiovac thrombectomy does not go as expected… but you are ready with the @ONOCORvascular in the ascending aorta 🙃

@g_giustinoMD @ONOCORvascular Expect the best but prepare for the worst! Great save @g_giustinoMD 🚀

Age alone appears to be the wrong filter for AF ablation. In REHEALTH AF, very elderly patients (≥80) saw no clear overall drop in major events, but ablation improved symptoms, quality of life, NT-proBNP, left atrial size, and preservation of cognition/frailty. Selection matters. t.co/mIVeymBqY4 #AFib #CardioTwitter @JACCJournals

Medical therapy works 80M w Severe MR sent for evaluation for MTEER After optimizing GDMT 👉TEE Here comes the difficult part: convincing pt/family procedure unnecessary after being referred for it @djc795 @TCT_ME_ @Abdul_alkindy @RHAAttar @alexsfelixecho @SachinGoelMD

This state-of-the-art review outlines current evidence on the mechanisms, prevalence, clinical relevance, and management of TAVI thrombosis and highlights ongoing clinical trials investigating this condition. eurointervention.pcronline.com/article/transc…

Key updates in the dyslipidemia management guidelines ahajournals.org/doi/10.1161/CI… 1️⃣ Martin/Hopkins equation or Sampson/NIH equation is preferred over the Friedewald equation to estimate LDL-C 2️⃣ ASCVD, CKM syndrome, type 2 diabetes & ⬆️ TG, measurement of apoB is reasonable

IVL in MAC - it's here @purviparwani @onco_cardiology @iamritu sciencedirect.com/science/articl…

In an international, randomized trial involving patients with acute venous thromboembolism, the risk of clinically relevant bleeding was significantly lower with apixaban than with rivaroxaban during the 3-month treatment period. Full COBRRA trial results: nejm.org/doi/full/10.10…

Finally published: the COBRRA trial, the first randomized head-to-head comparison of major DOACs — something the companies would never have done themselves, as a direct confrontation goes beyond their commercial interests. This was driven by independent investigators. The results somewhat support the idea of apixaban being the “safer” DOAC. That said, the list of study limitations is long, and for me, labeling something as “safe” is not enough — after all, even placebo is “safe” when it comes to bleeding. nejm.org/doi/full/10.10…

@g_giustinoMD Amazing work @g_giustinoMD 🤩

In case you were wondering how big of a thrombus you can remove safely from the left atrium… Check this out!! 🩸⁦⁩ Removal of Massive Left Atrial Appendage Closure Device–Related Thrombus With Complete Embolic Protection: Step-by-Step Technique jacc.org/doi/10.1016/j.…

Our state-of-the-art review on pulmonary HTN due to left heart ds (group 2) now publ in JACC. Poor prognosis, esp when pre-capillary PH develops (PVR >2 WU - CpcPH). No specific Rx exist. We're starting the PULSE-LHD trial of PA denervation in 500 pts with group 2 PH and CpcPH.

Combined procedures could become quite common in the EP world. Still a matter of concern for our SHD community. @PCRonline

LIVE Eductional Case: combined Mitral TEER and LAA closure or isolated LAA closure 📺 pcronline.com/Cases-resource… With operators @nicolasdumonte1, @didier_tchetche, L. Bonfils, L. Lepage Procedural Analyst: @DrGarot Key moments 19:36–22:17 – Description of devices 23:40–24:38 – Transseptal puncture for TEER and LAAC 24:51–50:00 – MitraClip G5 implantation 55:40–1:00:04 – Watchman FLX Pro implantation 1:02:55–1:10:12 – Procedural analysis of the LIVE case 1:14:00–1:15:25 – AnchoMan device implantation 1:25:01–1:27:56 – Procedural analysis of the recorded case Editorialised by @MartineGilard #PCRLV #interventionalcardiology #CardioEd

Step up the interventional ladder in beautiful Milan with the EAPCI Structural Course! 🏎️🇮🇹 📍 Sim Labs of @MyUniSR 🗓️ April 29 & 30 2026 👩‍⚕️👨‍⚕️With special registration rates for #EAPCIYoung Members This #handson course is based on the EAPCI Core Curriculum to deliver foundational knowledge through #simbased training  Find out more and register 👉 esc365.escardio.org/event/2476 #EAPCIfamily #EAPCIcommunity #EAPCIeducationalpathway @escardio Endorsed by @sicigise

I can almost hear the bells of the Duomo ringing for more #Education in #StructuralInterventions🔔 Looking forward to climbing the next step of the #EAPCIEducationalPathway in Milan — advancing skills in #TAVI, #TransseptalPuncture and #MTEER through simulation-based training and lectures by #KOLs. The future of structural intervention is hands-on, team-based and simulation-driven.