Agnieška Brazovskaja

Our @NatureComms study on human liver regeneration reveals cellular gene expression changes linked to tissue architecture in regenerating liver lobules. Congrats to all co-authors! 🎉 @TreutleinLab @GrayCampLab @MPI_EVA_Leipzig @UniLeipzig #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

Today something from real life. It was great to be part of this cooperation and to supervise parts of this study. I am more than happy seeing it published in @NatureComms #liver #regeneration

Happy to see that our paper on archaic admixture and its phenotypic impact in Papua New Guinean populations is out now in @PNASNews! Thanks to all co-authors for this fun collaboration @genomicstartu pnas.org/doi/10.1073/pn…

The evolution of developmental biology through conceptual and technological revolutions: Cell cell.com/cell/fulltext/…

Out today in @NatureBiotech! PhD students & postdocs: there's a trick – overlooked and underused – for having new ideas in the creative process. Talk science 1 on 1 with a science buddy that you trust and think of it as an improvisation. nature.com/articles/s4158…… @MartinJLercher

There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in @Nature today, we start tackling this question by combining forebrain #assembloids with CRISPR screens to map >400 disease genes onto stages of human cortical interneuron development. Using engineered lines, regionalized neural #organoids and over 1,000 #assembloids, we discovered a group of disease genes that interfere with GABAergic neuron generation or migration, including some surprising disease mechanisms. Check out the video below for details. This work was led by the fearless @XianglingM in the lab!! In collaboration with Bassik lab & @panagiog lab! Article here: nature.com/articles/s4158… Supported by the @BrOrganogenesis @StanfordBrain @StanfordBioX @nyscf @cziscience

What makes our cells human? The evolution of human development is undeniably fascinating. It is an exciting time to explore the details! We, @brainevodevo, @craiglowe, @KlkUmut, @NatureRevGenet review and suggest new inroads: rdcu.be/c4Pno #sapiens #evodevo #organoids

PhD position alert! We are looking for a PhD student working on an exciting collaborative project with @falk_lab. The project is embedded in an interdisciplinary CRC Exploring brain mechanics @neuro_mechanics! Read the full description below.

Congratulations to @ABgnieska for defending her thesis! Elegant data and presentation! It was great fun working with you and being part of your journey! @TreutleinLab @MPI_EVA_Leipzig. It's unfortunate that Svante missed and you lost the ear, but worse things can happen in a PhD!

Glad to see this paper out in @Transl_Psych! Fun collaboration with @GoldLabCharite and all the other contributors from #NESDA @ESTbiobank @unitartu @MPI_EVA_Leipzig nature.com/articles/s4139…

Excited to share our new work on thymic epithelial cell progenitors in @Nature. Together with the Boehm lab at @mpi_ie we combined scRNA-seq with a new CRISPR barcoding mouse to identify an early and a postnatal adult TEC progenitor population. 👇🧵 nature.com/articles/s4158…

Have you seen our latest special issue on the #immunesystem in #development and #regeneration? Packed with reviews, research articles, Development at a glance, an editorial from the guest editors @FGinhoux and Paul Martin and much more. tinyurl.com/rnsuc6yh

Tremendous advance by @slinnarsson lab: EEL-FISH enables multiplexed smFISH of ~500 genes across large tissue volumes. All methods and data are openly released, including spatial atlases of the mouse brain and human cortex: biorxiv.org/content/10.110…

Spatial Liver Cell Atlas out @CellCellPress. Joint effort from Guilliams & Scott labs @KC_DC_01. From whole genome, we select top genes & proteins and provide 100-plex transcriptomics and proteomics atlas, providing markers for immune & hepatic cells. 1/8 cell.com/cell/fulltext/…

cell.com/cancer-cell/fu… Out today - the single-cell atlas of human small cell lung cancer, a collaborative effort co-directed by the amazing @dana_peer with heavy lifting by first authors @jmchan88 @AlvaroQuintanal @GaoVianne and @Yubin_Xie. An @sloan_kettering dream team. #LCSM

In the latest issue! Organs-on-a-chip models for biological research dlvr.it/S6r7lN

Online now! A single-cell atlas of gene expression and chromatin accessibility of the human developing cortex reveals lineage-determining transcription factors and identifies prioritized mutations for Autism Spectrum Disorder #developmentalbiology bit.ly/3CJoQMf

Excited to share our new preprint on liver zonal regeneration:biorxiv.org/content/10.110…. Acetaminophen overdose leads to massive necrosis of pericentral hepatocytes. Yet, within four days the liver fully regenerates (1/7).

It was a pleasure to write this review on Spatial Transcriptomics for @nature with @anj_rao, @BarkleyDalia and @gustavo_franca, where we review the technologies, exploratory data analysis, & its utility in different experimental designs, and integrations. nature.com/articles/s4158…

We are excited to open (free!) registration for Next Generation Genomics 2021! Amazing line-up of junior speakers developing new methods in single-cell/spatial analysis, genome engineering, comp. bio, and population genetics. Register+submit an abstract at nextgengenomics.org