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1/ Thrilled to share our new paper, out today in @Nature: "Non-invasive profiling of the tumour microenvironment with spatial ecotypes".
Paper (open access): nature.com/articles/s4158…
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Aaron Newman Lab
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Aaron Newman Lab
@AaronNewmanLab
Computational biology, cancer genomics, & stem cell bioinformatics lab @Stanford @czbiohub
Stanford, CA Katılım Ekim 2021
272 Takip Edilen1.2K Takipçiler
An honor to discuss our recent @Nature paper with @EricTopol on his Ground Truths podcast! See his fantastic thread below and a link to our conversation here: erictopol.substack.com/p/a-breakthrou…
Eric Topol@EricTopol
For treatment and outcomes for cancer, the tumor microenvironment (TME) is pivotal, but we've never had a non-invasive way to assess it. Until now, a blood test breakthrough! (<-a term I use sparingly) Pictured below, schematically, the TME surrounds the cancer cells and consists of immune cells, blood vessel (endothelial) cells, fibroblasts and matrix
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Can a blood test read the spatial organization of a tumor?
In a recent @Nature study, Zhang et al. (@Wubing44589261, @AaronNewmanLab) introduced Liquid EcoTyper, which infers spatial tumor ecotypes from cfDNA methylation, associated with immunotherapy benefit in melanoma. 🧵1/4
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1/ Thrilled to share our new paper, out today in @ScienceMagazine! We built a pan-cancer spatial atlas of tertiary lymphoid structures (TLSs) and developed computation and AI frameworks to study TLS biology at scale.
science.org/doi/10.1126/sc…
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GitHub: github.com/digitalcytomet…
Web interface: spatialecotyper.stanford.edu
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15/ We are grateful to our funding sources including @theNCI, @TheVFoundation, @CancerRF, @MelanomaReAlli, and @Ludwig_Cancer. We deeply thank the patients and their families whose generous contribution of samples made this research possible.
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1/ Thrilled to share our new paper, out today in @Nature: "Non-invasive profiling of the tumour microenvironment with spatial ecotypes".
Paper (open access): nature.com/articles/s4158…
English