A. Heifets

In honor of the 50th anniversary of the Apollo moon landing, it's a pleasure to share the great accomplishments of the Atomwise team! #drugdiscovery #ai #moonshot lnkd.in/gwtP3Qk

@SandyofCthulhu Is it possible that you typed “This will be a challenge versus the enemy’s intelligence.”?

While waiting for the grandkids to show up for Christmas dinner later on today I decided to work on my science fiction roleplaying game. I typed almost a whole paragraph of gibberish. One sentence read: Yjod eo;; nr s vjs;;rmhr brtdid yjr rmr,ud Omyr;;ohrmvr My fingers were one step off on the keyboard, and now I have no way to recover what I wrote in my inspiration except to paintakingly move my fingers one step over and try to re-type the gibberish. So I guess Happy "Yjod eo;;" to you all, and to all a good night.

Be the optimizer. Train MNIST—by hand. Ride a saddle into a valley, watch FP16→FP32: crunchy → smooth. Zoom step size and see curvature, tweak batch size, or run SGD if you can’t descend by hand. Live (desktop is better) @ humandescent.net

.@AtomwiseInc publishes landmark @SciReports paper on the power of #AtomNet for #AI #drugdiscovery @AbeHeifets @Nature drugdiscoverytrends.com/why-atomwise-s…

Have you ever done a dense grid search over neural network hyperparameters? Like a *really dense* grid search? It looks like this (!!). Blueish colors correspond to hyperparameters for which training converges, redish colors to hyperparameters for which training diverges.

Scoop: Atomwise has hired a CMO w/ 25-plus years experience in the drug industry, as the AI biotech pivots from partnerships to pipeline CEO Abe Heifets talked with me about the new focus, starting with TYK2, and why faster isn't necessarily better endpts.com/atomwise-ceo-o…

@chrissyfarr Patients.

In health care, who are you betting on to be the biggest winner in the AI race?

Only 3 days left until Ai4 2023 in Vegas on August 7-9. Our panel “AI Powered Pharmaceuticals: Intelligent Drug Discovery And Clinical Trials” will gather pharmaceutical leaders to discuss the ways AI is making an impact on Pharma. Passes are selling fast: ai4.io/usa/

My #Tecbio list. This is my list of companies using #AI and #ML in biotech drug discovery. 1. $ABCL 2. $RLAY 3. $SDGR 4. $RXRX 5. $EXAI 6. $ABSI watch list 7. @AtomwiseInc private If you have a name I am missing please let me know. Your top pick in #Techbio is?

Great to see ⁦@AbeHeifets⁩ and chat about AI & drug dis at #bio2023

@KRHornberger If drug discovery is done in humans, then you're making a stronger claim, to wit: "Our understanding of disease biology is simply too poor to model clinical outcomes right now". If you're right about _that_, then the concern about AI is a simple corollary.

@AbeHeifets I’m not sure that it would. A wise pharma executive I know routinely says: drug discovery is done in humans. Our understanding of disease biology is simply too poor for AI to model clinical outcomes right now. Wouldn’t mind if that changed someday though.

@KRHornberger Put another way, and leaving AI out of it, do you think that adding (or subtracting) 50% to a preclinical budget in dollars or time would change the clinical failure rate?

@KRHornberger Some clinical trial failure rate is due to imperfect correlation between preclinical models and clinical outcomes, and so would remain even if we find the "best" molecules (according to preclinical models). But do you mean there's no chance to improve the quality of cmpds today?

A new @AtomwiseInc preprint led by @Artur_Mell and @sauloho in collaboration with @drGregBowman lab @penn: Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors. biorxiv.org/cgi/content/sh…

Check out @AtomwiseInc's neural database paper presentation at #NeurIPS22 this morning. Excellent work by Aryan Pedawi, Pawel Gniewek, Chaoyi Chang, and Brandon Anderson in my team. #AI #drugdiscovery #ML arxiv.org/abs/2211.04468

amazing to see @genomicsdoc moderating a session on cost effective drug dev session with @AbeHeifets @AtomwiseInc @emulateinc @khoslaventures #HLTH2022 #drugdevelopment #lasvegas

Excited for the future of computational drug discovery!

Very proud of the entire team for launching this collaboration!

I'm delighted to welcome David Thomson, Jon Barr, and Jeff Cerio to the team! fiercebiotech.com/medtech/atomwi…

Come hear about the great progress that the Atomwise team has delivered when we present at #JPM22 this year!

@max_hodak I think you'll appreciate Mitchell and Webb's take: youtube.com/watch?v=CS9ptA…

“identity theft” is such a wild crime It has nothing to do with someone stealing your “identity,” whatever that means, and everything to with companies that have poor access controls slandering you and somehow society is programmed to be like, this makes sense