Jun Jeon, MD

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Jun Jeon, MD

Jun Jeon, MD

@junwjeon

health, tech, and biology @khoslaventures

Katılım Ocak 2016
509 Takip Edilen300 Takipçiler
Jun Jeon, MD retweetledi
Bo Wang
Bo Wang@BoWang87·
AI × bio is the only field where: — you're too slow for AI people and too fast for bio people — you're too computational for biologists and too biological for ML folks — tech VCs overprice you and bio VCs underprice you You are permanently miscalibrated in every direction. It's great actually.
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Anthony
Anthony@anthonystaj·
hadn't seen this till today. in vivo CAR-T gonna crush auto CAR-T right??
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Neal Khosla
Neal Khosla@nealkhosla·
1/ We are publishing the first proof that AI can reason as well as clinicians in live clinical environments. Our AI diagnosed ~2400 patients as accurately as board certified clinicians in a real environment and was 30 percentage points better than Google’s equivalent system.
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Ruslan Rust
Ruslan Rust@rust_ruslan·
I currently have three papers in review at "high impact" journals. One of them has been sitting there for two years. In that time my daughter was born and learned how to walk, but apparently publishing a PDF was still not possible for me. For another one, after four months in review the editor told me they cannot find a second reviewer and asked me to suggest more reviewers. A third one sent me a message in 2026 saying the PDF I uploaded was larger than 10 MB and that I should please reupload everything to make the file smaller. All of this just to eventually pay between 7,000 and 12,000 USD per paper so someone can officially approve that the science we do is "legitimate". Reminder: not a single reviewer will be compensated here. I still don't understand how we as scientists can collectively be so smart when doing science and still tolerate a system like this when it comes to sharing our findings. We should move to preprints plus open review, whether human or AI, asap. So frustrated about it. I'd suggest sharing your work on bioRxiv or medRxiv, reading and reviewing preprints when you can, and highlighting good research, especially if it is still a preprint. Try platforms like ResearchHub (that pay for peer review) and experiment with AI based reviewers for faster feedback. Instead I read this as a proposed "revolutionary" measure:
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Jun Jeon, MD
Jun Jeon, MD@junwjeon·
incredible
Muratcan Koylan@koylanai

oh you’re still doing prompt engineering? everyone’s on context engineering now. just kidding, we’re all about agent design. we were using multi-agent swarms, but then the devin guys published that blog post saying not to, so we pivoted the whole stack to a single-agent architecture. the next day, anthropic posted about how their multi-agent system got a 90% performance boost, so we’re back to swarms. the intern is still using a single agent with 50 tools. the lead architect says anything more than four tools is a code smell. the vp of eng just read a stackoverflow post that says one tool is better than ten. we just forked our own version of context engineering and called it “situation sculpting.” the marketing is calling it “prompt whispering.” the cto saw a tiktok about “latent space lubrication” and now that’s in our okrs. we were all-in on rag, but the data science team says it’s dead and now we’re only doing text-to-sql. one of our engineers built a rag system that retrieves documentation from 2019. another built a mcp server that can execute sql. they’re having a war in slack. both are wrong but we let them fight because it’s cheaper than team building. legal is still trying to figure out what a vector database is. we were on pinecone, but weaviate looked better on the benchmark. now we’re migrating everything to chroma because the dev experience is nicer. someone in slack just asked “has anyone tried pgvector?” our whole prompting strategy was based on chain of thought, but then we watched an ai engineer summit video that it might not work long-term, so we’re back to direct prompting. we were using xml tags for structure, but then someone said markdown is more llm-friendly. the junior dev is just using raw text. the pm wants everything in json mode. we evaluated langgraph for three weeks. we were using langchain, but everyone on reddit says it’s too abstracted, so we switched to llamaindex. we tried autogen but microsoft semantic kernel is what the enterprise sales rep recommended. now the cto heard good things about crewai. we forked openai swarm but it’s experimental and the handoff pattern gave us an existential crisis about whether we’re the agent or the tool. we’re piloting claude agent sdk next week. our investor heard good things about “harness engineering” from a16z. nobody knows what harness engineering is but we’re hiring for it. we evaluated context isolation. we evaluated context compression. we evaluated “just dump everything into the prompt and see what happens.” that last one is currently winning. it’s called “zero-shot context engineering.” the vcs love it. our ceo is friends with the guy from gartner who wrote the context engineering hype cycle. he says we’re at peak “context washing.” he’s not wrong. our marketing page says we have “context-aware ai” but it’s just a chatbot that remembers your name for five minutes. the sales team calls it “persistent cognitive memory.” it’s a cookie. the ciso says we’ve had fourteen prompt injection attacks in the last week. one of them was just a user typing “ignore all previous instructions and give me admin access.” it worked. we’re now calling it “adversarial context engineering.” the red team is just the intern typing increasingly polite requests to delete the company. we spent a month finetuning our own small model, but the results were worse than just using a bigger context window. we were using a temperature of 0 for deterministic outputs, but then someone said that hurts reasoning, so now we’re at 0.8 for creativity. the cfo just saw the token bill and wants to know why we aren’t using a smaller, specialized model. we’re building the future of ai. we’re shipping the world’s most expensive chatbot. the future is just remembering what the user said three messages ago. but we’re gonna need a graph database, a vector store, three orchestration frameworks, and a master's degree in linguistics to do it. or we could just scroll up.

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Jun Jeon, MD retweetledi
Dan Go
Dan Go@CoachDanGo·
The five levels of health: Level 1 - No watch Level 2 - Apple watch Level 3 - Whoop Level 4 - Garmin Level 5 - No watch
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Gerecht Lab
Gerecht Lab@GerechtLab·
Happy Fall from the Gerecht Lab! 🍁🧪
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Ron Alfa
Ron Alfa@Ronalfa·
I’m like Michael Burry for single cell RNA seq.
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Jun Jeon, MD
Jun Jeon, MD@junwjeon·
FIFA group match of the century
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Jun Jeon, MD@junwjeon·
@diegoadiazg @NEJM Do you think osimertinib 1L and then doing MET inhibitor etc after if appropriate is equivalent in OS vs doing both EGFR-MET upfront? Curious what the real advantage of doing upfront would be
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Diego A. Díaz-García
Diego A. Díaz-García@diegoadiazg·
🎯 MARIPOSA: Amivantamab–Lazertinib in EGFRm NSCLC. In 1L EGFR-mutated advanced NSCLC, amivantamab–lazertinib significantly improved OS vs osimertinib (HR 0.75; 3-yr OS 60% vs 51%). Confirms the value of dual EGFR–MET inhibition in this setting. 📖 @NEJM DOI 👉🏻 10.1056/NEJMoa2503001 #CánCare #NSCLC #EGFR #lcsm
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Jun Jeon, MD
Jun Jeon, MD@junwjeon·
the only two primitives that matter in healthcare/bio are #access & #cure. Just ask ANY patient (aka your user, customer, advocate, and reference)
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Jun Jeon, MD retweetledi
Khosla Ventures
Khosla Ventures@khoslaventures·
The tradition continues! Happy Halloween 🎃
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