Adam Bentham

With Bluesky now having some nice critical mass I'm no longer going to be actively using Twitter. My account will stay up but the lights are off. Come find me on bluesky if you haven't already!

Pls RT 🚨I'm looking for someone excited about #proteindesign and #synbio to join my lab @durham_uni and the @CPBM_heddlelab to undertake a PhD using #synthetic knottins as novel #bioinsecticides. If you're interested please get in touch and check out the advert below 👇

@adamrbentham.bsky.social

With Bluesky now having some nice critical mass I'm no longer going to be actively using Twitter. My account will stay up but the lights are off. Come find me on bluesky if you haven't already!

RhoFold+ is an end-to-end language model-based deep learning approach for predicting 3D structures of RNAs. nature.com/articles/s4159…

A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀 @chrisfrank662 @DominikSchiwie0 Lara Fuss @hendrik_dietz biorxiv.org/content/10.110…

We're happy to present a pre-print from the Hogenhout lab (@SaskiaHogenhout), describing how a family of proteases in aphid oral secretions suppress plant immunity

Incredibly excited to share new results from Nabla Bio where we show we can design antibodies de novo for use in therapeutic discovery. We introduce JAM, an AI system we’ve developed to design de novo antibodies with good affinities, early stage developability, and function. We’re seeing success across a range of soluble and hard-to-drug membrane proteins including a Claudin and a GPCR. We’ve extensively tested these designs in our wet lab and included detailed data and controls, providing the first clear demonstration of how de novo design could expand the scope and efficiency of therapeutic antibody discovery. 🧵 Technical report: …bla-public.s3.us-east-1.amazonaws.com/2024_Nabla_JAM… Blog: nabla.bio/news/denovo

We’re delighted to share our latest preprint from the Hogenhout lab (@SaskiaHogenhout, @JohnInnesCentre) on the molecular mechanisms of plant-aphid interactions. We show how the aphid Mp10 effector protein acts as a local anesthetic, suppressing plant perception of aphid attack.

So glad to share that it's just published online. 'Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants'. nature.com/articles/s4146…

5 days left to apply for the postdoc and research scientist positions in cryo-EM & protein design in our lab! 🔬🦠🧬 They're fully funded for 4 years. Salary: 42,800 euros gross per year. See details below:

Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…

AlphaBind, a Domain-Specific Model to Predict and Optimize Antibody-Antigen Binding Affinity - Encode antibody and antigen with ESM2-nv (ESM2 but on NVIDIA), concatenate embeddings and feed into a lightweight transformer (4 attention heads, 7 layers) to predict binding affinity - Pretrain AlphaBind on 7.5M antibody-antigen affinity measurements from AlphaSeq (yeast display), then finetune for each parent antibody using ~30K variants - Use ESM2-nv masked prediction to guide antibody mutations, filter candidates with AlphaBind affinity predictor Preprint: biorxiv.org/content/10.110…

I'm thrilled to announce that in 2025, I'll be joining the Spanish National Cancer Research Centre (CNIO) in Madrid to launch the Castells-Graells Lab! 🚀Check out our brand-new lab website: rcglab.com @CNIOStopCancer

Great news: -@rcastellsg is one of the most talented researchers I know. -A Spanish institute facilitates the return of a top researcher from @UCLA. -My collaborator/good friend will now be closer. -There are two positions open with competitive salaries! Apply below👇

Plant pattern recognition receptors: from evolutionary insight to engineering nature.com/articles/s4157…

Happy to see this accepted and out on First Look at @MPMIjournal You can read the final unformatted version here👇 doi.org/10.1094/MPMI-0…

Please retweet!🚨 We're hiring! 🚨 My lab @IPMBSinica is looking for postdocs and research assistants to join us in studying NLR resistosomes in plant immunity, with opportunities in both fundamental and translational research. 🌱🔬 Learn more: sites.google.com/view/chwlab/ho… or DM me!

So happy to see the final version of our paper on the structure of the sensor-activated NRC2 hexamer online! Congrats to @JMadhuprakash and the whole team 👏 Check out Madhu's and @amiralito_'s threads below for the key highlights 👇🧵 science.org/doi/10.1126/sc…