Alan Ames

NEW ARTICLE: RESEARCH: MEBENDAZOLE in Cancer - 2025 Iran Paper - How Mebendazole overcomes Cancer Drug Resistance! 2025 Aliabadi et al - Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy Cancer drug resistance significantly reduces the effectiveness of current anticancer treatments This highlights the need for developing new multi-targeting drugs that are more cost-effective, have fewer side effects, and remain effective against cancer. Drug repurposing offers a promising solution over expensive targeted therapies. Repurposing Mebendazole: it’s already been given to millions of people at high doses with a very good safety record, repurposing it for cancer is much faster and cheaper than inventing a brand-new drug. How MEBENDAZOLE Fights Cancer and Cancer Drug Resistance. This review breaks down six key ways Mebendazole attacks cancer. Mebendazole hits all of them at the same time, which is why it may overcome resistance better than single-target drugs: 1. Disrupts the cancer cell’s skeleton (microtubules) MBZ binds to the same spot on tubulin that the cancer drug colchicine uses. This stops cancer cells from properly dividing (they get stuck in the G2/M phase of the cell cycle and eventually die).It’s similar to some existing chemotherapies but appears safer. Starves the tumor of blood supply (anti-angiogenesis) 2. Tumors need new blood vessels to grow and get nutrients. MBZ blocks a key signal called VEGFR2, so the tumor can’t build those vessels. 3. Triggers programmed cell death (apoptosis) MBZ tips the balance of proteins inside the cell (raising “death-promoting” ones like Bax and p53, lowering “survival” ones like Bcl-2 and XIAP). This activates enzymes called caspases that make cancer cells commit suicide in an orderly way. 4. Forces cells to “eat” themselves (autophagy) Autophagy is the cell’s recycling system. MBZ can ramp it up so cancer cells digest their own damaged parts until they die or become easier to kill. 5. Mebendazole wakes up the immune system It shifts immune cells called macrophages from a “tumor-friendly” state (M2) to a “tumor-killing” state (M1 type). It also increases signals that attract other immune attackers and works especially well when combined with radiation. 6. Stops cancer from spreading (anti-metastasis and MMP inhibition) Cancer cells use enzymes called matrix metalloproteinases (MMPs) to chew through surrounding tissue and travel around the body. MBZ blocks them. Additionally, MBZ calms down several overactive growth pathways that cancers use to survive and resist drugs (examples: Hedgehog, ERK/MEK, MYC, NF-κB, AKT, etc.). What the evidence shows Lab dishes (in vitro): Very low concentrations (often under 1–5 micromolar) kill or slow down breast, colon, lung, stomach, ovarian, melanoma, and brain cancer cells. MBZ works even better when paired with standard chemo or radiation. Mice (in vivo): Oral doses (10–50 mg/kg) shrink tumors, reduce the number of polyps in colon cancer models by up to 90 %, slow metastasis, and improve survival. Tumors weighed far less (e.g., one study: ~2 g vs. 12 g in untreated mice). Humans (early clinical trials): Small studies in brain tumors (Glioblastoma) and gastrointestinal cancers showed it is safe even at high doses (up to 4 g/day). One glioma trial reported median survival around 21 months when combined with standard treatment. The main practical challenge (and the fix) MBZ doesn’t dissolve well in water and isn’t absorbed very efficiently from the gut into the bloodstream or tumors. The review discusses new “drug delivery” solutions that researchers are testing: polymeric nanoparticles nanostructured lipid carriers micelles nanosuspensions These make Mebendazole more soluble, help it reach the tumor, and may let doctors use even lower doses. Main Takeaways from the Paper: Mebendazole is a strong candidate for drug repurposing in cancer because it: 1. attacks cancer from many angles at once (great for beating resistance), 2. is already proven safe and cheap, 3. works in many different cancer types in the lab and in animals, 4. shows early promise in people, 5. and can be combined with existing treatments. CONCLUSION: Overall, the paper is optimistic: Mebendazole could become a low-cost, low-toxicity addition to the cancer-fighting toolbox, helping patients whose tumors have stopped responding to standard therapies. In short, this review makes a detailed, evidence-based case that an old “worm pill” might help solve one of the toughest problems in modern cancer treatment - drug resistance - by hitting the cancer where it hurts in multiple ways at the same time.

Dermatology is wrong about the sun. And it's killing people. I'm a dermatologist. 226 publications. I should know. Avoiding the sun increases the risk of dying as much as being a smoker. We can fix it. For decades, dermatology's message has been simple: avoid the sun. Wear sunscreen. Seek shade. UV causes skin cancer. End of discussion. That message is incomplete and outdated. People are dying because of it. Lots of people. The evidence has gotten strong enough that the field needs to update it.🧵

We once considered a Cholesterol Level of 350 perfectly normal & healthy. Then it was lowered to 300. Then to 240. Then to 190. Now doctors want your levels as low as statins can force them — no matter what. Every single time the “safe” number drops, millions more healthy people are suddenly labeled as needing medication. This isn’t medicine. It’s a business model. Statins generate over $22 billion every year. The truth is, the cholesterol hypothesis has been heavily questioned for decades. The famous Framingham Heart Study that helped launch the fear actually showed that for every 1 mg/dL drop in cholesterol per year, there was an 11% increase in both coronary and total mortality. Large reviews of elderly populations (over 68,000 people) found that those with the highest LDL cholesterol lived the longest. Yet studies on statins show they extend average life expectancy by only about 3.2 days. Lowering cholesterol harms the body because cholesterol is essential. It forms every cell membrane, protects your brain, produces hormones, and helps repair arteries. **Statins come with a long list of serious side effects, including:** - Liver inflammation & damage - New-onset Type 2 diabetes - Heart failure & cardiomyopathy - Vertigo, dizziness, cognitive impairment - ALS, aphasia, dementia & Alzheimer’s - Cancer - Pancreatitis - Parkinson’s - Muscle tearing & rhabdomyolysis - Fatigue, weakness & neuropathy - Hormone deficiency - MS, epilepsy & clinical depression **Real culprits behind heart disease:** chronic inflammation, seed oils, excess sugar, and processed carbohydrates — not cholesterol itself. Your body makes most of its cholesterol for good reason. Forcing it dangerously low can create more problems than it solves. Share this with anyone being pushed toward statins. Higher LDL in the elderly is linked to longer life in multiple studies. The constant lowering of “normal” cholesterol numbers benefits drug sales far more than patients. Food is medicine. Real healing starts with what you eat.

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