Alan Carson

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Alan Carson

Alan Carson

@AlanCarson15

Neuropsychiatrist Royal Infirmary of Edinburgh and Professor University of Edinburgh, past-President of FND Society and of BNPA

Katılım Haziran 2015
337 Takip Edilen4.9K Takipçiler
Alan Carson
Alan Carson@AlanCarson15·
@ajlees @smead2 I think larger more routine integration of phenotyping and biomarkers would help prevention work- can’t realistically wait for dementia as final outcome
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Andrew Lees
Andrew Lees@ajlees·
@smead2 @AlanCarson15 Much more clinical and epidemiological work on brain health, more research on cognitively intact centenarians like David Attenborough whose brain is slmost certainly full of plaques and more clinical and biological study of large AD families like the Paisa
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Andrew Lees
Andrew Lees@ajlees·
Proponents for the new anti-amyloid drugs make a comparison with the multiple sclerosis scene 20 years ago believing their introduction will lead to a momentum swing in dementia care and more efficacious immunotherapy All the same i am pleased they are not available on the NHS
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Alan Carson
Alan Carson@AlanCarson15·
@ProfRobHoward @ajlees I don’t think the success will come from amyloid targets i was more thinking of the pipeline of an advanced integrated clinical / research platform
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Robert Howard
Robert Howard@ProfRobHoward·
@AlanCarson15 @ajlees I don’t think the comparison is fair. These drugs are the high point of 25 years refinement of amyloid antibodies and there isn’t anything coming behind them that is anywhere near licensing.
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Alan Carson
Alan Carson@AlanCarson15·
@moreisdifferent Is this not X all over the ssme people commenting on neuroscience, geopolitics, transgender science, crop rotation, you name it- maybe it shows that true expertise matter
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Alan Carson
Alan Carson@AlanCarson15·
@ajlees Agreed not without its problems but MS care compared to when i was a houseman…
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Andrew Lees
Andrew Lees@ajlees·
@AlanCarson15 I agree but it has led to acknowledged overdiagnosis of MS and inappropriate use of potentially toxic therapies in some instances, and has had negligible impact on neurodegeneration
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Alan Carson
Alan Carson@AlanCarson15·
Does anyone think VAR has improved football. It certainly detracts from the matchday experience with long pauses and it doesn’t help get big calls right is there apoint to it- can we said we trialled it but it failed theguardian.com/football/2026/…
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Alan Carson
Alan Carson@AlanCarson15·
@mvianin @WillStewNeuro There is strong evidence that neither the mental state aspects or the anger supposedly associated with cte occur at any higher rates- the first thing to do is to drop these from criteria. Second thing is to add specific rider not better explained by functional cognitive disorder
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Michael Vianin
Michael Vianin@mvianin·
The diagnostic accuracy of traumatic encephalopathy syndrome (TES) for chronic traumatic encephalopathy neuropathologic change (CTE-NC) was driven by exposure to repetitive head impacts rather than proposed clinical features.
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Alan Carson
Alan Carson@AlanCarson15·
@mecfsskeptic It was part technological, there just wasn’t the methods, part specificity ( ie it’s not), part philosophical - the psychiatrists involved had always recognised brain involvement but doubted that elaboration would lead to a fix so not a priority- ie position on genetics now
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ME/CFS Science
ME/CFS Science@mecfsskeptic·
9) Not sure why these buspirone tests were never followed up. Perhaps there was some (unpublished) negative data, or maybe the test had too many confounders. Some also suspect that prolactin response works by blocking dopamine receptors rather than as a serotonin agonist.
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ME/CFS Science
ME/CFS Science@mecfsskeptic·
1) With genetic evidence pointing to the brain, there is renewed interest on the S4ME forum for the buspirone tests done in the 1990s. A couple of small studies found an increased prolactin response in ME/CFS patients but these findings were never studied further.
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Robert Howard
Robert Howard@ProfRobHoward·
If you set yourself up as a critical psychiatrist, you can’t really complain if other psychiatrists criticise your ideas and assertions - particularly when they do it politely and with evidence. Thank you @tylerblack32. We all look forward to a response to your specific points.
Tyler Black, MD@tylerblack32

x.com/i/article/2055…

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Alan Carson
Alan Carson@AlanCarson15·
Nice read but element of new wine in old bottles the biosome-psychosome-socialsome. Engel should have bern better at marketing
Agustin Ibañez@AgustinMIbanez

Brain–body-environment interactions must move beyond isolated exposures toward the expotype: the dynamic configuration of physical, social, lifestyle, and internal factors that jointly shape brain–behaviour phenotypes. At @NatRevNeurosci (nature.com/articles/s4158…), we propose a future agenda to assess the exposome as a complex, time-varying system that requires nonlinear models to capture interactions, thresholds, synergistic effects, and cross-domain buffering mechanisms. Although predictive machine learning can support individual risk estimation, the next frontier is to move from prediction to mechanism, from association to dynamic synergetic inference. Multivariate learning, causal machine learning, aging clocks, longitudinal designs, and generative biophysical digital twins are beginning to provide this bridge. Brain–body–environment diversity can reveal how ecology becomes biologically embedded. We call for a future exposomic neuroscience that integrates nonlinear temporal modeling, generative mechanisms, and population diversity to understand, simulate, and modify trajectories of brain aging and disease. Congrats Sarah Genon, @MasoudTahmasian & @INM7_ISN

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FT UK Politics
FT UK Politics@ftukpolitics·
Robert Jenrick’s wife was lawyer for donor at centre of illicit funding row ft.trib.al/yyLtney
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The News Agents
The News Agents@TheNewsAgents·
“Farage said Brexit will make you richer - lo and behold, it did make one person much richer!” Nigel Farage says the £5m gift he received was given as a “reward” for campaigning for Brexit - we thought it was for security? @maitlis | @jonsopel | @lewis_goodall
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Jon Stone
Jon Stone@jonstoneneuro·
Just over 4 weeks left until the @FNDSociety 2026 Baltimore meeting! zurl.co/qqGFg If your budget can stretch, PLEASE consider booking the conference hotel. zurl.co/SDhZS Doing so will help make the meeting a financial success. Thank you!
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Dr Willie Stewart
Dr Willie Stewart@WillStewNeuro·
75% of those meeting proposed clinical criteria identifying chronic traumatic encephalopathy (#CTE) during life do not have the pathology at autopsy. Raises serious concern re consequences of incorrect diagnoses in at risk groups @PennNSG @Penn nature.com/articles/s4159…
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Functional Neurological Disorder Society
📢 We are one month away from the FNDS Conference in Baltimore June 13th-16th ⏳There is still time to register (through May 27th before fees increase) and book your hotel (through May 15th) 🖱️Click on the link below to find all the details and register fndsociety.org/biennial-meeti…
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Colin the Dachshund
Colin the Dachshund@DachshundColin·
"I once received £5m, a further £1m, an £800k house, helicopter trips and a trip to the Maldives, and wasn't expected to do anything in return for it."
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