Alex J Keeley

🧵 New paper from MRC Strep A research team out today in @NatureMedicine nature.com/articles/s4159… On development of #StrepA #Immunity over life course in #TheGambia raising hope for vaccines on the horizon 1/

#Identification of protective antibodies in children marks a major advance toward a #StrepA #Vaccine, offering potential to prevent hundreds of thousands of deaths worldwide each year. @sheffielduni @NatureMedicine doi.org/g9wjrh medicalxpress.com/news/2025-08-s…

[1/2] "Streptococcus pyogenes leads to 500,000 deaths annually, many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine development." @NatureMedicine nature.com/articles/s4159…

#NewStudyAlert 🆕research led by scientists @mrcunitgambia @LSHTM uncovered vital evidence that could fast-track the development of a vaccine against Streptococcus pyogenes (Strep A), a major cause of childhood illness & death worldwide. Read more 👉 tinyurl.com/44azs8dy

On this note: Huge progress being made by @PendaJohm in establishing a community advisory board for Strep A research... Many new projects underway, lots of opportunity to collaborate... And substantial momentum towards Strep A vaccine trials @mrcunitgambia fin/

But biggest thanks to the families, the Alkalo, and community of Sukuta. Sharing the first results with you was a special moment (x.com/edwinarmitage/…) We look forward to the next event to show just how impactful your contribution has been. 13/

🧵 New paper from MRC Strep A research team out today in @NatureMedicine nature.com/articles/s4159… On development of #StrepA #Immunity over life course in #TheGambia raising hope for vaccines on the horizon 1/

Great thread: Where #StrepA burden greatest frequent lineage replacement seen. Interesting points: "vaccines without broad cross-lineage protection may also lead to S. pyogenes lineage replacement." "need to do better surveillance from carriage and non-invasive disease"

Building from: thelancet.com/journals/lanmi… which you can read all about 🧵👇: x.com/edwinarmitage/… Feedback and discussion welcome:

📢 Preprint - not peer-reviewed🤞: Development of #immunity to #StrepA in The Gambia. We assessed IgG to conserved and M protein antigens across the life course, exploring association with protection against infection: medrxiv.org/content/10.110…