Waggoner Lab

Programming macrophage polarization with synthetic cytokine receptors dlvr.it/TTXNMn

CAR19 Tregs treat murine chronic Graft-Versus-Host Disease through immune suppression in absence of measurable B-cell cytolysis @JCI_insight insight.jci.org/articles/view/…

Migration-dependent extrafollicular programming of pre-plasmablast age-associated B cells drives lupus pathogenesis @jclinicalinvest jci.org/articles/view/…

Epigenetic signatures mark early peripheral human B lineage bifurcation and differential transcriptional profiles in mature populations @NatureComms @JoSpencerLab @KingsCollegeLon nature.com/articles/s4146…

A favorable follicular helper CD4 T cell programming characterizes neutralization activity in chronic HIV infection @jclinicalinvest jci.org/articles/view/…

Sleep restriction reprograms systemic immunity through NK and T cell crosstalk nature.com/articles/s4154…

Macrophage-derived itaconate acts as a paracrine metabolic brake that blocks MCT1-dependent succinate uptake and restrains brown adipose tissue thermogenesis @NatMetabolism @DanaFarber @evanna_mills nature.com/articles/s4225… nature.com/articles/s4225…

Preprint: Programmable Signaling Drives CAR T Cells to Enhanced Functional States papers.ssrn.com/sol3/papers.cf… @Stanford @ScienceKyle

Review @MolTherapy Recent Progress in the Rational Design of mRNA Vaccines cell.com/molecular-ther…

FDA-approved fulvestrant-induced CAR phase separation enables precise control of CAR T antitumor function @CellStemCell cell.com/cell-stem-cell…

Philippe Bousso (1971–2026) @ImmunityCP cell.com/immunity/fullt…

MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion @ImmunityCP @SantoshVardhana @VardhanaLab @MSKCancerCenter @tanmana_mitra cell.com/immunity/fullt…

Review @ImmunityCP @ordovas_phd Nasal immunity in respiratory viral infection, transmission, and protection cell.com/immunity/fullt…

Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity @ImmunityCP cell.com/immunity/fullt… 🇨🇳

Antigen-restricted Candida albicans Th17 cells link oral-gut immunity and adopt pathogenic features during intestinal inflammation @ImmunityCP cell.com/immunity/fullt…

Preprint: Circulating CD5⁺ dendritic cells link gut microbiome function to immunotherapy response in cancer patients researchsquare.com/article/rs-101… @ChandraJanin

Preprint: Functionally and epigenetically distinct programs define the heterogeneity of trained immunity researchsquare.com/article/rs-102… @Radboud_Uni

Absolutely love it when a plan comes together @ResearchHub . Our project you guys funded? It worked. Amazing pics incoming.

@weijunwu7 @CellCellPress I do not see anything on #PubPeer for this paper or for the senior author's body of scholarship. Please document your specific concerns somewhere so that they can be evaluated rather than making unsubstantiated insinuations that could harm reputations/careers Thank you

@LabWaggoner @CellCellPress Be careful of this paper, academic misconducts, such as Image duplications including WB bands and flow cytometry plots, were presented in the part of results.😂

Human ILC2, unlike mouse counterparts, show cytolytic activity in tumor cells through granzyme B-mediated induction of cell death, opening possibility of ILC2 immunotherapy @CellCellPress Jianhua Yu & Michael Caliguiri cell.com/cell/fulltext/…

@LocasaleLab Everywhere I have worked, investigations were thorough and cheaters were punished (at least locally, some escaped the institution/country before serious consequences). Important to root out the fraudulent programs to preserve the valid science

@LocasaleLab You fail to acknowledge what I have seen at 3 different institutions. There is strong incentive to determine if there is actual fraud by a single investigator to protect the overall enterprise. Covering up a single PIs bad behavior to save an R01 or two versus $300M portfolio 🤨

The main reason universities do not investigate research misconduct in good faith is that they are financially interested in the outcome. The grants are contracted with and paid to the institution. Then the same institution is responsible for deciding whether research conducted under those grants was fraudulent. That is an obvious conflict of interest. Universities have every incentive to minimize misconduct, protect grant revenue, avoid fines, limit reputational damage, and quietly make the problem disappear. Until individual investigators bear far more direct responsibility for stewarding public grant money, nothing will change.