Allie Greaney

83 posts

Allie Greaney

Allie Greaney

@AllieGreaney

MSTP MD/PhD student studying virus evolution and immunity in the @jbloom_lab at @fredhutch @uwgenome @UW_MSTP. she/her

Seattle, WA Katılım Mart 2020
445 Takip Edilen875 Takipçiler
Allie Greaney retweetledi
Tyler Starr
Tyler Starr@tylernstarr·
We first report the effects of all mutations on ACE2 binding affinity and protein folding stability. Interactive versions of these maps (together maps from prior SARS2 variants), are available here: jbloomlab.github.io/SARS-CoV-2-RBD… Like prior maps, we see wide tolerance to mutation.
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Tyler Starr
Tyler Starr@tylernstarr·
Our newest study is up, where we report deep mutational scanning data in the Omicron BA.1 and BA.2 receptor-binding domains biorxiv.org/content/10.110…
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Helen Chu
Helen Chu@HelenChuMD·
New paper from @jbloom_lab about the importance of ACE2 expression on target cells on SARS-CoV-2 neutralization - thanks #HAARVI participants for contributing to these studies.
Bloom Lab@jbloom_lab

In new study, we examine how target cell ACE2 expression affects #SARSCoV2 neutralization biorxiv.org/content/10.110… We find high-ACE2 cells emphasize role of RBD antibodies in serum & lower ACE2 cells reveal more neutralization by antibodies to other regions of spike. 🧵 below:

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Bloom Lab
Bloom Lab@jbloom_lab·
In new study led by @dbacsik, we show single influenza-infected cells produce wildly different numbers of viral progeny: biorxiv.org/content/10.110… Surprisingly, cells that transcribe the most viral mRNA are NOT ones that produce the most progeny virions. Explanatory 🧵 below
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Bloom Lab
Bloom Lab@jbloom_lab·
In new study, we examine how target cell ACE2 expression affects #SARSCoV2 neutralization biorxiv.org/content/10.110… We find high-ACE2 cells emphasize role of RBD antibodies in serum & lower ACE2 cells reveal more neutralization by antibodies to other regions of spike. 🧵 below:
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Allie Greaney
Allie Greaney@AllieGreaney·
Was a pleasure to contribute to this very cool study looking at how heterologous boosting elicits new versus boosted original antigenic sin antibody responses in mice from @victora_lab !
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Bloom Lab
Bloom Lab@jbloom_lab·
We have a position in the Bloom lab for a research tech interested in using deep mutational scanning to study evolution of viruses including SARS-CoV-2 & influenza: careers-fhcrc.icims.com/jobs/22925/res… (And while this ad is for a tech, we are always open to inquiries from postdoc candidates)
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Allie Greaney
Allie Greaney@AllieGreaney·
If you’re into viral, antibody, or protein evolution, check out the 🌟 Starr lab 🌟! Can confirm that @tylernstarr is one of the most brilliant, fun, and supportive scientists out there! Already envious of the new folks who get to work with you!
Tyler Starr@tylernstarr

🥳 Excited to share that the Starr Lab is coming to the University of Utah @UofUBiochem! Check out the lab website to see where we’re headed in our studies of protein evolution in viruses and immunity starr.biochem.utah.edu

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Adrienne Shapiro, MD, PhD
Adrienne Shapiro, MD, PhD@DrAShapiro·
#NewProfilePic & update (don't be fooled by the 🔺pic, staying masked in my new role): Excited to be @uwdgh as an Assistant Professor August 1, 2022, working @ the intersection of #TB, #HIV, & #COVID prevention science, global health (incl. #vaccine) equity, and clinical ID! 🌍
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Pitt Provost
Pitt Provost@PittProvost·
Congratulations to #Pitt faculty member Tera Levin on receiving a Charles E. Kaufman Foundation grant to support your project “Playing with fire: How bacteria deploy self-targeting antimicrobials during inter-bacterial battles.” #Pittprovost #UniversityofPittsburgh #H2P
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Keşfet

@khdcrawford @CaelanRadford @jbloom_lab @dbacsik @victora_lab @BiochemistryACS @tokuriki_lab @tylernstarr