Amabel Kim

@BWDionne @davidwkubiak @jeffpears0n @GReardonPharma @MOppenheimRx academic.oup.com/ajhp/article/7…

Last ID #OTILT!🦠 Cefazolin and Rifampin combination can cause increased risk of clotting. When used together, the disassociation of the N-methylthiodiazole side chain can lead to decreased levels of vitamin K-dependent clotting factors and result in a prolonged INR

@BWDionne @davidwkubiak @jeffpears0n @MOppenheimRx @GReardonPharma ncbi.nlm.nih.gov/pmc/articles/P…

#OTILT Hepatic encephalopathy is the a neurological issue in liver disease 🚨Antibiotics for hepatic encephalopathy? Think rifaximin! Rifaximin can be used by: reducing gut bacteria, cutting ammonia production, and preventing harmful gut bacteria from entering the bloodstream.

@BWDionne @davidwkubiak @jeffpears0n @GReardonPharma @MOppenheimRx atsjournals.org/doi/abs/10.116…

#OTILT Keep an 👁️ out for these rx combinations when verifying orders: INH and pyridoxine! INH can form toxic metabolites that can disrupt vital vitamin B6 metabolism. ⬇️ can lead to peripheral neuropathy Co-prescribe pyridoxine to support nerve health during INH therapy.

@BWDionne @davidwkubiak @jeffpears0n @GReardonPharma @MOppenheimRx ncbi.nlm.nih.gov/pmc/articles/P…

#OTILT For patients that start on diuretics for SBP, remember🧐 the golden ratio for spironolactone to furosemide: 100:40 mg daily! Dose adjustments would be titrated based off of the ratio and is thought to help increase ascitic fluid opsonic activity and prevent K+ wasting

@BWDionne @davidwkubiak @jeffpears0n @GReardonPharma @MOppenheimRx accessdata.fda.gov/drugsatfda_doc… ncbi.nlm.nih.gov/pmc/articles/P…

#OTILT Make sure to check these 3 things when starting an azole: QTc interval, LFTs, and DDIs! DDIs may warrant a dose adjustment. For instance, the package insert recommends caution when using doses >20 mg for atorvastatin if given with itraconazole and to monitor for rhabdo

@BWDionne @davidwkubiak @jeffpears0n @GReardonPharma @MOppenheimRx sciencedirect.com/science/articl…

#OTILT "Lady Windmere Syndrome" is used to describe a specific pulmonary infxn pattern caused by MAC. Commonly seen in older women that suppress their cough reflex and sputum, which is thought to make them more susc. to MAC infxn. Can lead to r middle lobe syndrome in some pts

@BWDionne @davidwkubiak @jeffpears0n @GReardonPharma @MOppenheimRx ncbi.nlm.nih.gov/pmc/articles/P…

#OTILT Ruxolitinib, a janus kinase inhibitor, is used as treatment of myeloproliferative disorders. TB reactivation has been reported for some patients that took ruxolitinib. Providers may recommend to get a TB test before initiating therapy to determine if it is safe to initiate

@BWDionne @davidwkubiak @jeffpears0n @GReardonPharma @MOppenheimRx sciencedirect.com/science/articl…

#OTILT PSSA is staph aureus tht is both susceptible to penicillin and methicillin. It is a strain of Staph aureus that can be treated with penicillin and related antibiotics, such as cefazolin which is 1st-gen cephalosporin. Tx options: penicillin, ampicillin, or cefazolin

@BWDionne @jeffpears0n @davidwkubiak @MOppenheimRx @GReardonPharma academic.oup.com/jid/article-ab…

#OTILT Mycobacterium fortuitum is a nontuberculous mycobacterium that are associated with skin and soft tissue infections, and pulmonary infections. Treatment 💊 can be challenging due to resistance but include: clarithromycin, amikacin, ciprofloxacin, imipenem, linezolid

@BWDionne @davidwkubiak @jeffpears0n @MOppenheimRx @GReardonPharma ncbi.nlm.nih.gov/pmc/articles/P…

#OTILT S. aureus is not a common cause of UTIs. Could be d/t: - enter the bloodstream and can reach the urinary tract - pts w/catheters - structural issues in the urinary tract S. aureus in the urine may prompt getting blood cultures to determine the root cause! 🧐