autistic

Then: what supplement should I take to not get sick? Me: it’s winter? Eat an orange 🍊

Why you should absolutely AVOID berberine for metabolic health and the actual reason (and way) to use it: First of all, berberine is NOT a supplement for metabolic health and it shouldn't be treated as such. If absorbed (which luckily happens very rarely with regular berberine, 0.36% to be exact) it can inhibit complex I of the respiratory chain, meaning that its a direct mitochondrial toxin. Berberine is doing exactly the OPPOSITE of what you want to happen in individuals with metabolic syndrome. Complex I is the primary way of extracting energy from glucose and if you inhibit it your body has to compensate by increasing glycolysis, with this you're essentially mimicking a hypoxic state. However, berberine exerts quite profound and unique effects on the gut microbiome. Firstly, it shows anti-microbial effects against a whole host of pathogenic bacteria and fungi like E. coli and Candida, and it also has some inhibitory effects on biofilm production by said fungi. But most interestingly it shows a modulatory effect on the whole microbiome shifting it towards less pathogenic bacteria, and increased beneficial bacteria such as the butyrate producing strains. Butyrate itself should have an entire post dedicated to it since it has an incredibly broad spectrum of effects of which most are far beyond the gut microbiome (like increased BDNF, protection from Alzheimer's, Parkinson's, depression, diabetes and more). But for the scope of this post it's main effects are enforcing the integrity of the intestinal barrier preventing gut dysfunction and protecting from conditions such IBS and IBD. Below is a figure displaying the effect of berberine on the microbiome of beagle dogs. Thus, because of these effects you ideally want to keep berberine in the gut and prevent large amounts of absorption. You can do this through several ways, first take it away from meals, don't eat any fat that may enhance the absorption. Second, you may want to take with a binder like fiber or perhaps charcoal. Lastly, you don't want to use it for extended periods of time, so I'd recommend cycles of 7 days, or maybe 14 if you have particularly bad symptoms. What I personally did was 1000mg in the morning and 1000mg in the evening for a week straight. Though I should note that these dosages can (and likely will) cause diarrhea.

fixed my gut now i feel tingly and cant stop smiling at anything and everything im in heaven

If you feel silly, just remember that there are still people out there who think that veggies, nuts, legumes, seeds and grains are superfoods.

🚨 WATCH: Nigel Farage says the Government shouldn't ban Kanye West from coming to the UK "If we start banning people from entering the country because we don't like what they say, I worry where that ends up... it's a dangerous path to go down"

Are the Greens actually extreme? Have people just been lying about them? Do they REALLY want totally open borders? Let's have a look at their updated migration policy. 🧵

There is a corner of the wellness world that has decided sugar is bad but natural sugar is medicine. Sugar from a Haribo: inflammatory, addictive, metabolic chaos. Sugar from a Medjool date: ancient, healing, the food of kings. I want you to understand that your pancreas does not know what a Medjool date is. Your pancreas knows glucose. It receives glucose, it releases insulin, and it does not stop to enquire whether the glucose arrived via a bag of sweets or a fruit that has been romantically described as "nature's candy" in someone's recipe blog. The glucose molecule is the glucose molecule. The insulin spike is the insulin spike. The metabolic response is the metabolic response. "But dates have fibre." Yes. They also have 18 grams of sugar per date. The fibre modulates the spike slightly. It does not convert the date into a metabolically neutral food. It converts it into a slightly slower version of the same thing. This is people who have a sugar addiction finding a category of sugar they're allowed to call health food. Fructose from a Coke. Fructose from an organic Medjool date. Your liver processes both. Your liver does not have a "locally sourced" setting. Eat the animal. Leave the dates to people writing cookbooks with the word "nourish" in the title.

It’s also worth noting that when and how you eat is just as important as what, this is because the gut microbiome is very circadian sensitive and circadian disruption leads to dysbiosis and circadian entrainment leads to better microbe diversity.

In the Minnesota Starvation Experiment they ate ~1,500–1,800 kcal/day for 6 months (down from ~3,200 kcal). Result: organs shrank (including cardiac muscle), ~25% bodyweight loss, marked drop in metabolic rate, lower body temperature, slower heart rate, lower blood pressure, edema, fatigue, weakness, irritability, depression, strong food obsession, reduced libido, and prolonged recovery during refeeding.