AncaSt

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AncaSt

AncaSt

@AncaSt13

Nephrology Specialist, Assistant lecturer University of Medicine and Pharmacy Gr.T.Popa

Iaşi, România Katılım Nisan 2021
408 Takip Edilen79 Takipçiler
AncaSt
AncaSt@AncaSt13·
Time for ⚖️
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ERA - European Renal Association
What should you consider when supervising a child on an adult dialysis unit? 🚸In this e-seminar Rumeyza Kazancioglu provides many practical advices. 🟢Moderator: @RukshanaShroff 🟢Panellists: Jerome Harambat and @LynseyStronach
ERA - European Renal Association tweet media
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AncaSt
AncaSt@AncaSt13·
Can we use gene therapy in kidney disease? Check out the answers in the following e-seminar👇
ERA - European Renal Association@ERAkidney

Gene therapy in inherited kidney disease: are we there yet❓ Gene and RNA therapies aim to fix disease at its genetic cause, not just treat symptoms. For inherited kidney diseases, this raises a new question: are we finally close to real cures? Speaker: @gdorval12 Moderator: Roman-Urlich Müller Panellist: Eris Olinger Panellist: Moin Saleem

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ERA - European Renal Association
ERA e-seminars🚨 Mineral and bone disorders in peritoneal dialysis patients Addressing the complexities of bone health in PD patients is vital for improving long-term outcomes 🎙️ Luciano Pereira ⚖️ Juan Miguel Díaz Tocados 👥 Gaetano Alfano & Maria Jesus Lloret
ERA - European Renal Association tweet media
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AncaSt
AncaSt@AncaSt13·
Obesity in CKD patients is becoming more prevalent, so we need to be on high alert 🚨 How can we help our patients? Check it out in this great 👇e-seminar @ERA26
ERA - European Renal Association@ERAkidney

🧶1/10 Do you treat CKD patients with Obesity? 🚨 Threadorial alert on Nutritional Management of Obesity and CKD. #ERA26 #nephrology An @erakidney e-seminar by Prof. Allon Friedman🇺🇸 Moderator: Prof. Bengt Lindholm🇸🇪 Panellists: Prof. Maria Inês Barreto Silva🇧🇷 & Prof. Carolina Gracia-Iguacel🇪🇸

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Dr Rishabh Jain
Dr Rishabh Jain@DrRishabhOnco·
Noninferiority trials are NOT “no difference” trials. ⚠️ They can be statistically inferior… and still be called “noninferior.” 🤯 Here’s the simplest way to interpret any noninferiority trial like a pro 🧠👇 🧪 Noninferiority = “not substantially worse” ✅ Not about proving equality ✅ Not about “p>0.05 so same” 🎯 Key requirement: The lower bound of the CI must stay above a pre-set margin (Δ) 📌 Why do we even accept this? Because the new treatment may offer: 💊 less toxicity 💰 lower cost 🕒 easier delivery 😌 better QoL But here’s the trap 👇 A treatment can be: ✅ Noninferior AND ❌ Statistically worse than standard 🧠 Biggest mistake in medical Twitter discussions: ❌ “No significant difference → noninferior” ✅ Wrong. Noninferiority needs a margin + CI rule. 🔥 The authors recommend something CRITICAL: ✅ Use TWO margins, not one 1️⃣ Clinical noninferiority vs standard (Δclin) 2️⃣ Efficacy vs no treatment (Δeff) Because even if you’re “close to standard”… you might be no better than placebo 😬 📌 Also important: ⚠️ ITT analysis can be anti-conservative in noninferiority Protocol violations make groups look similar → falsely supports NI ✅ Best practice: report BOTH 🧾 ITT + Per-protocol and require NI in both 🧠 One-liner takeaway: “Noninferior ≠ equivalent ≠ superior.” 📖 Full paper in comment ⬇️ #MedTwitter #OncoTwitter #ClinicalTrials #Biostatistics #EBM @OncoAlert @myesmo @esmo_open @asco
Dr Rishabh Jain tweet media
Dr Rishabh Jain@DrRishabhOnco

Stop assuming “Non-Inferior” means “Equal.” 🛑 It is the most dangerous misunderstanding in trials today. 🏎️ Superiority trial (Mercedes) Claim: I am better. Rule: You must beat the standard of care. Reality: If you only tie, you lose. 🚗 Non-Inferiority trial (Toyota Camry) Claim: I am not meaningfully worse, but safer, cheaper, or easier. Rule: You must stay within a predefined margin. Win condition: Similar efficacy with real advantages in safety or QoL. ☠️ The trap everyone misses If a superiority trial fails with p > 0.05, you cannot relabel it as non-inferior. That is not clever statistics. That is incorrect science. ✨A failed superiority trial is just that. A failure. Always read beyond the abstract. #MedTwitter #stats #EBM #MedEd @OncoAlert @ASCO @myESMO @ESMO_Open

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AncaSt
AncaSt@AncaSt13·
A topic very dear to me - assessing CV risk in CKD patients and discovering how many CKD patients are actually cardiorenal patients. Check out this amazing e-seminar on the new CV risk formulas and how can they help us in CKD👇
ERA - European Renal Association@ERAkidney

How might the newest cardiovascular risk formulas completely reshape what we think we know about heart risk in chronic kidney disease (CKD)? Speaker: Jose M. Valdivielso Moderator: Evangelia Ntounousi Panelist: Johannes Stegbauer and Claudia Torino

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ERA - European Renal Association
🩺 Turning global commitments into action on kidney health A new NDT article shows how the ERA’s ABCDE Framework translates the WHO Kidney Health Resolution and the UN Political Declaration on NCDs into concrete prevention and policy action for #CKD. Words matter. Action matters more. 🔗 Read ERA’s full statement 👉 bit.ly/49ifFEX 🔗 Read the NDT article 👉 bit.ly/4qMgrj4 @EKHA_EU #KidneyHealth #NCDs #UNHLM #WHO
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NDT
NDT@NDTsocial·
Evolving strategies for early diagnosis, proactive prevention and treatment of CKD 🆓 access: doi.org/10.1093/ndt/gf…
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