Ángel Robles Marhuenda

New content online: Fertility, pregnancy and lactation in women with systemic lupus erythematosus dlvr.it/TRw43w

"Chronic active Epstein-Barr virus disease: molecular pathogenesis, evolving concepts, and emerging therapies." Read in Blood: ow.ly/pRAV50YCtlz #EpsteinBarr #BloodJournal #EBV

Profesionales sanitarios, gestores y pacientes se unen por primera vez en España en la "Alianza Estratégica para la Salud Vascular". 👉10 entidades sanitarias diseñan un mapa de ruta para reducir el impacto de uno de los principales problemas de salud pública en nuestro país. 👉Se plasma en un Manifiesto, que llama a la acción a todos los agentes implicados en la prevención, diagnóstico, tratamiento y control de las enfermedades vasculares f.mtr.cool/mlbesqrfzm @Icomem_Oficial @seacv_esp @secardiologia @Sociedad_SEMI @SEDISA_NET @fep_pacientes @cuidarcorazon @Farmaceuticos_ @CGEnfermeria

Whole-exome seq study of 174 patients with SLE treated with glucocorticoids identified heterozygous variants in ANK1 and EPB41, associated with higher risk of steroid-induced osteonecrosis of the femoral head Arthritis & Rheumatology doi.org/10.1002/art.70…

This is what Israeli settlers do to Palestinian olive groves in the West Bank. And they never face consequences. Spare us the hypocrisy.

Editorial in A&R: Interferon with Still Disease and the Treatment Conundrum By exploring the role for IFN-I in SD and SD-LD, Ombrello and colleagues have advanced the science/knowledge for this rare condition. While many of the correlations were made using a single timepoint analysis of ISG-28 scores in largely refractory SD patients, the genetic underpinnings support a role for IFN-I in a subset of SD individuals doi.org/10.1002/art.70…

El bloqueo del complemento en el riñon. Más allá del eculizumab. @SENefrologia @SOMANEorg @Nefrologialapaz

Autologous CD19 CAR T-cell therapy for pediatric and adult systemic lupus erythematosus: a phase 1/2 trial @MolTherapy cell.com/molecular-ther… 🇨🇳

🔵 Bravoo, Carlos Romeu, allá donde estés! 🕊️ - Por esta viñeta, en 2009, Carlos Romeu, uno de los fundadores de la revista El Jueves, fue expulsado de El País por las presiones de la embajada de Israel. Era la primera vez que criticaba al gobierno Israelí.

Can blood proteins predict lupus before diagnosis? New study using @UK_Biobank data says yes. Machine learning models trained on serum proteomics identified lupus with ~90% sensitivity, outperformed polygenic risk scores, and flagged novel biomarkers. Replicated in independent cohorts from Sweden and China. A&R doi.org/10.1002/art.70…

#Gout is increasingly recognized as an #autoinflammatory disease driven by #NLRP3 #inflammasome activation, rather than solely a metabolic disorder of elevated serum #urate (SU). Traditional treatments like NSAIDs, glucocorticoids, and colchicine are non-specific, while direct IL-1β inhibitors (e.g., canakinumab and anakinra) offer more targeted options for acute flares, particularly in patients with contraindications or poor response to standard therapies. Canakinumab has shown superior efficacy over anakinra, likely due to differences in mechanism and half-life. Emerging therapies focus on NLRP3 inflammasome inhibition, including small-molecule inhibitors like dapansutrile and natural compounds (procyanidin B2, cherry anthocyanins). Notably, existing drugs such as probenecid, allopurinol, and colchicine also exhibit anti-NLRP3 effects through various mechanisms (e.g., microtubule disruption by colchicine). This shift toward viewing gout as a sterile autoinflammatory condition triggered by monosodium urate (MSU) crystals as DAMPs opens new avenues for precision treatments beyond urate-lowering therapy alone. *From: Schlesinger N, Kaufmann D. Is gout an autoinflammatory disease? Curr Rheumatol Rep. 2026;28(1):9. 🔗doi.org/10.1007/s11926…

Idiopathic inflammatory #myopathies (IIM) are associated with significantly increased adverse #pregnancy outcomes, as demonstrated by a systematic review and meta-analysis that included five population-based retrospective cohort studies: Key findings (compared to non-IIM women): ◦ Hypertensive disorders of pregnancy: OR 2.73 (95% CI 1.76–4.23, p < 0.00001) ◦ Cesarean section: OR 2.03 (95% CI 1.37–3.00, p = 0.004) ◦ Preterm birth: OR 3.71 (95% CI 2.35–5.85, p < 0.00001 ◦ Small for gestational age / Intrauterine growth restriction (SGA/IUGR): OR 1.90 (95% CI 1.03–3.51, p = 0.04) This study highlights that IIM in pregnancy is associated with higher rates of hypertensive disorders, cesarean delivery, preterm birth, and growth-restricted infants. Residual confounding by disease activity and treatment is possible. *Yang Y, Meng D, Huo R, Huang Y, Huang X, Lin J. Adverse pregnancy outcomes in adult patients with idiopathic inflammatory myopathy: a systematic review and meta-analysis. Arthritis Care Res. Accepted manuscript. Published online March 23, 2026. 🔗doi.org/10.1002/acr.80…

La procesión de nuestra señora de Quirón Esperando el paso de la Santísima línea 10

A renaissance in targeting the PI3K/AKT/mTOR pathway nature.com/articles/s4157… rdcu.be/faYxr This new Perspective discusses how advances in understanding of PI3K signalling in disease and novel pharmacological strategies are revitalizing interest in targeting the pathway

Israel is a modern-day Nazi state. Zionism is definitely Nazism. Above, the film of The Pianist, which recreates the segregation of Jews in the Nazi ghetto of Warsaw, where they were forbidden to pass through the streets, 1943. Below, the zionist ghetto in the West Bank, where Palestinians are segregated and forbidden to pass through the streets, 2025.

El país de la pena de muerte a menores, los vuelos de la CIA, Guantánamo, el ICE y su política de separar a los hijos de sus madres o las torturas en la cárcel de Abu Ghraib, cree que España no respetó los derechos de Noelia…

Soldado israelí le dice al joven palestino que siga su camino, luego practican tiro a distancia y lo asesinan. Israel no es un estado sino una organización terrorista.

POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein and Skin changes) syndrome is a rare multisystem disorder where early identification is essential for better long term outcomes. Yet it is often misdiagnosed. Gonçalves et al review the condition here: jnnp.bmj.com/content/early/… And this is a related editorial: jnnp.bmj.com/content/early/…

Cómo explicar la España actual a un extraterrestre…

Online now: Acute and chronic infections drive distinct trajectories in human memory CD4+ T cell formation dlvr.it/TRqNyb