Ankit Kalucha

@brunolarvol @drenriquegrande @apolo_andrea Uncertain. No pc reaction.

@drenriquegrande @apolo_andrea @Ankitowledge : what rating did we add to CLIN ?

⚡️ Final THOR-2 readout: oral erdafitinib improved RFS vs intravesical chemo in FGFR3/2-altered high-risk papillary NMIBC and showed durable CRs in CIS and intermediate-risk cohorts. Safety in line with FGFR inhibitors. Despite early stop/small N, it reinforces FGFR-targeted strategies in NMIBC and supports intravesical TAR-210. #BladderCancer sciencedirect.com/science/articl…

NEW ASCO Guidelines Assistant tool leverages Google Cloud Vertex AI platform & Gemini models, enabling oncology clinicians to quickly access evidence-based clinical guidelines.

@brunolarvol US and china = RoW

Does it mean ~100k oncologists globally ? That’s the number I used informally. @Ankitowledge

Immune cell effector-associated neurotoxicity syndrome (ICANS) is a less well understood entity related to cytokine disruption of BBB and comprising diverse neurological symptoms. ICANS was rare (<10%) and no ICANS 3 or more was observed. (pic from Sands Cancer 2024) 🧵12/15

Do ΔORR and ΔDoR Predict PFS and OS Hazard Ratios Across Cancer RCTs? #CancerTrials #RCTs #MedicalAI

@brunolarvol This is at publication level and not registry

@Erman_Akkus @QuantumOnc @Ankitowledge : any implications for CLIN ?

CONSORT 2025 statement: updated guideline for reporting randomized trials | Nature Medicine nature.com/articles/s4159…

@nunthewizer53 Sure. Can help.

@Ankitowledge I want to present the benefits of AI for cancer research to a support, lobby group and ultimately to researchers, trainee patient advocate. Have you a synopsis?

@brunolarvol @JoachimSchork @Jud_Prz @MedinDarko Distinct roles @brunolarvol PCA is for identifying correlation between important features from a given set

@JoachimSchork @Ankitowledge @Jud_Prz @MedinDarko : is PCA old school (vs embedding) ? Or both have clear and distinct roles ? (Thanks @JoachimSchork for the post).

Principal Component Analysis (PCA) is a powerful tool for dimensionality reduction, used to simplify complex data sets while retaining their most important features. It transforms the original variables into a new set of uncorrelated variables called principal components. These components capture the maximum variance in the data, making it easier to analyze and visualize. Key Points: ✔️ Simplifies data sets by reducing the number of variables. ✔️ Helps in identifying patterns and insights. ✔️ Improves the performance of machine learning models. ❌ May result in loss of some information. ❌ Interpretation of components can be challenging. Practical Implementation: 🔹 R: Use prcomp() from the stats package for performing PCA. 🔹 Python: Use PCA from the sklearn.decomposition module for PCA implementation. For a detailed step-by-step tutorial on PCA, including practical examples, check out my tutorials created in collaboration with Paula Villasante Soriano & @Cansu_SG. Article: statisticsglobe.com/principal-comp… Video: youtube.com/watch?v=DngS4L… Furthermore, I have created an extensive introduction to PCA, which explains the theoretical concepts of PCA as well as how to apply it in R programming. More info: statisticsglobe.com/online-course-… #database #DataScience #DataAnalytics #Rpackage #RStats #R #StatisticalAnalysis

@drmpk91 @NatRevClinOncol @brunolarvol

Immunotherapy for advanced-stage squamous cell lung cancer nature.com/articles/s4157… @NatRevClinOncol #LCSM

@brunolarvol @DrYukselUrun @ASCO @JCOCCI_ASCO @APCCC_Lugano @AarmstrongDuke @neerajaiims @yekeduz_emre @DrRanaMcKay @PBarataMD @TiansterZhang @PGrivasMDPhD @Silke_Gillessen @nataliagandur @OncBrothers @TwoOncDocs AI gen.... agree?

@Ankitowledge @DrYukselUrun @ASCO @JCOCCI_ASCO @APCCC_Lugano @AarmstrongDuke @neerajaiims @yekeduz_emre @DrRanaMcKay @PBarataMD @TiansterZhang @PGrivasMDPhD @Silke_Gillessen @nataliagandur @OncBrothers @TwoOncDocs Let’s post our sentiment analysis ?

KEYNOTE-921 Final Analysis: Adding pembrolizumab to docetaxel in mCRPC did not significantly improve rPFS. @ASCO @JCOCCI_ASCO @APCCC_Lugano @AarmstrongDuke ascopubs.org/doi/pdf/10.120…

Deep research cost evaluation of the recent Stage IV NSCLC With Driver Alterations: ASCO Living Guideline v2024.3 #nsclc #ASCO #lungcancer #Oncology

#checkmate274 Deep Research

SWOT by Deep Research. Potential SOC SERENA 6.

Generative Reward Models Self-Taught Reasoning (STAR) in AI Training for cancer clinical trials

Mixture-of-experts Concepts

@ArndtVogel @TheLancetOncol @myESMO @brunolarvol

Comparison of 1st chemotherapy in unresectable locally advanced or metastatic #PDAC @TheLancetOncol doi.org/10.1016/S1470-… 🔎systematic review & Bayesian network meta-analysis, 79 trials, 22 168 pts 👉NALIRIFOX & FOLFIRINOX may be the preferred options if feasible @myESMO

@brunolarvol @ArndtVogel @ilca @myESMO @EASLedu @brunolarvol positive or Mixed?

@ArndtVogel @ilca @myESMO @EASLedu @Ankitowledge OS immature

LEAP-012: A Phase 3 Study of Lenvatinib Plus Pembrolizumab Plus Transarterial Chemoembolization for Intermediate-Stage HCC @ILCA 👉meaningful improvement in ORR & PFS 👉OS immature 🧐TACE + ICI based💊is a great option for downsizing & disease control in HCC @myESMO @EASLedu

@mjuanfi81 @brunolarvol prac...

PSA screening guidelines. Start age?Stop age?Frequency? Debate is served. doi:10.1001/jamaoncol.2024.3909