Antebi Lab

🚨Publication @Micropub7n micropublication.org/journals/biolo… PoC study by @ypark_bioinfo: deconvolving the C. elegans proteome to organ- & tissue-level ageing trajectories expands the use of single-worm proteomics data as a powerful tool to study dynamic cellular changes during ageing.

Today we said farewell to our PhD student turned postdoc @BallhysaEugene. The energy in his conversations matched his enthusiasm for science🔬🐟We’ll miss you—and we wish you all the best for the road ahead!

🥳🎓Congratulations to Maja on an outstanding master’s thesis defense. Your rigor, perseverance, and dedication are exemplary. Excited to see what comes next.🌟#GradLife #MastersDefense

4/4 Perturbing either the mitochondrial ribosome or the RNase P/MRP complex restores ribosomal balance & extends lifespan, suggesting that improving ribosome coordination, rather than reducing overall biogenesis, is a promising avenue to support cellular health in ageing.

3/4 Using C. elegans, we find that loss of the nucleolar regulator, ncl-1/TRIM2-3, disrupts ribosomal balance, leading to proteostasis defects and premature aging. Ribosomal biogenesis becomes uncoordinated, causing imbalanced ribosomal components and translational dysfunction.

1/4 Our preprint by @VMartinezMigu3l & Till Popkes van Oepen “Modulation of the RNase P/MRP complex and mitochondrial ribosome enhances cytosolic ribosome coordination and sustains longevity” is now live @biorxivpreprint 📄#agingbiology #ribosome 👉biorxiv.org/content/10.648…

Our tiny market of longevity dreams—lab merch, publications, Flammkillifish and ‘rejuvenation’ tonics—won🥈in the annual window decoration contest!🥇to the Huppertz and Scheiblich labs chasing the Grinch for their data. Backups, people! 💾 #LabLife #AgingResearch #FestiveScience

From worms to humans, our lab gathered for the annual festive brunch and Secret Santa—because community is the best longevity intervention🎁🎄🫶 #LabLife #Longevity #ScienceCommunity

🚨New @biorxivpreprint: We model the splicing disease Verheij syndrome using C. elegans. Disruption of methionine and phospholipid metabolism drives growth defects; vitamin #B12 restores the balance and rescues development! #metabolism #RNAsplicing doi.org/10.1101/2025.0…

@BallhysaEugene, @VMartinezMigu3l & @shamstabrez87 are just back from Copenhagen🇩🇰#ARDD2025! @kkawamura148991 took the stage to share his insights on fasting-refeeding and age-restoration. ⌛️🍽️ Turns out, the fountain of youth might just be a histone away!🪱🔬 #Rejuvenation

Our lab's BBQ last Friday was a blast! Meticulous research revealed the ultimate anti-aging formula: juicy burgers and great company! 🍔👩‍🔬 #AgingResearch

🏆⚽️ A huge shoutout to the Antebi lab's team 'C(riminally) elegant' for winning the human Foosball match at the CECAD Summer Party @CECAD_! Your elegance on the field is unmatched!💪 #LabLegends #Foosball

7/7 In sum, hlh-30 mutation causes misalignment of nutrient cues and growth signaling, resulting in DNA damage & cellular senescence, which abrogates stem cell and organismal longevity.Cellular senescence is an evolutionarily ancient response to damage conserved even in C.elegans

6/7 Together with Manuel Serrano’s group, we found that TFEB loss reduces survivorship in both embryonic and cancer diapause, and that TFEB and TGFβ signaling are regulated during diapause. Hence, targeting TFEB might undermine cancer dormancy and prevent relapse in vivo.

1/7 Out now @NatureAging🚨 We identified a genetic network of TFEB, TGFβ and NOTCH signaling regulating stem cell resilience, rejuvenation & senescence in C.elegans in response to nutrient cues, with conservation across taxa. @TJNonninger, J.Mak &B.Gerisch nature.com/articles/s4358…